Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | partial loop deletion or autoacetylation of up to 17 sites in p300 HAT leads to an increase in catalytic activity by 4-10fold | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
Y1467F | the mutant shows a 150fold reduction in catalytic activity relative to wild-type enzyme | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + histone H4 | activity with synthetic histone H4 tail peptide substrate of p300 that shows different degrees of autoacetylation, overview. Tyr1467 appears to serve as a general acid protonating the departing coenzyme A sulfur | Homo sapiens | CoA + acetylhistone H4 | - |
? | |
additional information | p300 performs autoacetylation, overview | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
p300 | - |
Homo sapiens |
p300 HAT | - |
Homo sapiens |
p300/CBP histone acetyltransferase | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
acetyl-CoA | - |
Homo sapiens |