KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.016 | - |
malonyl-CoA | pH 7.5, 37°C | Klebsiella pneumoniae | |
0.016 | - |
methylmalonyl-CoA | pH 7.5, 37°C | Klebsiella pneumoniae |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Klebsiella pneumoniae | O32717 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
malonyl-CoA + acyl-carrier protein | - |
Klebsiella pneumoniae | CoA + malonyl-[acyl-carrier protein] | - |
? | |
methylmalonyl-CoA + acyl-carrier protein | - |
Klebsiella pneumoniae | CoA + methylmalonyl-[acyl-carrier protein] | - |
? | |
additional information | presence of malonyl-CoA:ACP transacylase MdcH is required for catalytic activity of malonate decarboxylase. Substrates for MdcH are malonyl-CoA or methylmalonyl-CoA but not acetyl-CoA. Transfer of the methylmalonyl-residue to the prosthetic group proceeds via the covalent methylmalonyl-MdcH intermediate | Klebsiella pneumoniae | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
tetramer | malonate decarboxylase consists of the four subunits MdcA, MdcD, MdcE and MdcC in an apparent 1:1:1:1 stoichiometry. The preparation contains substoichiometric amounts of malonyl-CoA:ACP transacylase MdcH comigrating on SDS/PAGE with MdcD | Klebsiella pneumoniae |
Synonyms | Comment | Organism |
---|---|---|
MdcH | - |
Klebsiella pneumoniae |