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Literature summary for 2.3.1.48 extracted from

  • Sung, B.; Pandey, M.K.; Ahn, K.S.; Yi, T.; Chaturvedi, M.M.; Liu, M.; Aggarwal, B.B.
    Anacardic acid (6-nonadecyl salicylic acid), an inhibitor of histone acetyltransferase, suppresses expression of nuclear factor-kappaB-regulated gene products involved in cell survival, proliferation, invasion, and inflammation through inhibition of the i (2008), Blood, 111, 4880-4891.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
TNF-alpha
-
Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information down-regulation of the p300 HAT gene by RNAi abrogates the effect of anarcardic acid on TNF-induced NF-kappaB activation. This result shows that p300 HAT is a target of anarcardic acid for supression of NF-kappaB activation Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
anacardic acid anarcardic acid supresses TNF-induced HAT activity Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
KBM-5 cell
-
Homo sapiens
-
kidney cell line human embryonic kidney A293 cells Homo sapiens
-

Synonyms

Synonyms Comment Organism
histone acetyltransferase
-
Homo sapiens
p300 HAT
-
Homo sapiens