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Literature summary for 2.3.1.48 extracted from

  • Libby, P.R.
    Rat liver nuclear N-acetyltransferases: separation of two enzymes with both histone and spermidine acetyltransferase activity (1980), Arch. Biochem. Biophys., 203, 384-389.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
DNA in vitro, enzyme form A inhibited, enzyme form B relatively insensitive Rattus norvegicus
EDTA high concentrations Rattus norvegicus
histone inhibits spermidine acetylation, enzyme forms A and B Rattus norvegicus
spermidine inhibits histone acetylation at high concentrations, enzyme forms A and B Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.01
-
acetyl-CoA + spermidine, enzyme form B Rattus norvegicus
0.015
-
acetyl-CoA + spermidine, enzyme form A Rattus norvegicus
0.18
-
spermidine enzyme form B Rattus norvegicus
0.27
-
spermidine enzyme form A Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus enzyme form A and B Rattus norvegicus 5634
-

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
2 enzyme forms: A and B
-

Purification (Commentary)

Purification (Comment) Organism
partial, enzyme forms A and B Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.00186
-
enzyme form B Rattus norvegicus
0.00196
-
enzyme form A Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-CoA + 1,4-butanediamine enzyme form A and B, low activity Rattus norvegicus ?
-
?
acetyl-CoA + 1,4-butanediamine i.e. putrescine Rattus norvegicus ?
-
?
acetyl-CoA + 1,5-pentanediamine enzyme form A and B, low activity Rattus norvegicus ?
-
?
acetyl-CoA + 1,5-pentanediamine i.e. cadaverine Rattus norvegicus ?
-
?
acetyl-CoA + 1,6-hexanediamine enzyme form A shows low activity , B not Rattus norvegicus ?
-
?
acetyl-CoA + histone histone H1 poor substrate Rattus norvegicus CoA + acetylhistone
-
?
acetyl-CoA + histone H1 histone H1 poor substrate Rattus norvegicus CoA + acetylhistone H1
-
?
acetyl-CoA + histone H3 histone H3: preferred substrate Rattus norvegicus CoA + acetylhistone H3
-
?
acetyl-CoA + histone H4 histone H4 is a poor substrate Rattus norvegicus CoA + acetylhistone H4
-
?
acetyl-CoA + spermidine
-
Rattus norvegicus ?
-
?
acetyl-CoA + spermine
-
Rattus norvegicus ?
-
?
additional information diaminodipropylamine and 1,3-propanediamine are no substrates Rattus norvegicus ?
-
?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.8
-
enzyme form B, substrate histone Rattus norvegicus
7.8 8.8 enzyme form B, substrate spermidine Rattus norvegicus
8.5 8.8 enzyme form A, substrate spermidine Rattus norvegicus
8.8
-
enzyme form A, substrate histine Rattus norvegicus