Application | Comment | Organism |
---|---|---|
drug development | the enzyme is a target for developing broad-spectrum antibiotics | Moraxella catarrhalis |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
apomorphine | - |
Moraxella catarrhalis | |
boldine | - |
Moraxella catarrhalis | |
corytuberine | - |
Moraxella catarrhalis | |
magnoflorine | - |
Moraxella catarrhalis |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
malonyl-CoA + an [acyl-carrier protein] | Moraxella catarrhalis | - |
CoA + a malonyl-[acyl-carrier protein] | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Moraxella catarrhalis | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
malonyl-CoA + an [acyl-carrier protein] | - |
Moraxella catarrhalis | CoA + a malonyl-[acyl-carrier protein] | - |
? |
Synonyms | Comment | Organism |
---|---|---|
FabD | - |
Moraxella catarrhalis |
malonyl-CoA:ACP transacylase | - |
Moraxella catarrhalis |
General Information | Comment | Organism |
---|---|---|
metabolism | the enzyme is an essential enzyme of the fatty acid synthesis II pathway. It performs initiation reaction to form malonyl-ACP, which is a key building block in fatty acid biosynthesis. Aporphine alkaloids can act as antibacterial agents and possible target of these compounds could be the FabD enzyme | Moraxella catarrhalis |