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Literature summary for 2.3.1.42 extracted from
- Purification of peroxisomal acyl-CoA:dihydroxyacetonephosphate acyltransferase from human placenta (1994), Biochim. Biophys. Acta, 1206, 27-34.
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | enzyme amount is reduced by 90% in Zellweger syndrome | Homo sapiens |
General Stability
| General Stability | Organism |
|---|---|
| dipalmitoylphosphatidylcholine stabilizes purified enzyme | Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| peroxisome | - |
Homo sapiens | 5777 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 60000 | 80000 | gel filtration | Homo sapiens |
| 65000 | - |
1 * 65000, SDS-PAGE | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Homo sapiens | enzyme amount is reduced by 90% in Zellweger syndrome | ? | - |
? |  |
| palmitoyl-CoA + dihydroxyacetone phosphate | Homo sapiens | - |
CoA + monopalmitoyldihydroxyacetone phosphate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| peroxisomal from placenta, with 3-[(3-cholamidopropyl)dimethylammonio]-1-propanesulfonate, i.e. CHAPS, plus 1 M KCl | Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Homo sapiens | - |
| placenta | - |
Homo sapiens | - |
| skin fibroblast | - |
Homo sapiens | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.00061 | - |
purified enzyme | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acyl-CoA + dihydroxyacetone phosphate | - |
Homo sapiens | CoA + acyldihydroxyacetone phosphate | - |
? | |
| cis-9-hexadecenoyl-CoA + dihydroxyacetone phosphate | - |
Homo sapiens | CoA + cis-9-hexadecenoyldihydroxyacetone phosphate | - |
? | |
| additional information | enzyme amount is reduced by 90% in Zellweger syndrome | Homo sapiens | ? | - |
? | |
| palmitoyl-CoA + dihydroxyacetone phosphate | - |
Homo sapiens | CoA + monopalmitoyldihydroxyacetone phosphate | - |
? | |
| palmitoyl-CoA + dihydroxyacetone phosphate | best substrate | Homo sapiens | CoA + monopalmitoyldihydroxyacetone phosphate | - |
? | |
| tetradecanoyl-CoA + dihydroxyacetone phosphate | i.e. myristoyl-CoA | Homo sapiens | CoA + tetradecanoyldihydroxyacetone phosphate | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| monomer | 1 * 65000, SDS-PAGE | Homo sapiens |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| DHAPAT | - |
Homo sapiens |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Homo sapiens |
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Release 2023.1 (January 2023)
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