Literature summary for 2.3.1.48 extracted from

Lopes da Rosa, J.; Boyartchuk, V.L.; Zhu, L.J.; Kaufman, P.D.
Histone acetyltransferase Rtt109 is required for Candida albicans pathogenesis (2010), Proc. Natl. Acad. Sci. USA, 107, 1594-1599.

Search for more literature for 2.3.1.48

Application

Application	Comment	Organism
drug development	the enzyme is a unique target for therapeutic antifungal compounds	Candida albicans

Protein Variants

Protein Variants	Comment	Organism
additional information	deletion of Rtt109 in the clinical isolate SC5314. rtt109-/- mutant cells lack acetylated H3K56 and are hypersensitive to genotoxic agents. Additionally, rtt109-/- mutant cells constitutively display increased H2A S129 phosphorylation and elevated DNA repair gene expression, consistent with endogenous DNA damage. Importantly, rtt109-/- mutant cells are significantly less pathogenic in BALB/cByJ mice and more susceptible to killing by macrophages in vitro than are wild-type cells, phenotype, overview. rtt109-/- mutant cells display an altered profile of metabolic gene expression compared to the wild-type and constitutively induce DNA repair genes, transcription profile, overview	Candida albicans

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
acetyl-CoA + histone H3	Candida albicans	acetylation of Lys56	CoA + acetylhistone H3	-	?

Organism

Organism	UniProt	Comment	Textmining
Candida albicans	-	clinical isolate SC5314, ORF19.7491	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
acetyl-CoA + histone H3	acetylation of Lys56	Candida albicans	CoA + acetylhistone H3	-	?

Synonyms

Synonyms	Comment	Organism
Rtt109	fungal-specific histone acetyltransferase	Candida albicans

Cofactor

Cofactor	Comment	Organism	Structure
acetyl-CoA	-	Candida albicans

General Information

General Information	Comment	Organism
physiological function	Rtt109 is important for yeast model organisms to survive DNA damage and maintain genome integrity, and Rtt109 is particularly important for fungal pathogenicity	Candida albicans

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Release 2023.1 (January 2023)