Protein Variants | Comment | Organism |
---|---|---|
R161A | 69.6% of wild-type activity | Mycobacterium tuberculosis |
R46A | 7.3% of wild-type activity | Mycobacterium tuberculosis |
R46A/R161A | 0.3% of wild-type activity | Mycobacterium tuberculosis |
T97F | no enzymic activity | Mycobacterium tuberculosis |
W42A | 21.5% of wild-type activity | Mycobacterium tuberculosis |
W42A/R161A | 0.2% of wild-type activity | Mycobacterium tuberculosis |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0023 | - |
dodecanoyl-[acyl-carrier protein] | pH 7.0, 37°C | Mycobacterium tuberculosis |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mycobacterium tuberculosis | - |
- |
- |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.0017 | - |
substrate hexanoyl-[acyl-carrier protein], pH 7.0, 37°C | Mycobacterium tuberculosis |
0.0055 | - |
substrate octanoyl-[acyl-carrier protein], pH 7.0, 37°C | Mycobacterium tuberculosis |
0.0062 | - |
substrate decanoyl-[acyl-carrier protein], pH 7.0, 37°C | Mycobacterium tuberculosis |
0.0072 | - |
substrate dodecanoyl-[acyl-carrier protein], pH 7.0, 37°C | Mycobacterium tuberculosis |
0.009 | - |
substrate eicosanoyl-[acyl-carrier-protein], pH 7.0, 37°C | Mycobacterium tuberculosis |
0.0093 | - |
substrate palmitoyl-[acyl-carrier protein], pH 7.0, 37°C | Mycobacterium tuberculosis |
0.0095 | - |
substrate myristoyl-[acyl-carrier protein], pH 7.0, 37°C | Mycobacterium tuberculosis |
0.0104 | - |
substrate octadecanoyl-[acyl-carrier-protein], pH 7.0, 37°C | Mycobacterium tuberculosis |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
decanoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] | - |
Mycobacterium tuberculosis | dodecanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein] | - |
? | |
dodecanoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] | - |
Mycobacterium tuberculosis | 3-oxotetradecanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein] | - |
? | |
eicosanoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] | - |
Mycobacterium tuberculosis | 3-oxodocosanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein] | - |
? | |
hexanoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] | - |
Mycobacterium tuberculosis | 3-oxooctanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein] | - |
? | |
additional information | enzyme is able to use Escherichia coli acyl-carrier protein. Enzyme extends longer, physiologically relevant acyl-CoA primers when paired with its native acyl-carrier protein than with Escherichia coli acyl-carrier protein | Mycobacterium tuberculosis | ? | - |
? | |
myristoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] | - |
Mycobacterium tuberculosis | 3-oxohexadecanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein] | - |
? | |
octadecanoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] | - |
Mycobacterium tuberculosis | 3-oxoeicosanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein] | - |
? | |
octanoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] | - |
Mycobacterium tuberculosis | 3-oxodecanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein] | - |
? | |
palmitoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] | - |
Mycobacterium tuberculosis | 3-oxooctadecanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein] | - |
? |