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Literature summary for 2.3.1.45 extracted from

  • Diaz, S.; Higa, H.H.; Varki, A.
    Glycoprotein sialate 7(9)-O-acetyltransferase from rat liver Golgi vesicles (1989), Methods Enzymol., 179, 416-422.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
CoA inhibition of transfer to endogenous acceptors, no inhibition of transfer from acetyl intermediate to free acetylneuraminate Rattus norvegicus
diethyl dicarbonate
-
Rattus norvegicus
N-bromosuccinimide
-
Rattus norvegicus
Triton X-100 above 0.02% Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0028
-
acetyl-CoA cosubstrate glycosidically bound N-acetylneuraminate Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol equally distributed between membrane and cytosolic fraction Rattus norvegicus 5829
-
Golgi vesicle equally distributed between membrane and cytosolic fraction Rattus norvegicus
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acetyl-CoA + sialic acid Rattus norvegicus pathway, overview CoA + N-acetyl-7-O(or 9-O-)-acetylneuraminate
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Reaction

Reaction Comment Organism Reaction ID
acetyl-CoA + N-acetylneuraminate = CoA + N-acetyl-7-O(or 9-O)-acetylneuraminate 7-O-acetyl groups can migrate to the 9-position Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Rattus norvegicus
-

Storage Stability

Storage Stability Organism
-70°C, prelabeled Golgi vesicles, 4 days Rattus norvegicus
frozen Golgi vesicles are stable for 3-6 months Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-CoA + N-acetylneuraminate glycosidically bound N-acetylneuraminate Rattus norvegicus CoA + N-acetyl-7-O(or 9-O-)-acetylneuraminate
-
?
acetyl-CoA + N-acetylneuraminate acetylneuraminate bound to sialic acids Rattus norvegicus CoA + N-acetyl-7-O(or 9-O-)-acetylneuraminate
-
?
acetyl-CoA + N-acetylneuraminate free acetylneuraminate Rattus norvegicus CoA + N-acetyl-7-O(or 9-O-)-acetylneuraminate
-
?
acetyl-CoA + sialic acid pathway, overview Rattus norvegicus CoA + N-acetyl-7-O(or 9-O-)-acetylneuraminate
-
?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.5
-
assay at Rattus norvegicus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00074
-
CoA
-
Rattus norvegicus