General Stability | Organism |
---|---|
salt concentrations above 0.1 M inactivate | Escherichia coli |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
acetyl-CoA | competitive to malonyl-CoA | Escherichia coli | |
iodoacetamide | malonyl-CoA protects; pH-dependent | Escherichia coli | |
iodoacetate | - |
Escherichia coli | |
additional information | - |
Escherichia coli | |
p-chloromercuribenzoate | pH-independent | Escherichia coli | |
phenylmethanesulfonyl fluoride | malonyl-CoA protects | Escherichia coli |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
35000 | - |
1 * 35000, SDS-PAGE, alkylated: 1 * 35500, SDS-PAGE, native: 1 * 36500, SDS-PAGE | Escherichia coli |
35500 | - |
1 * 35000, SDS-PAGE, alkylated: 1 * 35500, SDS-PAGE, native: 1 * 36500, SDS-PAGE | Escherichia coli |
36500 | - |
1 * 35000, SDS-PAGE, alkylated: 1 * 35500, SDS-PAGE, native: 1 * 36500, SDS-PAGE | Escherichia coli |
36660 | - |
carboxymethylated enzyme: sedimentation equilibrium centrifugation | Escherichia coli |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Escherichia coli |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
malonyl-CoA + an [acyl-carrier protein] = CoA + a malonyl-[acyl-carrier protein] | mechanism, formation of a malonyl-enzyme intermediate | Escherichia coli |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
malonyl-CoA + acyl-carrier protein | acetyl-CoA cannot replace malonyl-CoA | Escherichia coli | CoA + malonyl-[acyl-carrier protein] | - |
? | |
malonyl-CoA + N-(N-acetyl-beta-alanyl)cysteamine | - |
Escherichia coli | CoA + N-(N-acetyl-beta-alanyl)-S-malonylcysteamine | - |
? | |
malonyl-CoA + N-acetylcysteamine | - |
Escherichia coli | CoA + N-acetyl-S-malonylcysteamine | - |
? | |
malonyl-CoA + pantetheine | - |
Escherichia coli | malonyl-pantetheine + CoA | - |
? |
Subunits | Comment | Organism |
---|---|---|
monomer | 1 * 35000, SDS-PAGE, alkylated: 1 * 35500, SDS-PAGE, native: 1 * 36500, SDS-PAGE | Escherichia coli |
More | vertebrates, yeast and Mycobacteria fatty acid synthetases contain all individual activities on one or two multifunctional polypeptide chains, plant, Escherichia coli and other prokaryotic fatty acid synthases are non-associated systems of individual enzymes | Escherichia coli |
Synonyms | Comment | Organism |
---|---|---|
More | in vertebrates, yeast and mycobacteria malonyl transferase activity is a domain of the multifunctional polypeptide chains of fatty acid synthase EC 2.3.1.85 and EC 2.3.1.86 | Escherichia coli |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
6.5 | 8.5 | - |
Escherichia coli |