Literature summary for 2.3.1.39 extracted from

Li, Z.; Meng, T.; Ling, X.; Li, J.; Zheng, C.; Shi, Y.; Chen, Z.; Li, Z.; Li, Q.; Lu, Y.; He, N.
Overexpression of malonyl-CoA ACP transacylase in Schizochytrium sp. to improve polyunsaturated fatty acid production (2018), J. Agric. Food Chem., 66, 5382-5391 .

Search for more literature for 2.3.1.39

Application

Application	Comment	Organism
synthesis	an effective metabolic engineering strategy for industrial polyunsaturated fatty acid production is provided	Schizochytrium sp. MYA1381

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
malonyl-CoA + an [acyl-carrier protein]	Schizochytrium sp. MYA1381	-	CoA + a malonyl-[acyl-carrier protein]	-	?

Organism

Organism	UniProt	Comment	Textmining
Schizochytrium sp. MYA1381	A0A345ANG7	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
malonyl-CoA + an [acyl-carrier protein]	-	Schizochytrium sp. MYA1381	CoA + a malonyl-[acyl-carrier protein]	-	?

Synonyms

Synonyms	Comment	Organism
malonyl-CoA: ACP transacylase	-	Schizochytrium sp. MYA1381
MAT	-	Schizochytrium sp. MYA1381

General Information

General Information	Comment	Organism
metabolism	enzyme overexpression can weaken tricarboxylic acid, accelerate glucose absorption by improving membrane fluidity and permeability, and enhance carbon flux to the polyunsaturated fatty acid synthesis. Lipid and polyunsaturated fatty acid concentrations are increased by 10.1 and 24.5% with enzyme overexpression, respectively. Docosahexaenoic acid and eicosapentaenoic acid yield are enhanced 81.5 and 172.5%, respectively	Schizochytrium sp. MYA1381
metabolism	lipid and polyunsaturated fatty acid concentration are increased by 10.1 and 24.5% with malonyl-CoA: ACP transacylase overexpression, respectively. The intracellular tricarboxylic acid cycle is weakened and glucose absorption is accelerated in the engineered strain. In the mevalonate pathway, intracellular carotene content is decreased, and the carbon flux is redirected toward synthesis of polyunsaturated fatty acid	Schizochytrium sp. MYA1381

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Release 2023.1 (January 2023)