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Literature summary for 2.3.1.39 extracted from

  • Paiva, P.; Sousa, S.; Fernandes, P.; Joao Ramos, M.
    Human Fatty Acid Synthase A Computational study of the transfer of the acyl moieties from mat to the ACP domain (2019), ChemCatChem, 11, 3853-3864 .
No PubMed abstract available

Protein Variants

Protein Variants Comment Organism
R606A the mutation reduces the malonyl transacylase activity and, on the other hand, renders better transferase activity concerning the acetyl moiety Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acetyl-CoA + an [acyl-carrier protein] Homo sapiens
-
CoA + an acetyl-[acyl-carrier protein]
-
?
malonyl-CoA + an [acyl-carrier protein] Homo sapiens
-
CoA + a malonyl-[acyl-carrier protein]
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-CoA + an [acyl-carrier protein]
-
Homo sapiens CoA + an acetyl-[acyl-carrier protein]
-
?
malonyl-CoA + an [acyl-carrier protein]
-
Homo sapiens CoA + a malonyl-[acyl-carrier protein]
-
?

Synonyms

Synonyms Comment Organism
FAS
-
Homo sapiens
fatty acid synthase
-
Homo sapiens
MAT malonyl-acetyl transferase domain of fatty acid synthase Homo sapiens