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Literature summary for 2.3.1.5 extracted from

  • Weber, W.W.
    N-Acetyltransferase (mammalian liver) (1971), Methods Enzymol., 17B, 805-811.
No PubMed abstract available

Inhibitors

Inhibitors Comment Organism Structure
Cu2+
-
Oryctolagus cuniculus
Cu2+
-
Rattus norvegicus
Mn2+
-
Oryctolagus cuniculus
additional information
-
Homo sapiens
additional information no inhibition by CdCl2, arsenite, diisopropylfluorophosphate Oryctolagus cuniculus
additional information
-
Platyrrhini
additional information
-
Rattus norvegicus
N-ethylmaleimide
-
Homo sapiens
N-ethylmaleimide
-
Oryctolagus cuniculus
N-ethylmaleimide
-
Platyrrhini
N-ethylmaleimide
-
Rattus norvegicus
Ni2+
-
Oryctolagus cuniculus
p-chloromercuribenzoate
-
Oryctolagus cuniculus
Zn2+
-
Oryctolagus cuniculus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.02
-
acetyl-CoA
-
Oryctolagus cuniculus
0.18
-
isoniazid
-
Oryctolagus cuniculus

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Oryctolagus cuniculus
-
new Zealand white
-
Platyrrhini
-
-
-
Rattus norvegicus
-
-
-

Reaction

Reaction Comment Organism Reaction ID
acetyl-CoA + an arylamine = CoA + an N-acetylarylamine ping-pong bi-bi mechanism Homo sapiens
acetyl-CoA + an arylamine = CoA + an N-acetylarylamine ping-pong bi-bi mechanism Rattus norvegicus
acetyl-CoA + an arylamine = CoA + an N-acetylarylamine ping-pong bi-bi mechanism Oryctolagus cuniculus
acetyl-CoA + an arylamine = CoA + an N-acetylarylamine ping-pong bi-bi mechanism Platyrrhini

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Homo sapiens
-
liver
-
Rattus norvegicus
-
liver
-
Oryctolagus cuniculus
-
liver
-
Platyrrhini
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.16
-
-
Oryctolagus cuniculus

Storage Stability

Storage Stability Organism
4°C, 20% loss of activity within 4 days in the presence of 1 mM EDTA Oryctolagus cuniculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-CoA + 4-aminobenzoic acid
-
Homo sapiens CoA + 4-acetylaminobenzoic acid
-
?
acetyl-CoA + 4-aminobenzoic acid
-
Rattus norvegicus CoA + 4-acetylaminobenzoic acid
-
?
acetyl-CoA + 4-aminobenzoic acid
-
Oryctolagus cuniculus CoA + 4-acetylaminobenzoic acid
-
?
acetyl-CoA + 4-aminosalicylic acid
-
Homo sapiens CoA + 4-acetylamino-2-hydroxybenzoate
-
?
acetyl-CoA + 4-aminosalicylic acid
-
Oryctolagus cuniculus CoA + 4-acetylamino-2-hydroxybenzoate
-
?
acetyl-CoA + aniline
-
Oryctolagus cuniculus CoA + acetanilide
-
?
acetyl-CoA + diaminodiphenylsulfone
-
Oryctolagus cuniculus CoA + ?
-
?
acetyl-CoA + histamine
-
Rattus norvegicus CoA + N-acetylhistamine
-
?
acetyl-CoA + histamine
-
Oryctolagus cuniculus CoA + N-acetylhistamine
-
?
acetyl-CoA + hydralazine
-
Oryctolagus cuniculus CoA + ?
-
?
acetyl-CoA + isoniazide
-
Homo sapiens CoA + acetylniazide
-
?
acetyl-CoA + isoniazide i.e. isonicotinyl hydrazide Oryctolagus cuniculus CoA + acetylniazide
-
?
acetyl-CoA + p-phenetidine
-
Oryctolagus cuniculus CoA + N-(4-ethoxyphenyl)-acetamide
-
?
acetyl-CoA + serotonin
-
Rattus norvegicus CoA + N-acetylserotonin
-
?
acetyl-CoA + serotonin
-
Oryctolagus cuniculus CoA + N-acetylserotonin
-
?
acetyl-CoA + sulfadiazine
-
Homo sapiens CoA + ?
-
?
acetyl-CoA + sulfadiazine
-
Oryctolagus cuniculus CoA + ?
-
?
acetyl-CoA + sulfamerazine
-
Homo sapiens CoA + ?
-
?
acetyl-CoA + sulfamerazine
-
Oryctolagus cuniculus CoA + ?
-
?
acetyl-CoA + sulfamethazine
-
Homo sapiens CoA + N-4-acetylsulfamethazine
-
?
acetyl-CoA + sulfamethazine
-
Rattus norvegicus CoA + N-4-acetylsulfamethazine
-
?
acetyl-CoA + sulfamethazine
-
Oryctolagus cuniculus CoA + N-4-acetylsulfamethazine
-
?
acetyl-CoA + sulfanilamide
-
Oryctolagus cuniculus CoA + ?
-
?
additional information
-
Homo sapiens ?
-
?
additional information
-
Rattus norvegicus ?
-
?
additional information
-
Platyrrhini ?
-
?
additional information N-diacetyl cysteamine can replace acetyl-CoA with less than 10% efficiency Oryctolagus cuniculus ?
-
?
additional information no substrate: phenylalanine, cyclohexylamine Oryctolagus cuniculus ?
-
?
additional information acetylthiocholine can replace acetyl-CoA Oryctolagus cuniculus ?
-
?

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
55
-
inactivation after 2 min Oryctolagus cuniculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
5 9
-
Oryctolagus cuniculus
5.7
-
-
Rattus norvegicus
5.7
-
-
Oryctolagus cuniculus
5.7
-
-
Platyrrhini
5.7 7.4 sulfamethazine Oryctolagus cuniculus

pH Stability

pH Stability pH Stability Maximum Comment Organism
6.5
-
irreversible inactivation below Oryctolagus cuniculus