Application | Comment | Organism |
---|---|---|
drug development | the enzyme is a target for antibacterial drugs | Staphylococcus aureus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | in vivo inhibition assays, no inhibition by platensimycin | Staphylococcus aureus | |
platencin | exhibits a broad-spectrum Gram-positive antibacterial activity through inhibition of fatty acid biosynthesis, targets the two essential proteins, beta-ketoacyl-[acyl carrier protein] synthase II and III, i.e. FabF and FabH, purified FabH IC50: 0.016 mM, overview | Staphylococcus aureus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Staphylococcus aureus | inhibition of FabH leads to loss of accumulation of acetoacetyl-ACP | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Staphylococcus aureus | - |
methicillin-resistant and vancomycin-resistant strains | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
development of an elongation assay with FabF, EC 2.3.1.179, and FabH | Staphylococcus aureus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | inhibition of FabH leads to loss of accumulation of acetoacetyl-ACP | Staphylococcus aureus | ? | - |
? | |
additional information | FabH produces C14 long-chain beta-ketoacyl-ACP | Staphylococcus aureus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
beta-ketoacyl-[acyl carrier protein (ACP)] synthase III | - |
Staphylococcus aureus |
FabH | - |
Staphylococcus aureus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
30 | - |
assay at | Staphylococcus aureus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7 | - |
assay at | Staphylococcus aureus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.016 | - |
exhibits a broad-spectrum Gram-positive antibacterial activity through inhibition of fatty acid biosynthesis, targets the two essential proteins, beta-ketoacyl-[acyl carrier protein] synthase II and III, i.e. FabF and FabH, purified FabH IC50: 0.016 mM, o | Staphylococcus aureus | platencin |