Protein Variants | Comment | Organism |
---|---|---|
additional information | isolation of a temperature-sensitive allele of the essential mst gene. Mutant mst1 cells show a pleiotropic phenotype at the restrictive temperature. They are sensitive to a variety of DNA-damaging agents and to the spindle poison thiabendazole. Mutant mst1 has an increased frequency of Rad22 repair foci, suggesting endogenous damage, overview | Schizosaccharomyces pombe |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Schizosaccharomyces pombe | Mst1 interacts with a number of proteins involved in chromosome integrity and centromere function, including the methyltransferase Skb1, the recombination mediator Rad22, Sc Rad52, the chromatin assembly factor Hip1, Sc Hir1, and the Msc1 protein related to a family of histone demethylases, detailed interaction analysis, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Schizosaccharomyces pombe | - |
diverse strains, overview | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Mst1 interacts with a number of proteins involved in chromosome integrity and centromere function, including the methyltransferase Skb1, the recombination mediator Rad22, Sc Rad52, the chromatin assembly factor Hip1, Sc Hir1, and the Msc1 protein related to a family of histone demethylases, detailed interaction analysis, overview | Schizosaccharomyces pombe | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
KAT5 | - |
Schizosaccharomyces pombe |
More | Mst1 is a member of the MYST family of histone acetyltransferases and is the likely orthologue of Saccharomyces cerevisiae Esa1 and human Tip60, i.e. KAT5 | Schizosaccharomyces pombe |
Mst1 | - |
Schizosaccharomyces pombe |
General Information | Comment | Organism |
---|---|---|
physiological function | Mst1 is essentially required for damage response and chromosome segregation, it plays essential roles in maintenance of genome stability and recovery from DNA damage | Schizosaccharomyces pombe |