BRENDA - Enzyme Database show
show all sequences of 2.3.1.47

Broad substrate stereospecificity of the Mycobacterium tuberculosis 7-keto-8-aminopelargonic acid synthase: spectroscopic and kinetic studies

Bhor, V.M.; Dev, S.; Vasanthakumar, G.R.; Kumar, P.; Sinha, S.; Surolia, A.; J. Biol. Chem. 281, 25076-25088 (2006)

Data extracted from this reference:

Cloned(Commentary)
Commentary
Organism
gene Rv1569, overexpression of His-tagged enzyme in Escherichia coli strain BL21(DE3)
Mycobacterium tuberculosis
Inhibitors
Inhibitors
Commentary
Organism
Structure
D-KAPA
product inhibition
Mycobacterium tuberculosis
additional information
no inhibition by D-alanine
Mycobacterium tuberculosis
KM Value [mM]
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
additional information
-
additional information
stopped-flow kinetics of enzyme interaction with L-alanine and D-alanine, steady-state kinetics and thermodynamics
Mycobacterium tuberculosis
0.0015
-
pimeloyl-CoA
pH 7.7, 25°C, recombinant enzyme
Mycobacterium tuberculosis
0.2015
-
D-alanine
pH 7.7, 25°C, recombinant enzyme, with pimeloyl-CoA
Mycobacterium tuberculosis
0.4675
-
L-alanine
pH 7.7, 25°C, recombinant enzyme, with pimeloyl-CoA
Mycobacterium tuberculosis
Molecular Weight [Da]
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
42000
-
x * 42000, recombinant His-tagged enzyme, SDS-PAGE, x * 42249, recombinant His-tagged enzyme, mass spectrometry, x * 42194, amino acid sequence calculation
Mycobacterium tuberculosis
42194
-
x * 42000, recombinant His-tagged enzyme, SDS-PAGE, x * 42249, recombinant His-tagged enzyme, mass spectrometry, x * 42194, amino acid sequence calculation
Mycobacterium tuberculosis
42249
-
x * 42000, recombinant His-tagged enzyme, SDS-PAGE, x * 42249, recombinant His-tagged enzyme, mass spectrometry, x * 42194, amino acid sequence calculation
Mycobacterium tuberculosis
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
6-carboxyhexanoyl-CoA + L-alanine
Mycobacterium tuberculosis
first committed step in the biotin biosynthesis pathway
8-amino-7-oxononanoate + CoA + CO2
-
-
?
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Mycobacterium tuberculosis
-
gene Rv1569
-
Purification (Commentary)
Commentary
Organism
recombinant His-tagged enzyme from Escherichia coli strain BL21(DE3) by nickel affiinity chromatography and gel filtration to homogeneity
Mycobacterium tuberculosis
Reaction
Reaction
Commentary
Organism
pimeloyl-[acyl-carrier protein] + L-alanine = 8-amino-7-oxononanoate + CO2 + holo-[acyl-carrier protein]
formation of an external intermediate beta-ketoacid pyridoxal-5'-phosphate aldimine, preference for L-alanine
Mycobacterium tuberculosis
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
6-carboxyhexanoyl-CoA + D-alanine
the L-isomer of the amino acid is preferred, D-alanine shows 5fold slower reaction, interaction analysis, overview
674626
Mycobacterium tuberculosis
8-amino-7-oxononanoate + CoA + CO2
i.e. D-KAPA
-
-
?
6-carboxyhexanoyl-CoA + L-alanine
first committed step in the biotin biosynthesis pathway
674626
Mycobacterium tuberculosis
8-amino-7-oxononanoate + CoA + CO2
-
-
-
?
6-carboxyhexanoyl-CoA + L-alanine
the L-isomer of the amino acid is preferred giving a 5fold faster reaction, interaction analysis, overview
674626
Mycobacterium tuberculosis
8-amino-7-oxononanoate + CoA + CO2
i.e. L-KAPA
-
-
?
additional information
pimeloyl-CoA forms a quinonoid with L- or D-KAPA
674626
Mycobacterium tuberculosis
?
-
-
-
-
pimeloyl-CoA + D-alanine
-
674626
Mycobacterium tuberculosis
?
-
-
-
?
pimeloyl-CoA + L-alanine
-
674626
Mycobacterium tuberculosis
?
-
-
-
?
Subunits
Subunits
Commentary
Organism
?
x * 42000, recombinant His-tagged enzyme, SDS-PAGE, x * 42249, recombinant His-tagged enzyme, mass spectrometry, x * 42194, amino acid sequence calculation
Mycobacterium tuberculosis
Temperature Optimum [°C]
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
25
-
assay at
Mycobacterium tuberculosis
Turnover Number [1/s]
Turnover Number Minimum [1/s]
Turnover Number Maximum [1/s]
Substrate
Commentary
Organism
Structure
0.0036
-
D-alanine
pH 7.7, 25°C, recombinant enzyme, with pimeloyl-CoA
Mycobacterium tuberculosis
0.004
-
pimeloyl-CoA
pH 7.7, 25°C, recombinant enzyme
Mycobacterium tuberculosis
0.007
-
L-alanine
pH 7.7, 25°C, recombinant enzyme, with pimeloyl-CoA
Mycobacterium tuberculosis
pH Optimum
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
7.7
-
assay at
Mycobacterium tuberculosis
Cofactor
Cofactor
Commentary
Organism
Structure
pyridoxal 5'-phosphate
dependent on
Mycobacterium tuberculosis
Ki Value [mM]
Ki Value [mM]
Ki Value maximum [mM]
Inhibitor
Commentary
Organism
Structure
0.115
-
D-KAPA
pH 7.7, 25°C, recombinant enzyme
Mycobacterium tuberculosis
Cloned(Commentary) (protein specific)
Commentary
Organism
gene Rv1569, overexpression of His-tagged enzyme in Escherichia coli strain BL21(DE3)
Mycobacterium tuberculosis
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
pyridoxal 5'-phosphate
dependent on
Mycobacterium tuberculosis
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
D-KAPA
product inhibition
Mycobacterium tuberculosis
additional information
no inhibition by D-alanine
Mycobacterium tuberculosis
Ki Value [mM] (protein specific)
Ki Value [mM]
Ki Value maximum [mM]
Inhibitor
Commentary
Organism
Structure
0.115
-
D-KAPA
pH 7.7, 25°C, recombinant enzyme
Mycobacterium tuberculosis
KM Value [mM] (protein specific)
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
additional information
-
additional information
stopped-flow kinetics of enzyme interaction with L-alanine and D-alanine, steady-state kinetics and thermodynamics
Mycobacterium tuberculosis
0.0015
-
pimeloyl-CoA
pH 7.7, 25°C, recombinant enzyme
Mycobacterium tuberculosis
0.2015
-
D-alanine
pH 7.7, 25°C, recombinant enzyme, with pimeloyl-CoA
Mycobacterium tuberculosis
0.4675
-
L-alanine
pH 7.7, 25°C, recombinant enzyme, with pimeloyl-CoA
Mycobacterium tuberculosis
Molecular Weight [Da] (protein specific)
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
42000
-
x * 42000, recombinant His-tagged enzyme, SDS-PAGE, x * 42249, recombinant His-tagged enzyme, mass spectrometry, x * 42194, amino acid sequence calculation
Mycobacterium tuberculosis
42194
-
x * 42000, recombinant His-tagged enzyme, SDS-PAGE, x * 42249, recombinant His-tagged enzyme, mass spectrometry, x * 42194, amino acid sequence calculation
Mycobacterium tuberculosis
42249
-
x * 42000, recombinant His-tagged enzyme, SDS-PAGE, x * 42249, recombinant His-tagged enzyme, mass spectrometry, x * 42194, amino acid sequence calculation
Mycobacterium tuberculosis
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
6-carboxyhexanoyl-CoA + L-alanine
Mycobacterium tuberculosis
first committed step in the biotin biosynthesis pathway
8-amino-7-oxononanoate + CoA + CO2
-
-
?
Purification (Commentary) (protein specific)
Commentary
Organism
recombinant His-tagged enzyme from Escherichia coli strain BL21(DE3) by nickel affiinity chromatography and gel filtration to homogeneity
Mycobacterium tuberculosis
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
6-carboxyhexanoyl-CoA + D-alanine
the L-isomer of the amino acid is preferred, D-alanine shows 5fold slower reaction, interaction analysis, overview
674626
Mycobacterium tuberculosis
8-amino-7-oxononanoate + CoA + CO2
i.e. D-KAPA
-
-
?
6-carboxyhexanoyl-CoA + L-alanine
first committed step in the biotin biosynthesis pathway
674626
Mycobacterium tuberculosis
8-amino-7-oxononanoate + CoA + CO2
-
-
-
?
6-carboxyhexanoyl-CoA + L-alanine
the L-isomer of the amino acid is preferred giving a 5fold faster reaction, interaction analysis, overview
674626
Mycobacterium tuberculosis
8-amino-7-oxononanoate + CoA + CO2
i.e. L-KAPA
-
-
?
additional information
pimeloyl-CoA forms a quinonoid with L- or D-KAPA
674626
Mycobacterium tuberculosis
?
-
-
-
-
pimeloyl-CoA + D-alanine
-
674626
Mycobacterium tuberculosis
?
-
-
-
?
pimeloyl-CoA + L-alanine
-
674626
Mycobacterium tuberculosis
?
-
-
-
?
Subunits (protein specific)
Subunits
Commentary
Organism
?
x * 42000, recombinant His-tagged enzyme, SDS-PAGE, x * 42249, recombinant His-tagged enzyme, mass spectrometry, x * 42194, amino acid sequence calculation
Mycobacterium tuberculosis
Temperature Optimum [°C] (protein specific)
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
25
-
assay at
Mycobacterium tuberculosis
Turnover Number [1/s] (protein specific)
Turnover Number Minimum [1/s]
Turnover Number Maximum [1/s]
Substrate
Commentary
Organism
Structure
0.0036
-
D-alanine
pH 7.7, 25°C, recombinant enzyme, with pimeloyl-CoA
Mycobacterium tuberculosis
0.004
-
pimeloyl-CoA
pH 7.7, 25°C, recombinant enzyme
Mycobacterium tuberculosis
0.007
-
L-alanine
pH 7.7, 25°C, recombinant enzyme, with pimeloyl-CoA
Mycobacterium tuberculosis
pH Optimum (protein specific)
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
7.7
-
assay at
Mycobacterium tuberculosis
Other publictions for EC 2.3.1.47
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
736245
Fan
Structure and function of Myco ...
Mycolicibacterium smegmatis, Mycolicibacterium smegmatis ATCC 700084
Int. J. Biochem. Cell Biol.
58
71-80
2015
-
1
1
1
-
-
-
-
-
-
-
2
-
6
-
-
-
-
-
-
-
-
2
1
-
-
-
-
-
-
-
1
-
-
-
-
1
1
1
1
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
2
1
-
-
-
-
-
-
-
-
-
2
2
-
-
-
736946
Hahn
Triazolyl phenyl disulfides: 8 ...
Arabidopsis thaliana
Pestic. Biochem. Physiol.
125
78-83
2015
-
1
1
-
-
-
8
-
-
-
-
1
-
3
-
-
1
-
-
1
-
-
1
-
1
-
-
-
1
-
-
-
-
-
5
-
1
1
-
-
-
-
5
8
-
-
-
-
-
1
-
-
-
1
-
1
-
-
1
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
735394
Fan
Purification and X-ray crystal ...
Mycolicibacterium smegmatis, Mycolicibacterium smegmatis ATCC 700084
Acta Crystallogr. Sect. F
70
1372-1375
2014
-
-
1
1
-
-
-
-
-
-
1
2
-
4
-
-
1
-
-
-
-
-
2
1
-
-
-
-
-
-
-
1
-
-
-
-
-
1
1
1
-
-
-
-
-
-
-
-
1
2
-
-
-
1
-
-
-
-
2
1
-
-
-
-
-
-
-
-
-
1
1
-
-
-
719127
Kubota
Detection and characterization ...
Aquifex aeolicus, Escherichia coli, Geobacillus kaustophilus, Geobacillus kaustophilus JCM 12893, Hungateiclostridium thermocellum, Hungateiclostridium thermocellum ATCC 27405, Symbiobacterium thermophilum, Symbiobacterium thermophilum IAM14863, Thermosynechococcus elongatus
Biosci. Biotechnol. Biochem.
76
685-690
2012
-
-
6
-
-
-
-
8
-
-
6
-
-
24
-
-
6
-
-
-
6
-
15
6
6
-
6
-
-
-
-
6
-
-
-
-
-
6
6
-
-
-
-
-
-
8
-
-
6
-
-
-
-
6
-
-
6
-
15
6
6
-
6
-
-
-
-
-
-
-
-
-
7
7
719203
Cho
-
The identification of binding ...
Arabidopsis thaliana
Bull. Korean Chem. Soc.
33
1597-1602
2012
-
-
-
-
-
-
17
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
17
-
-
-
1
-
-
-
17
17
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
718696
Turbeville
Functional asymmetry for the a ...
Escherichia coli
Arch. Biochem. Biophys.
511
107-117
2011
-
-
1
-
1
-
-
4
-
-
-
-
-
1
-
-
1
-
-
-
-
-
1
1
-
-
-
2
-
-
-
1
-
-
-
-
-
1
1
-
1
-
-
-
-
4
-
-
-
-
-
-
-
1
-
-
-
-
1
1
-
-
-
2
-
-
-
-
-
-
-
-
4
4
720623
Hwang
-
Validation of 7-keto-8-aminope ...
Arabidopsis thaliana
Pestic. Biochem. Physiol.
97
24-31
2010
-
-
1
-
-
-
1
-
-
-
1
-
-
1
-
-
1
-
-
2
-
-
1
1
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
1
1
-
-
-
-
1
-
-
-
-
1
-
2
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
702483
Mann
Inhibition of 7,8-diaminopelar ...
Escherichia coli, Escherichia coli C268, Mycobacterium tuberculosis
Biochimie
91
826-834
2009
-
2
2
-
-
-
3
2
-
-
-
3
-
4
-
-
-
-
-
-
-
-
6
2
-
-
-
-
-
-
-
2
11
-
-
-
2
2
2
-
-
-
-
3
11
2
-
-
-
3
-
-
-
-
-
-
-
-
6
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
673041
Kerbarh
Mechanism of alpha-oxoamine sy ...
Escherichia coli
Chem. Commun. (Camb. )
2006
60-62
2006
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
1
-
-
-
-
3
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
674626
Bhor
Broad substrate stereospecific ...
Mycobacterium tuberculosis
J. Biol. Chem.
281
25076-25088
2006
-
-
1
-
-
-
2
4
-
-
3
1
-
3
-
-
1
1
-
-
-
-
6
1
1
-
-
3
1
-
-
1
1
-
-
-
-
1
1
-
-
-
-
2
1
4
-
-
3
1
-
-
-
1
-
-
-
-
6
1
1
-
-
3
1
-
-
-
-
-
-
-
-
-
676274
Alexeev
Suicide inhibition of alpha-ox ...
Escherichia coli
Org. Biomol. Chem.
4
1209-1212
2006
-
-
-
1
-
-
1
-
-
-
1
1
-
1
-
-
-
1
-
-
-
-
1
2
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
1
-
-
-
1
-
-
-
-
1
1
-
-
-
-
-
-
-
-
1
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
676580
Pinon
Biotin synthesis in plants. Th ...
Arabidopsis thaliana
Plant Physiol.
139
1666-1676
2005
-
-
1
-
1
-
-
3
1
-
2
2
-
5
-
-
1
1
-
-
1
-
3
1
1
-
-
2
1
-
-
1
-
-
-
-
-
1
1
-
1
-
-
-
-
3
1
-
2
2
-
-
-
1
-
-
1
-
3
1
1
-
-
2
1
-
-
-
-
-
-
-
-
-
487058
Webster
Mechanism of 8-amino-7-oxonona ...
Escherichia coli
Biochemistry
39
516-528
2000
-
-
1
1
-
-
1
2
-
-
1
2
-
2
-
-
1
1
-
-
-
-
2
-
1
-
-
1
1
-
-
1
-
-
-
-
-
1
1
1
-
-
-
1
-
2
-
-
1
2
-
-
-
1
-
-
-
-
2
-
1
-
-
1
1
-
-
-
-
-
-
-
-
-
487054
Ploux
Slow-binding and competitive i ...
Lysinibacillus sphaericus
Eur. J. Biochem.
259
63-70
1999
-
1
-
-
-
-
5
-
-
-
-
3
-
1
-
-
1
1
-
-
-
-
3
-
-
-
-
-
1
-
-
1
4
-
-
-
1
-
1
-
-
-
-
5
4
-
-
-
-
3
-
-
-
1
-
-
-
-
3
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
487056
Webster
Characterization of 8-amino-7- ...
Escherichia coli, Lysinibacillus sphaericus
Biochem. Soc. Trans.
26
S268
1998
-
-
1
1
-
-
-
2
-
-
1
4
-
2
-
-
1
2
-
-
-
-
4
1
-
-
-
1
-
-
-
2
-
-
-
-
-
1
2
1
-
-
-
-
-
2
-
-
1
4
-
-
-
1
-
-
-
-
4
1
-
-
-
1
-
-
-
-
-
-
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487057
Alexeev
The crystal structure of 8-ami ...
Escherichia coli
J. Mol. Biol.
284
401-419
1998
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487053
Ploux
Mechanistic studies on the 8-a ...
Lysinibacillus sphaericus
Eur. J. Biochem.
236
301-308
1996
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487055
Spinelli
Crystallization and preliminar ...
Lysinibacillus sphaericus
Acta Crystallogr. Sect. D
52
866-868
1996
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487048
Ploux
The 8-amino-7-oxopelargonate s ...
Lysinibacillus sphaericus
Biochem. J.
283
327-331
1992
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487049
Otsuka
The Escherichia coli biotin bi ...
Escherichia coli
J. Biol. Chem.
263
19577-19585
1988
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1333
Izumi
-
Characterization of biotin bio ...
Lipomyces starkeyi, Lysinibacillus sphaericus, Lysinibacillus sphaericus IFO 3525, Sporidiobolus salmonicolor, Sporobolomyces coprophilus
Agric. Biol. Chem.
45
1983-1989
1981
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487051
Izumi
-
Distribution of 7-keto-8-amino ...
Alcaligenes faecalis, Bacillus subtilis, Citrobacter freundii, Enterobacter cloacae, Erwinia aroidea, Escherichia coli, Klebsiella aerogenes, Kocuria rosea, Lysinibacillus sphaericus, Pseudomonas fluorescens
Agric. Biol. Chem.
37
1335-1340
1973
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487052
Izumi
-
Partial purification and some ...
Lysinibacillus sphaericus
Agric. Biol. Chem.
37
1327-1333
1973
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487047
Eidenberg
Synthesis of 7-oxo-8-aminopela ...
Escherichia coli
J. Bacteriol.
96
1291-1297
1968
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