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Literature summary for 2.3.1.48 extracted from
- Studies on histone acetyltransferase. Partial purification and basic properties (1982), J. Biol. Chem., 257, 12893-12900.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| dithiothreitol | 10 mM: stimulation, 100 mM: inhibition | Rattus norvegicus |  |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | Mg2+ or Ca2+ required at low concentration of 5 mM, inhibition at 10-20 mM | Rattus norvegicus | |
| Co2+ | - |
Rattus norvegicus | |
| dithiothreitol | 10 mM: stimulation, 100 mM: inhibition | Rattus norvegicus | |
| Fe2+ | - |
Rattus norvegicus | |
| Hg2+ | - |
Rattus norvegicus | |
| Mg2+ | Mg2+ or Ca2+ required at low concentration, 5 mM, inhibition at 10-20 mM | Rattus norvegicus | |
| Mn2+ | - |
Rattus norvegicus | |
| N-ethylmaleimide | - |
Rattus norvegicus | |
| Ni2+ | - |
Rattus norvegicus | |
| Zn2+ | - |
Rattus norvegicus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| nucleus | - |
Rattus norvegicus | 5634 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | Ca2+ required at low concentration (5 mM), inhibition at 10-20 mM | Rattus norvegicus | |
| Mg2+ | Mg2+ required at low concentration (5 mM), inhibition at 10-20 mM | Rattus norvegicus | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 96000 | - |
gel filtration | Rattus norvegicus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acetyl-CoA + histone | - |
Rattus norvegicus | CoA + acetylhistone | - |
? | |
| acetyl-CoA + histone H3 | histone H3: preferred substrate | Rattus norvegicus | CoA + acetylhistone H3 | - |
? | |
Temperature Stability [°C]
| Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
half-life: 22.2 min | Rattus norvegicus |
| 37 | - |
glycerol protects against thermal denaturation at 37°C | Rattus norvegicus |
| 45 | - |
half-life: 9.54 min | Rattus norvegicus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| additional information | - |
pI: 7.8-8.2 | Rattus norvegicus |
| 7.5 | - |
- |
Rattus norvegicus |
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Release 2023.1 (January 2023)
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