BRENDA - Enzyme Database show
show all sequences of 2.3.1.47

Detection and characterization of a thermophilic biotin biosynthetic enzyme, 7-keto-8-aminopelargonic acid synthase, from various thermophiles

Kubota, T.; Izumi, Y.; Biosci. Biotechnol. Biochem. 76, 685-690 (2012)

Data extracted from this reference:

Cloned(Commentary)
Commentary
Organism
GST-fusion protein expressed in Escherichia coli JM109
Aquifex aeolicus
GST-fusion protein expressed in Escherichia coli JM109
Escherichia coli
GST-fusion protein expressed in Escherichia coli JM109
Geobacillus kaustophilus
GST-fusion protein expressed in Escherichia coli JM109
Hungateiclostridium thermocellum
GST-fusion protein expressed in Escherichia coli JM109
Symbiobacterium thermophilum
His-tagged protein expressed in Escherichia coli Rosetta-gami (DE3)
Thermosynechococcus elongatus
KM Value [mM]
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.01
-
pimeloyl-CoA
pH 6.0, 60°C
Aquifex aeolicus
0.02
-
pimeloyl-CoA
pH 6.0, 60°C
Geobacillus kaustophilus
0.025
-
pimeloyl-CoA
pH not specified in the publication, temperature not specified in the publication
Escherichia coli
0.03
-
pimeloyl-CoA
pH 6.0, 60°C
Symbiobacterium thermophilum
0.09
-
L-alanine
pH 6.0, 60°C
Geobacillus kaustophilus
0.23
-
L-alanine
pH 6.0, 60°C
Aquifex aeolicus
0.5
-
L-alanine
pH not specified in the publication, temperature not specified in the publication
Escherichia coli
2.28
-
L-alanine
pH 6.0, 60°C
Symbiobacterium thermophilum
Molecular Weight [Da]
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
44000
-
x * 44000, SDS-PAGE
Escherichia coli
44000
-
x * 44000, SDS-PAGE
Geobacillus kaustophilus
45000
-
x * 45000, SDS-PAGE
Aquifex aeolicus
45000
-
x * 45000, SDS-PAGE
Hungateiclostridium thermocellum
45000
-
x * 45000, SDS-PAGE
Thermosynechococcus elongatus
46000
-
x * 46000, SDS-PAGE
Symbiobacterium thermophilum
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Aquifex aeolicus
-
-
-
Escherichia coli
-
-
-
Geobacillus kaustophilus
-
-
-
Geobacillus kaustophilus JCM 12893
-
-
-
Hungateiclostridium thermocellum
-
-
-
Hungateiclostridium thermocellum ATCC 27405
-
-
-
Symbiobacterium thermophilum
-
-
-
Symbiobacterium thermophilum IAM14863
-
-
-
Thermosynechococcus elongatus
-
-
-
Purification (Commentary)
Commentary
Organism
Glutathione Sepharose chromatography, GST-tag cleavage, Glutathione Sepharose chromatography
Hungateiclostridium thermocellum
Glutathione Sepharose chromatography, GST-tag cleavage, Glutathione Sepharose chromatography, gel filtration
Aquifex aeolicus
Glutathione Sepharose chromatography, GST-tag cleavage, Glutathione Sepharose chromatography, heat treatment with centrifugation
Symbiobacterium thermophilum
Glutathione Sepharose chromatography, GST-tag cleavage, Glutathione Sepharose chromatography, ion exchange chromatography
Escherichia coli
Glutathione Sepharose chromatography, GST-tag cleavage, Glutathione Sepharose chromatography, ion exchange chromatography
Geobacillus kaustophilus
immobilized metal ion affinity chromatography (Ni2+), His-tag cleavage, immobilized metal ion affinity chromatography (Ni2+), gel filtration
Thermosynechococcus elongatus
Specific Activity [micromol/min/mg]
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
0.032
-
glycine, pimeloyl-CoA, pH 6.0, 60°C
Symbiobacterium thermophilum
0.071
-
L-alanine, pimeloyl-CoA, pH 6.0, 60°C
Geobacillus kaustophilus
0.078
-
L-alanine, pimeloyl-CoA, pH 6.0, 60°C
Symbiobacterium thermophilum
0.272
-
L-alanine, acetyl-CoA, pH 6.0, 60°C
Symbiobacterium thermophilum
0.897
-
glycine, acetyl-CoA, pH 6.0, 60°C
Symbiobacterium thermophilum
2.46
-
L-alanine, pimeloyl-CoA, pH 6.0, 60°C
Aquifex aeolicus
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
glycine + acetyl-CoA
-
719127
Symbiobacterium thermophilum
?
-
-
-
?
glycine + acetyl-CoA
-
719127
Symbiobacterium thermophilum IAM14863
?
-
-
-
?
glycine + pimeloyl-CoA
-
719127
Symbiobacterium thermophilum
?
-
-
-
?
glycine + pimeloyl-CoA
-
719127
Symbiobacterium thermophilum IAM14863
?
-
-
-
?
L-alanine + acetyl-CoA
-
719127
Symbiobacterium thermophilum
?
-
-
-
?
L-alanine + acetyl-CoA
-
719127
Symbiobacterium thermophilum IAM14863
?
-
-
-
?
L-alanine + pimeloyl-CoA
-
719127
Escherichia coli
8-amino-7-oxononanoate + CoA + CO2
-
-
-
?
L-alanine + pimeloyl-CoA
-
719127
Hungateiclostridium thermocellum
8-amino-7-oxononanoate + CoA + CO2
-
-
-
?
L-alanine + pimeloyl-CoA
-
719127
Thermosynechococcus elongatus
8-amino-7-oxononanoate + CoA + CO2
-
-
-
?
L-alanine + pimeloyl-CoA
no activity observed with acetyl-CoA, no activity observed with glycine or L-serine
719127
Aquifex aeolicus
8-amino-7-oxononanoate + CoA + CO2
-
-
-
?
L-alanine + pimeloyl-CoA
no activity observed with acetyl-CoA, no activity observed with glycine or L-serine
719127
Geobacillus kaustophilus
8-amino-7-oxononanoate + CoA + CO2
-
-
-
?
L-alanine + pimeloyl-CoA
no activity observed with L-serine
719127
Symbiobacterium thermophilum
8-amino-7-oxononanoate + CoA + CO2
-
-
-
?
L-alanine + pimeloyl-CoA
no activity observed with acetyl-CoA, no activity observed with glycine or L-serine
719127
Geobacillus kaustophilus JCM 12893
8-amino-7-oxononanoate + CoA + CO2
-
-
-
?
L-alanine + pimeloyl-CoA
-
719127
Hungateiclostridium thermocellum ATCC 27405
8-amino-7-oxononanoate + CoA + CO2
-
-
-
?
L-alanine + pimeloyl-CoA
no activity observed with L-serine
719127
Symbiobacterium thermophilum IAM14863
8-amino-7-oxononanoate + CoA + CO2
-
-
-
?
Subunits
Subunits
Commentary
Organism
?
x * 45000, SDS-PAGE
Aquifex aeolicus
?
x * 44000, SDS-PAGE
Escherichia coli
?
x * 44000, SDS-PAGE
Geobacillus kaustophilus
?
x * 45000, SDS-PAGE
Hungateiclostridium thermocellum
?
x * 46000, SDS-PAGE
Symbiobacterium thermophilum
?
x * 45000, SDS-PAGE
Thermosynechococcus elongatus
Temperature Optimum [°C]
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
30
-
-
Escherichia coli
50
60
-
Aquifex aeolicus
50
60
-
Geobacillus kaustophilus
50
60
-
Hungateiclostridium thermocellum
50
60
-
Symbiobacterium thermophilum
50
60
-
Thermosynechococcus elongatus
Temperature Stability [°C]
Temperature Stability Minimum [°C]
Temperature Stability Maximum [°C]
Commentary
Organism
40
-
stable for one h
Escherichia coli
55
-
stable for one h
Symbiobacterium thermophilum
65
-
stable for one h
Thermosynechococcus elongatus
70
-
stable for one h
Hungateiclostridium thermocellum
75
-
stable for one h
Geobacillus kaustophilus
93
-
stable for one h
Aquifex aeolicus
Cofactor
Cofactor
Commentary
Organism
Structure
pyridoxal 5'-phosphate
-
Aquifex aeolicus
pyridoxal 5'-phosphate
-
Escherichia coli
pyridoxal 5'-phosphate
-
Geobacillus kaustophilus
pyridoxal 5'-phosphate
-
Hungateiclostridium thermocellum
pyridoxal 5'-phosphate
-
Symbiobacterium thermophilum
pyridoxal 5'-phosphate
-
Thermosynechococcus elongatus
Cloned(Commentary) (protein specific)
Commentary
Organism
GST-fusion protein expressed in Escherichia coli JM109
Aquifex aeolicus
GST-fusion protein expressed in Escherichia coli JM109
Escherichia coli
GST-fusion protein expressed in Escherichia coli JM109
Geobacillus kaustophilus
GST-fusion protein expressed in Escherichia coli JM109
Hungateiclostridium thermocellum
GST-fusion protein expressed in Escherichia coli JM109
Symbiobacterium thermophilum
His-tagged protein expressed in Escherichia coli Rosetta-gami (DE3)
Thermosynechococcus elongatus
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
pyridoxal 5'-phosphate
-
Aquifex aeolicus
pyridoxal 5'-phosphate
-
Escherichia coli
pyridoxal 5'-phosphate
-
Geobacillus kaustophilus
pyridoxal 5'-phosphate
-
Hungateiclostridium thermocellum
pyridoxal 5'-phosphate
-
Symbiobacterium thermophilum
pyridoxal 5'-phosphate
-
Thermosynechococcus elongatus
KM Value [mM] (protein specific)
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.01
-
pimeloyl-CoA
pH 6.0, 60°C
Aquifex aeolicus
0.02
-
pimeloyl-CoA
pH 6.0, 60°C
Geobacillus kaustophilus
0.025
-
pimeloyl-CoA
pH not specified in the publication, temperature not specified in the publication
Escherichia coli
0.03
-
pimeloyl-CoA
pH 6.0, 60°C
Symbiobacterium thermophilum
0.09
-
L-alanine
pH 6.0, 60°C
Geobacillus kaustophilus
0.23
-
L-alanine
pH 6.0, 60°C
Aquifex aeolicus
0.5
-
L-alanine
pH not specified in the publication, temperature not specified in the publication
Escherichia coli
2.28
-
L-alanine
pH 6.0, 60°C
Symbiobacterium thermophilum
Molecular Weight [Da] (protein specific)
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
44000
-
x * 44000, SDS-PAGE
Escherichia coli
44000
-
x * 44000, SDS-PAGE
Geobacillus kaustophilus
45000
-
x * 45000, SDS-PAGE
Aquifex aeolicus
45000
-
x * 45000, SDS-PAGE
Hungateiclostridium thermocellum
45000
-
x * 45000, SDS-PAGE
Thermosynechococcus elongatus
46000
-
x * 46000, SDS-PAGE
Symbiobacterium thermophilum
Purification (Commentary) (protein specific)
Commentary
Organism
Glutathione Sepharose chromatography, GST-tag cleavage, Glutathione Sepharose chromatography
Hungateiclostridium thermocellum
Glutathione Sepharose chromatography, GST-tag cleavage, Glutathione Sepharose chromatography, gel filtration
Aquifex aeolicus
Glutathione Sepharose chromatography, GST-tag cleavage, Glutathione Sepharose chromatography, heat treatment with centrifugation
Symbiobacterium thermophilum
Glutathione Sepharose chromatography, GST-tag cleavage, Glutathione Sepharose chromatography, ion exchange chromatography
Escherichia coli
Glutathione Sepharose chromatography, GST-tag cleavage, Glutathione Sepharose chromatography, ion exchange chromatography
Geobacillus kaustophilus
immobilized metal ion affinity chromatography (Ni2+), His-tag cleavage, immobilized metal ion affinity chromatography (Ni2+), gel filtration
Thermosynechococcus elongatus
Specific Activity [micromol/min/mg] (protein specific)
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
0.032
-
glycine, pimeloyl-CoA, pH 6.0, 60°C
Symbiobacterium thermophilum
0.071
-
L-alanine, pimeloyl-CoA, pH 6.0, 60°C
Geobacillus kaustophilus
0.078
-
L-alanine, pimeloyl-CoA, pH 6.0, 60°C
Symbiobacterium thermophilum
0.272
-
L-alanine, acetyl-CoA, pH 6.0, 60°C
Symbiobacterium thermophilum
0.897
-
glycine, acetyl-CoA, pH 6.0, 60°C
Symbiobacterium thermophilum
2.46
-
L-alanine, pimeloyl-CoA, pH 6.0, 60°C
Aquifex aeolicus
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
glycine + acetyl-CoA
-
719127
Symbiobacterium thermophilum
?
-
-
-
?
glycine + acetyl-CoA
-
719127
Symbiobacterium thermophilum IAM14863
?
-
-
-
?
glycine + pimeloyl-CoA
-
719127
Symbiobacterium thermophilum
?
-
-
-
?
glycine + pimeloyl-CoA
-
719127
Symbiobacterium thermophilum IAM14863
?
-
-
-
?
L-alanine + acetyl-CoA
-
719127
Symbiobacterium thermophilum
?
-
-
-
?
L-alanine + acetyl-CoA
-
719127
Symbiobacterium thermophilum IAM14863
?
-
-
-
?
L-alanine + pimeloyl-CoA
-
719127
Escherichia coli
8-amino-7-oxononanoate + CoA + CO2
-
-
-
?
L-alanine + pimeloyl-CoA
-
719127
Hungateiclostridium thermocellum
8-amino-7-oxononanoate + CoA + CO2
-
-
-
?
L-alanine + pimeloyl-CoA
-
719127
Thermosynechococcus elongatus
8-amino-7-oxononanoate + CoA + CO2
-
-
-
?
L-alanine + pimeloyl-CoA
no activity observed with acetyl-CoA, no activity observed with glycine or L-serine
719127
Aquifex aeolicus
8-amino-7-oxononanoate + CoA + CO2
-
-
-
?
L-alanine + pimeloyl-CoA
no activity observed with acetyl-CoA, no activity observed with glycine or L-serine
719127
Geobacillus kaustophilus
8-amino-7-oxononanoate + CoA + CO2
-
-
-
?
L-alanine + pimeloyl-CoA
no activity observed with L-serine
719127
Symbiobacterium thermophilum
8-amino-7-oxononanoate + CoA + CO2
-
-
-
?
L-alanine + pimeloyl-CoA
no activity observed with acetyl-CoA, no activity observed with glycine or L-serine
719127
Geobacillus kaustophilus JCM 12893
8-amino-7-oxononanoate + CoA + CO2
-
-
-
?
L-alanine + pimeloyl-CoA
-
719127
Hungateiclostridium thermocellum ATCC 27405
8-amino-7-oxononanoate + CoA + CO2
-
-
-
?
L-alanine + pimeloyl-CoA
no activity observed with L-serine
719127
Symbiobacterium thermophilum IAM14863
8-amino-7-oxononanoate + CoA + CO2
-
-
-
?
Subunits (protein specific)
Subunits
Commentary
Organism
?
x * 45000, SDS-PAGE
Aquifex aeolicus
?
x * 44000, SDS-PAGE
Escherichia coli
?
x * 44000, SDS-PAGE
Geobacillus kaustophilus
?
x * 45000, SDS-PAGE
Hungateiclostridium thermocellum
?
x * 46000, SDS-PAGE
Symbiobacterium thermophilum
?
x * 45000, SDS-PAGE
Thermosynechococcus elongatus
Temperature Optimum [°C] (protein specific)
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
30
-
-
Escherichia coli
50
60
-
Aquifex aeolicus
50
60
-
Geobacillus kaustophilus
50
60
-
Hungateiclostridium thermocellum
50
60
-
Symbiobacterium thermophilum
50
60
-
Thermosynechococcus elongatus
Temperature Stability [°C] (protein specific)
Temperature Stability Minimum [°C]
Temperature Stability Maximum [°C]
Commentary
Organism
40
-
stable for one h
Escherichia coli
55
-
stable for one h
Symbiobacterium thermophilum
65
-
stable for one h
Thermosynechococcus elongatus
70
-
stable for one h
Hungateiclostridium thermocellum
75
-
stable for one h
Geobacillus kaustophilus
93
-
stable for one h
Aquifex aeolicus
KCat/KM [mM/s]
kcat/KM Value [1/mMs-1]
kcat/KM Value Maximum [1/mMs-1]
Substrate
Commentary
Organism
Structure
0.014
-
L-alanine
pH 6.0, 60°C
Symbiobacterium thermophilum
0.984
-
L-alanine
pH 6.0, 60°C
Geobacillus kaustophilus
1.5
-
pimeloyl-CoA
pH 6.0, 60°C
Symbiobacterium thermophilum
2.4
-
pimeloyl-CoA
pH not specified in the publication, temperature not specified in the publication
Escherichia coli
4.9
-
pimeloyl-CoA
pH 6.0, 60°C
Geobacillus kaustophilus
7.33
-
L-alanine
pH 6.0, 60°C
Aquifex aeolicus
213
-
pimeloyl-CoA
pH 6.0, 60°C
Aquifex aeolicus
KCat/KM [mM/s] (protein specific)
KCat/KM Value [1/mMs-1]
KCat/KM Value Maximum [1/mMs-1]
Substrate
Commentary
Organism
Structure
0.014
-
L-alanine
pH 6.0, 60°C
Symbiobacterium thermophilum
0.984
-
L-alanine
pH 6.0, 60°C
Geobacillus kaustophilus
1.5
-
pimeloyl-CoA
pH 6.0, 60°C
Symbiobacterium thermophilum
2.4
-
pimeloyl-CoA
pH not specified in the publication, temperature not specified in the publication
Escherichia coli
4.9
-
pimeloyl-CoA
pH 6.0, 60°C
Geobacillus kaustophilus
7.33
-
L-alanine
pH 6.0, 60°C
Aquifex aeolicus
213
-
pimeloyl-CoA
pH 6.0, 60°C
Aquifex aeolicus
Other publictions for EC 2.3.1.47
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
736245
Fan
Structure and function of Myco ...
Mycolicibacterium smegmatis, Mycolicibacterium smegmatis ATCC 700084
Int. J. Biochem. Cell Biol.
58
71-80
2015
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1
1
1
-
-
-
-
-
-
-
2
-
6
-
-
-
-
-
-
-
-
2
1
-
-
-
-
-
-
-
1
-
-
-
-
1
1
1
1
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
2
1
-
-
-
-
-
-
-
-
-
2
2
-
-
-
736946
Hahn
Triazolyl phenyl disulfides: 8 ...
Arabidopsis thaliana
Pestic. Biochem. Physiol.
125
78-83
2015
-
1
1
-
-
-
8
-
-
-
-
1
-
3
-
-
1
-
-
1
-
-
1
-
1
-
-
-
1
-
-
-
-
-
5
-
1
1
-
-
-
-
5
8
-
-
-
-
-
1
-
-
-
1
-
1
-
-
1
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
735394
Fan
Purification and X-ray crystal ...
Mycolicibacterium smegmatis, Mycolicibacterium smegmatis ATCC 700084
Acta Crystallogr. Sect. F
70
1372-1375
2014
-
-
1
1
-
-
-
-
-
-
1
2
-
4
-
-
1
-
-
-
-
-
2
1
-
-
-
-
-
-
-
1
-
-
-
-
-
1
1
1
-
-
-
-
-
-
-
-
1
2
-
-
-
1
-
-
-
-
2
1
-
-
-
-
-
-
-
-
-
1
1
-
-
-
719127
Kubota
Detection and characterization ...
Aquifex aeolicus, Escherichia coli, Geobacillus kaustophilus, Geobacillus kaustophilus JCM 12893, Hungateiclostridium thermocellum, Hungateiclostridium thermocellum ATCC 27405, Symbiobacterium thermophilum, Symbiobacterium thermophilum IAM14863, Thermosynechococcus elongatus
Biosci. Biotechnol. Biochem.
76
685-690
2012
-
-
6
-
-
-
-
8
-
-
6
-
-
24
-
-
6
-
-
-
6
-
15
6
6
-
6
-
-
-
-
6
-
-
-
-
-
6
6
-
-
-
-
-
-
8
-
-
6
-
-
-
-
6
-
-
6
-
15
6
6
-
6
-
-
-
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Izumi
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Distribution of 7-keto-8-amino ...
Alcaligenes faecalis, Bacillus subtilis, Citrobacter freundii, Enterobacter cloacae, Erwinia aroidea, Escherichia coli, Klebsiella aerogenes, Kocuria rosea, Lysinibacillus sphaericus, Pseudomonas fluorescens
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Izumi
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Partial purification and some ...
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Synthesis of 7-oxo-8-aminopela ...
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