Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
blood plasma | - |
Mus musculus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
serine palmitoyltransferase deficient mice, and sphingomyelin synthase deficient mice, both of which have below normal sphingomyelin (SM)/phosphatidylcholine (PC) ratios, show significantly elevated LCAT activities when assayed with the endogenous substrates. LDL receptor knockout mice, and apo E knockout mice, both of which have high SM/PC ratios, have reduced LCAT activities | Mus musculus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | for the endogenous assay, the plasma sample is equilibrated with human serum albumin-3H cholesterol emulsion | Mus musculus | ? | - |
? | |
additional information | for the exogenous substrate assay, proteoliposomes containing 14C-labeled cholesterol, egg PC, and apo AI at molar ratios of 15:300:1 are prepared. Plasma sample is incubated with proteoliposome substrate | Mus musculus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
LCAT | - |
Mus musculus |
lecithin/cholesterol acyltransferase | - |
Mus musculus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Mus musculus |
General Information | Comment | Organism |
---|---|---|
malfunction | serine palmitoyltransferase deficient mice, and sphingomyelin synthase deficient mice, both of which have below normal sphingomyelin (SM)/phosphatidylcholine (PC) ratios, show significantly elevated LCAT activities when assayed with the endogenous substrates. LDL receptor knockout mice, and apo E knockout mice, both of which have high SM/PC ratios, have reduced LCAT activities | Mus musculus |