Protein Variants | Comment | Organism |
---|---|---|
additional information | overexpression of the dominant-negative, catalytically inactive mutant Hbo1 causes reduced histone H4 acetylation in both HeLa and MCF-7 cells | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
nucleosome | - |
Homo sapiens | 786 | - |
nucleus | - |
Homo sapiens | 5634 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + histone H4 | Homo sapiens | HBO1 regulates global histone H4 acetylation | CoA + acetylhistone H4 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
A-549 cell | - |
Homo sapiens | - |
breast cancer cell | - |
Homo sapiens | - |
fibroblast | - |
Homo sapiens | - |
gastric cancer cell | - |
Homo sapiens | - |
HFF2/T cell | - |
Homo sapiens | - |
MCF-7 cell | - |
Homo sapiens | - |
additional information | semiquantitative determination of enzyme in primary cancers of different tissues, overview. Hbo1 is approximately equimolar with the number of active replication origins in normal human fibroblasts but is an order of magnitude more abundant in both MCF7 and Saos-2 established cancer cell lines. Strong Hbo1 protein expression in carcinomas of the testis, ovary, breast, stomach/esophagus, and bladder | Homo sapiens | - |
ovary cancer cell | - |
Homo sapiens | - |
SAOS-2 cell | - |
Homo sapiens | - |
testicular cancer cell | - |
Homo sapiens | - |
urinary bladder cancer cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + histone H4 | HBO1 regulates global histone H4 acetylation | Homo sapiens | CoA + acetylhistone H4 | - |
? | |
acetyl-CoA + histone H4 | recombinant Hbo1 can acetylate nucleosomal histone H4 in vitro, with a preference for Lys5 and Lys12, mapping of acetylation sites, overview | Homo sapiens | CoA + acetylhistone H4 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
HAT | - |
Homo sapiens |
HBO1 | - |
Homo sapiens |
histone H4 acetyltransferase | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
acetyl-CoA | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | Hbo1 plays a role as chromatin factor serving as a positive regulator of DNA replication , chromatin structure plays an important role in DNA replication initiation | Homo sapiens |