Cloned (Comment) | Organism |
---|---|
expression of the enzyme gene in Escherichia coli | Streptomyces glaucescens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Streptomyces glaucescens | the enzyme is responsible for charging the tetracenomycin M acyl-carrier-protein with malonate in vivo, a key step in the synthesis of the deca(polyketide) precursor of tetracenomycin C. This implies the existence of a functional connection between fatty acid and polyketide metabolism in this bacterium | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Streptomyces glaucescens | - |
produces tetracenomicin C | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
malonyl-CoA + acyl-carrier protein | the recombinant enzyme is able to use E. coli acyl-carrier-protein, Streptomyces glaucescens acyl-carrier-protein as well as the tetracenomycin M acyl-carrier-protein component of the tetracenomycin type II polyketide synthase | Streptomyces glaucescens | CoA + malonyl-[acyl-carrier protein] | - |
? | |
malonyl-CoA + acyl-carrier protein | characterization of acyl-carrier protein | Streptomyces glaucescens | CoA + malonyl-[acyl-carrier protein] | - |
? | |
additional information | the enzyme is responsible for charging the tetracenomycin M acyl-carrier-protein with malonate in vivo, a key step in the synthesis of the deca(polyketide) precursor of tetracenomycin C. This implies the existence of a functional connection between fatty acid and polyketide metabolism in this bacterium | Streptomyces glaucescens | ? | - |
? |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8 | - |
assay at | Streptomyces glaucescens |