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Literature summary for 2.3.1.43 extracted from

  • Jones, M.K.; Catte, A.; Li, L.; Segrest, J.P.
    Dynamics of activation of lecithin:cholesterol acyltransferase by apolipoprotein A-I (2009), Biochemistry, 48, 11196-11210.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.3.1.43

Activating Compound

Activating Compound Comment Organism Structure
apolipoprotein A-I the central helix 4-helix 5-helix 6 domain in apoA-I is the unique structural element that provides full specificity to apoA-I activation of LCAT through substantially more LCAT binding and substrate binding and presentation to LCAT thorough the presentation tunnel, molecular dynamics, role of apoA-I in activation of LCAT involved simulations of discoidal particles, overview Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
additional information LCAT shows product inhibition Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular
-
 Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
phosphatidylcholine + cholesterol Homo sapiens
-
 cholesteryl ester + lysophosphatidylcholine
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
blood plasma
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information cholesteryl ester-rich HDL particles bind LCAT effectively and contain apolipoprotein A-I and ample phosphatidylcholine and unesterified cholesterol substrates but exhibit relatively low reactivity with LCAT since the cholesteryl ester products cannot be removed from the active site Homo sapiens ?
-
 ?
phosphatidylcholine + cholesterol
-
 Homo sapiens cholesteryl ester + lysophosphatidylcholine
-
 ?
phosphatidylcholine + cholesterol enzyme with bound activator apolipoprotein A-I, structure-function relationship and analysis, molecular dynamics and simulations, overview Homo sapiens cholesteryl ester + lysophosphatidylcholine
-
 ?

Synonyms

Synonyms Comment Organism
LCAT
-
 Homo sapiens
lecithin:cholesterol acyltransferase
-
 Homo sapiens