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Literature summary for 2.3.1.48 extracted from
- HBO1 histone acetylase is a coactivator of the replication licensing factor Cdt1 (2008), Genes Dev., 22, 2633-2638.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| CDT1 | licensing factor Cdt1 stabilizes HBO1 at origins. HBO1 directly interacts with Cdt1, and it enhances Cdt1-dependent rereplication | Homo sapiens | |
| additional information | HBO1 interacts both with transcriptional activator proteins and with MCM2 and ORC1 | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| additional information | HBO1 dissociation from origins is either triggered by proteolytic degradation of a key licensing cofactor or by post-translational event(s) induced by HU and/or actinomycin D treatment(s) | Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| nucleus | HBO1 is targeted to origins through a direct interaction with the licensing regulator Cdt1 | Homo sapiens | 5634 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Homo sapiens | HBO1 histone acetylase is involved in DNA replication licensing and associates with replication origins, located within the HPRT1 coding sequence, specifically during the G1 phase of the cell cycle in a manner that depends on the replication licensing factor Cdt1, but is independent of the Cdt1 repressor geminin | ? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| cell culture | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acetyl-CoA + histone H3 | - |
Homo sapiens | CoA + acetylhistone H3 | - |
? | |
| additional information | HBO1 histone acetylase is involved in DNA replication licensing and associates with replication origins, located within the HPRT1 coding sequence, specifically during the G1 phase of the cell cycle in a manner that depends on the replication licensing factor Cdt1, but is independent of the Cdt1 repressor geminin | Homo sapiens | ? | - |
? | |
| additional information | HBO1 interacts both with transcriptional activator proteins and with MCM2 and ORC1 | Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| HBO1 | - |
Homo sapiens |
| histone acetylase | - |
Homo sapiens |
| human acetylase binding to ORC1 | - |
Homo sapiens |
| More | HBO1 is a MYST family histone acetylase | Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| acetyl-CoA | - |
Homo sapiens | |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | HBO1 depletion reduces the rate of DNA synthesis, the amount of MCM complex bound to chromatin, and progression through S phase | Homo sapiens |
| physiological function | HBO1 histone acetylase is important for DNA replication licensing in a Cdt1-dependent manner, overview. HBO1 plays a direct role at replication origins as a coactivator of the Cdt1 licensing factor. As HBO1 is also a transcriptional coactivator, it has the potential to integrate internal and external stimuli to coordinate transcriptional responses with initiation of DNA replication. HBO1 is not required for Cdt1 association with replication origins | Homo sapiens |
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