BRENDA - Enzyme Database show
show all sequences of 2.3.1.37

Expression of murine 5-aminolevulinate synthase variants causes protoporphyrin IX accumulation and light-induced mammalian cell death

Fratz, E.J.; Hunter, G.A.; Ferreira, G.C.; PLoS ONE 9, e93078 (2014)

Data extracted from this reference:

Application
Application
Commentary
Organism
medicine
delivery of stable and highly active ALAS2 variants has the potential to expand and improve upon current photodynamic therapies regimes
Mus musculus
Cloned(Commentary)
Commentary
Organism
gene ALAS, recombinant expression in HeLa cells, stable expression of enzyme variants in K-562 cells
Mus musculus
Engineering
Amino acid exchange
Commentary
Organism
K313A
site-directed mutagenesis, inactive mutant
Mus musculus
additional information
generation of enzyme mutant with mutated mitochondrial presequences, at residues C11 C38, and C70, and a mutation in the active site loop Expression of the mutants in human cells causes significant cellular accumulation of protoporphyrin IX, particularly in the membrane. ALAS2 expression results in an increase in cell death in comparison to aminolevulinic acid treatment producing a similar amount of protoporphyrin IX. Supplementation of cell culture medium with glycine leads to increased protoporphyrin IX accumulation in Malas2-expressing HeLa cells
Mus musculus
R433K
site-directed mutagenesis, mALAS2 variant with a mutated presequence, the mutation results in an increase in activity to twice that of the wild-type enzyme, i.e. a 2fold increase in the kcat value and a 1.65 to 1.85fold enhancement in the specificity constants for glycine and succinyl-CoA over those of wild-type, mature mALAS2, 2.5fold increase in protoporphyrin IX accumulation in HeLa cells expressing the R433K precursor with a mutated presequence
Mus musculus
V423L/Y428R/P432E/R433I/G434N/E435Q/L437K
site-directed mutagenesis,
Mus musculus
Inhibitors
Inhibitors
Commentary
Organism
Structure
heme
feedback inhibition of mitochondrial import
Mus musculus
Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
mitochondrion
-
Mus musculus
5739
-
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
succinyl-CoA + glycine
Mus musculus
-
5-aminolevulinate + CoA + CO2
-
-
?
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Mus musculus
P08680
gene alas2
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
succinyl-CoA + glycine
-
737145
Mus musculus
5-aminolevulinate + CoA + CO2
-
-
-
?
Application (protein specific)
Application
Commentary
Organism
medicine
delivery of stable and highly active ALAS2 variants has the potential to expand and improve upon current photodynamic therapies regimes
Mus musculus
Cloned(Commentary) (protein specific)
Commentary
Organism
gene ALAS, recombinant expression in HeLa cells, stable expression of enzyme variants in K-562 cells
Mus musculus
Engineering (protein specific)
Amino acid exchange
Commentary
Organism
K313A
site-directed mutagenesis, inactive mutant
Mus musculus
additional information
generation of enzyme mutant with mutated mitochondrial presequences, at residues C11 C38, and C70, and a mutation in the active site loop Expression of the mutants in human cells causes significant cellular accumulation of protoporphyrin IX, particularly in the membrane. ALAS2 expression results in an increase in cell death in comparison to aminolevulinic acid treatment producing a similar amount of protoporphyrin IX. Supplementation of cell culture medium with glycine leads to increased protoporphyrin IX accumulation in Malas2-expressing HeLa cells
Mus musculus
R433K
site-directed mutagenesis, mALAS2 variant with a mutated presequence, the mutation results in an increase in activity to twice that of the wild-type enzyme, i.e. a 2fold increase in the kcat value and a 1.65 to 1.85fold enhancement in the specificity constants for glycine and succinyl-CoA over those of wild-type, mature mALAS2, 2.5fold increase in protoporphyrin IX accumulation in HeLa cells expressing the R433K precursor with a mutated presequence
Mus musculus
V423L/Y428R/P432E/R433I/G434N/E435Q/L437K
site-directed mutagenesis,
Mus musculus
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
heme
feedback inhibition of mitochondrial import
Mus musculus
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
mitochondrion
-
Mus musculus
5739
-
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
succinyl-CoA + glycine
Mus musculus
-
5-aminolevulinate + CoA + CO2
-
-
?
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
succinyl-CoA + glycine
-
737145
Mus musculus
5-aminolevulinate + CoA + CO2
-
-
-
?
Expression
Organism
Commentary
Expression
Mus musculus
the enzyme is negatively regulated by heme at the level of mitochondrial import
down
General Information
General Information
Commentary
Organism
malfunction
mutations of the murine ALAS2 active site loop result in increased production of protoporphyrin IX, the precursor for heme. Generation of protoporphyrin IX is a crucial component in the widely used photodynamic therapies of cancer and other dysplasias. ALAS2 variants that cause high levels of protoporphyrin IX accumulation provide a means of targeted, and potentially enhanced, photosensitization. ALAS2-induced protoporphyrin IX accumulation followed by light exposure combined with paclitaxel treatment causes cell death
Mus musculus
metabolism
5-aminolevulinate synthase catalyzes the first committed step of heme biosynthesis in animals
Mus musculus
General Information (protein specific)
General Information
Commentary
Organism
malfunction
mutations of the murine ALAS2 active site loop result in increased production of protoporphyrin IX, the precursor for heme. Generation of protoporphyrin IX is a crucial component in the widely used photodynamic therapies of cancer and other dysplasias. ALAS2 variants that cause high levels of protoporphyrin IX accumulation provide a means of targeted, and potentially enhanced, photosensitization. ALAS2-induced protoporphyrin IX accumulation followed by light exposure combined with paclitaxel treatment causes cell death
Mus musculus
metabolism
5-aminolevulinate synthase catalyzes the first committed step of heme biosynthesis in animals
Mus musculus
Expression (protein specific)
Organism
Commentary
Expression
Mus musculus
the enzyme is negatively regulated by heme at the level of mitochondrial import
down
Other publictions for EC 2.3.1.37
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
735604
Ogawa-Otomo
Aminolevulinate synthase 2 med ...
Xenopus laevis
Biochem. Biophys. Res. Commun.
456
476-481
2015
-
-
1
-
-
-
-
-
-
-
-
-
-
4
-
-
-
-
-
6
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
6
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
735684
Fratz
Human erythroid 5-aminolevulin ...
Homo sapiens
Biochemistry
54
5617-5631
2015
-
-
1
-
2
-
-
1
1
-
-
1
-
3
-
-
-
-
-
1
-
-
1
1
-
-
1
-
-
-
-
1
-
-
-
-
-
1
1
-
2
-
-
-
-
1
1
-
-
1
-
-
-
-
-
1
-
-
1
1
-
-
1
-
-
-
-
-
-
5
5
-
-
-
736116
Stojanovski
Murine erythroid 5-aminolevuli ...
Mus musculus
FEBS open bio
5
824-831
2015
-
-
1
-
1
-
-
5
-
-
-
1
-
4
-
-
1
1
-
-
-
-
2
1
1
-
-
2
1
-
-
1
-
-
-
-
-
1
1
-
1
-
-
-
-
5
-
-
-
1
-
-
-
1
-
-
-
-
2
1
1
-
-
2
1
-
-
-
-
2
2
-
2
2
736491
Stojanovski
Asn-150 of murine erythroid 5- ...
Mus musculus
J. Biol. Chem.
290
30750-30761
2015
-
-
1
-
6
-
-
12
-
-
-
1
-
3
-
-
1
1
-
-
-
-
2
-
1
-
-
6
1
-
-
1
-
-
-
-
-
1
1
-
6
-
-
-
-
12
-
-
-
1
-
-
-
1
-
-
-
-
2
-
1
-
-
6
1
-
-
-
-
2
2
-
12
12
735711
Stojanovski
Catalytically active alkaline ...
Mus musculus
Biochim. Biophys. Acta
1844
2145-2154
2014
-
-
-
-
-
-
-
1
-
-
-
1
-
2
-
-
-
-
-
-
-
-
1
-
1
-
1
-
1
2
1
1
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
1
-
-
-
-
-
-
-
-
1
-
1
-
1
-
1
2
1
-
-
1
1
-
-
-
736454
Stojanovski
Unstable reaction intermediate ...
Mus musculus
J. Biol. Chem.
289
22915-22925
2014
-
-
-
-
1
-
-
1
-
-
-
1
-
3
-
-
-
1
-
-
-
-
4
-
1
-
-
-
1
-
-
1
-
-
-
-
-
-
1
-
1
-
-
-
-
1
-
-
-
1
-
-
-
-
-
-
-
-
4
-
1
-
-
-
1
-
-
-
-
1
1
-
-
-
737145
Fratz
Expression of murine 5-aminole ...
Mus musculus
PLoS ONE
9
e93078
2014
-
1
1
-
4
-
1
-
1
-
-
1
-
5
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
4
-
-
1
-
-
1
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
1
2
2
1
-
-
736819
Bishop
Molecular expression and chara ...
Homo sapiens
Mol. Med.
19
18-25
2013
-
-
1
-
3
-
-
12
-
-
2
1
-
2
-
-
1
-
-
-
-
-
1
1
1
-
2
-
1
-
-
1
-
-
-
-
-
1
1
-
3
-
-
-
-
12
-
-
2
1
-
-
-
1
-
-
-
-
1
1
1
-
2
-
1
-
-
-
-
1
1
-
-
-
719402
Shaik
Sigma-Aminolevulinate synthase ...
Drosophila melanogaster
Eur. J. Cell Biol.
91
204-215
2012
-
-
-
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
-
1
-
-
-
1
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
1
1
-
-
-
719419
Kadirvel
The carboxyl-terminal region o ...
Homo sapiens
Exp. Hematol.
40
477-486.e1
2012
-
-
1
-
4
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
1
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
718696
Turbeville
Functional asymmetry for the a ...
Mus musculus
Arch. Biochem. Biophys.
511
107-117
2011
-
-
1
-
1
-
-
8
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
1
-
-
4
1
-
-
1
-
-
-
-
-
1
1
-
1
-
-
-
-
8
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
4
1
-
-
-
-
-
-
-
-
-
718890
Zhang
Hypoxic induction of human ery ...
Homo sapiens
Biochemistry
50
1194-1202
2011
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
2
-
-
720074
Kiatpapan
Production of 5-aminolevulinic ...
Acidipropionibacterium acidipropionici
J. Biosci. Bioeng.
111
425-428
2011
-
1
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
1
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
703095
Huang
Erythroid 5-aminolevulinate sy ...
Homo sapiens
Cell Biochem. Funct.
28
122-125
2010
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
703855
Okano
Indispensable function for emb ...
Mus musculus
Genes Cells
15
77-89
2010
-
-
-
-
-
-
-
-
-
-
-
-
-
4
-
-
-
-
-
9
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
9
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
704690
Lendrihas
Serine 254 enhances an induced ...
Mus musculus
J. Biol. Chem.
285
3351-3359
2010
-
-
-
-
2
-
-
6
-
-
-
-
-
6
-
-
-
-
-
1
-
-
1
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
6
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
3
-
-
-
-
-
-
-
-
6
6
719861
Lendrihas
Targeting the active site gate ...
Escherichia coli
J. Biol. Chem.
285
13704-13711
2010
-
-
-
-
9
-
-
16
-
-
-
-
-
3
-
-
-
-
-
-
-
-
1
-
1
-
-
8
1
-
-
1
-
-
-
-
-
-
1
-
9
-
-
-
-
16
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
8
1
-
-
-
-
-
-
-
-
-
691351
Lin
Characterization of 5-aminolev ...
Agrobacterium tumefaciens
Biores. Technol.
100
2293-2297
2009
-
1
1
-
-
-
1
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
701767
Liu
d-Glucose enhanced 5-aminolevu ...
Agrobacterium tumefaciens
Appl. Biochem. Biotechnol.
160
822-830
2009
-
1
1
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
703124
du Plessis
Functional analysis of the 5 r ...
Homo sapiens
Cell. Mol. Biol.
55
20-30
2009
-
-
-
-
1
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
703125
Buzaleh
Induction of hepatic aminolevu ...
Mus musculus
Cell. Mol. Biol.
55
38-44
2009
-
1
-
-
-
-
-
-
-
-
-
-
-
5
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
703635
Kaneko
Hypoxia induces erythroid-spec ...
Homo sapiens
FEBS J.
276
1370-1382
2009
-
1
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
705917
Dwyer
Down-regulation of aminolevuli ...
Homo sapiens
Neurosci. Lett.
460
180-184
2009
-
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
706627
Lendrihas
Arg-85 and Thr-430 in murine 5 ...
Mus musculus
Protein Sci.
18
1847-1859
2009
-
-
-
-
3
-
-
38
-
-
-
-
-
4
-
-
-
-
-
1
-
-
5
-
-
-
-
18
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
38
-
-
-
-
-
-
-
-
-
1
-
-
5
-
-
-
-
18
-
-
-
-
-
-
-
-
33
33
685795
Han
Sodium butyrate activates eryt ...
Homo sapiens
Blood Cells Mol. Dis.
41
148-153
2008
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
705080
Choi
Extracellular 5-aminolevulinic ...
Rhodopseudomonas palustris
J. Microbiol. Biotechnol.
18
1136-1140
2008
-
1
1
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
706104
Jung
-
Defence response produced duri ...
Bradyrhizobium japonicum
Photosynthetica
46
3-9
2008
-
1
1
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
677945
Tahara
Decrease of hepatic delta-amin ...
Rattus norvegicus, Rattus norvegicus Sprague-Dawley
Biochem. Biophys. Res. Commun.
353
1068-1073
2007
-
-
-
-
-
-
-
-
-
-
-
-
-
165
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
687586
Hunter
Transient kinetic studies supp ...
Mus musculus
J. Biol. Chem.
282
23025-23035
2007
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
688761
Martini
Induction of 5-aminolevulinate ...
Homo sapiens, Rattus norvegicus
Life Sci.
81
19-25
2007
-
-
-
-
-
-
-
-
-
-
-
-
-
4
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
677263
Wang
-
Expression of 5-aminolevulinic ...
Escherichia coli
World J. Microbiol. Biotechnol.
22
461-468
2006
-
1
1
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
1
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
660994
Dailey
Examination of mitochondrial p ...
Homo sapiens
Biochem. J.
386
381-386
2005
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
663337
Zhang
Conversion of 5-aminolevulinat ...
Mus musculus
Protein Sci.
14
1190-1200
2005
-
-
-
-
1
-
-
8
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
8
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
671583
Guberman
Repression of 5-aminolevulinat ...
Homo sapiens
Arch. Biochem. Biophys.
436
285-296
2005
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
671812
Abu-Farha
Erythroid-specific 5-aminolevu ...
Homo sapiens
Biochem. Cell Biol.
83
620-630
2005
-
-
1
-
-
-
-
-
-
-
-
1
-
1
1
2
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
1
-
1
2
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
672997
Rodriguez
Heme oxygenase, aminolevulinat ...
Mus musculus
Cell. Mol. Biol.
51
487-494
2005
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
673319
Astner
Crystal structure of 5-aminole ...
Rhodobacter capsulatus
EMBO J.
24
3166-3177
2005
-
-
1
1
-
-
-
-
-
-
-
-
-
5
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
661787
Choi
Cloning, expression, and chara ...
Rhodopseudomonas palustris, Rhodopseudomonas palustris KUGB306
FEMS Microbiol. Lett.
236
175-181
2004
-
-
1
-
-
-
7
2
-
-
-
-
-
2
-
-
-
1
-
-
1
-
2
-
1
-
1
-
1
-
1
1
-
-
-
-
-
1
1
-
-
-
-
7
-
2
-
-
-
-
-
-
-
-
-
-
1
-
2
-
1
-
1
-
1
-
1
-
-
-
-
-
-
-
661895
Cox
The major splice variant of hu ...
Homo sapiens
Int. J. Biochem. Cell Biol.
36
281-295
2004
-
-
-
-
-
-
-
-
1
-
-
-
-
2
-
1
-
-
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
486846
Hofer
Hypoxic up-regulation of eryth ...
Mus musculus
Blood
101
348-350
2003
2
-
1
-
1
-
-
-
-
-
-
1
-
2
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
1
-
-
-
2
-
1
1
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
660773
Xie
Optimization of recombinant am ...
Rhodobacter sphaeroides
Appl. Microbiol. Biotechnol.
63
267-273
2003
-
1
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
661232
Shoolingin-Jordan
5-Aminolevulinic acid synthase ...
Homo sapiens, Rhodobacter sphaeroides
Biochim. Biophys. Acta
1647
361-366
2003
-
1
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
662145
Cheltsov
Circular permutation of 5-amin ...
Mus musculus
J. Biol. Chem.
278
27945-27955
2003
-
-
-
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
486860
Varadharajan
Involvement of delta-aminolevu ...
Plasmodium falciparum
Biochem. J.
367
321-327
2002
-
1
1
-
-
-
3
2
1
-
2
1
-
1
-
-
-
-
-
1
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
-
-
3
-
2
1
-
2
1
-
-
-
-
-
1
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
486861
Zhang
Transient state kinetic invest ...
Mus musculus
J. Biol. Chem.
277
44660-44669
2002
-
-
-
-
-
-
-
-
-
-
-
2
-
3
-
-
-
1
-
-
-
-
3
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
486858
Kaliman
Regulation of delta-aminolevul ...
Rattus norvegicus
Biochemistry
64
699-704
1999
-
-
-
-
-
-
2
-
-
-
-
1
-
2
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
1
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
486859
Hunter
Lysine-313 of 5-aminolevulinat ...
Mus musculus
Biochemistry
38
3711-3718
1999
-
-
-
-
2
-
-
-
-
-
-
2
-
4
-
-
-
1
-
-
-
-
3
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
2
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
486855
Tan
The role of tyrosine 121 in co ...
Mus musculus
Protein Sci.
7
1208-1213
1998
-
-
1
-
2
-
-
6
-
-
1
-
-
5
-
-
1
1
-
-
-
-
1
-
-
-
-
3
1
1
-
1
-
-
-
-
-
1
1
-
2
-
-
-
-
6
-
-
1
-
-
-
-
1
-
-
-
-
1
-
-
-
-
3
1
1
-
-
-
-
-
-
-
-
486856
Gong
Aspartate-279 in aminolevulina ...
Mus musculus
Biochemistry
37
3509-3517
1998
-
-
1
-
2
-
-
4
-
-
-
-
-
5
-
-
1
1
-
-
-
-
1
-
-
-
-
2
-
-
-
2
-
-
-
-
-
1
2
-
2
-
-
-
-
4
-
-
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
486857
Tan
Role of arginine 439 in substr ...
Mus musculus
Biochemistry
37
1478-1484
1998
-
-
1
-
4
-
-
8
-
-
-
-
-
4
-
-
-
1
-
-
-
-
1
-
-
-
-
4
-
-
-
1
-
-
-
-
-
1
1
-
4
-
-
-
-
8
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
486853
Dailey
Expression and purification of ...
Gallus gallus, Homo sapiens, Mus musculus, Rattus norvegicus
Methods Enzymol.
281
336-340
1997
-
-
-
-
-
4
4
2
-
4
2
5
-
7
-
-
1
-
-
4
-
-
9
3
-
-
-
1
-
-
-
4
-
-
-
-
-
-
4
-
-
4
-
4
-
2
-
4
2
5
-
-
-
1
-
4
-
-
9
3
-
-
-
1
-
-
-
-
-
-
-
-
-
-
486854
Zavgorodnyaya
Yeast 5-aminolevulinate syntha ...
Saccharomyces cerevisiae
Plant J.
12
169-178
1997
-
1
1
-
1
-
-
-
-
-
-
1
-
5
-
-
-
-
-
-
1
-
2
-
-
-
-
-
-
-
-
1
-
-
-
-
1
1
1
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
486851
Gong
Mutations at a glycine loop in ...
Mus musculus, Rattus norvegicus
Biochemistry
35
14109-14117
1996
-
-
1
-
4
-
-
10
-
-
-
-
-
5
-
-
1
1
-
-
-
-
2
-
-
-
2
5
-
-
-
2
-
-
-
-
-
1
2
-
4
-
-
-
-
10
-
-
-
-
-
-
-
1
-
-
-
-
2
-
-
-
2
5
-
-
-
-
-
-
-
-
-
-
486852
Tan
Active site of 5-aminolevulina ...
Mus musculus, Saccharomyces cerevisiae
Biochemistry
35
8934-8941
1996
-
-
1
-
5
-
-
4
-
-
4
2
-
8
-
-
1
2
-
-
-
-
4
4
-
-
-
-
-
-
-
2
-
-
-
-
-
1
2
-
5
-
-
-
-
4
-
-
4
2
-
-
-
1
-
-
-
-
4
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
486849
Ferreira
Aminolevulinate synthase: lysi ...
Mus musculus
Protein Sci.
4
1001-1006
1995
-
-
1
-
3
-
-
-
-
-
-
-
-
4
-
-
1
1
-
-
-
-
1
-
-
-
-
-
1
-
-
1
-
-
-
-
-
1
1
-
3
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
486850
Ferreira
5-Aminolevulinate synthase and ...
Agrobacterium tumefaciens, Aspergillus nidulans, Bradyrhizobium japonicum, Euglena gracilis, Gallus gallus, Homo sapiens, Mus musculus, Paracoccus denitrificans, Rattus norvegicus, Rhodobacter capsulatus, Rhodobacter sphaeroides, Saccharomyces cerevisiae, Sinorhizobium meliloti
J. Bioenerg. Biomembr.
27
151-159
1995
2
-
9
-
-
2
7
-
4
-
11
6
-
17
-
-
-
8
-
10
-
-
14
-
-
-
-
-
-
-
-
13
-
-
-
2
-
9
13
-
-
2
-
7
-
-
4
-
11
6
-
-
-
-
-
10
-
-
14
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
486824
Ferreira
Expression of mammalian 5-amin ...
Mus musculus
J. Biol. Chem.
268
584-590
1993
-
-
1
-
-
-
-
2
-
-
1
1
-
4
-
-
1
-
-
-
1
-
2
1
-
-
-
1
-
-
-
1
-
-
-
-
-
1
1
-
-
-
-
-
-
2
-
-
1
1
-
-
-
1
-
-
1
-
2
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
486847
Lake-Bullock
Biphasic ordered induction of ...
Mus musculus
Mol. Cell. Biol.
13
7122-7132
1993
3
-
1
-
1
-
-
-
-
-
-
2
-
2
-
-
-
-
-
2
-
-
3
-
-
-
-
-
-
-
-
1
-
-
-
3
-
1
1
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
2
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
486848
Munakata
Purification and structure of ...
Rattus norvegicus
J. Biochem.
114
103-111
1993
1
-
1
-
-
-
1
2
-
-
3
-
-
2
-
-
1
-
-
1
1
-
1
1
1
-
-
-
1
-
-
1
-
-
-
1
-
1
1
-
-
-
-
1
-
2
-
-
3
-
-
-
-
1
-
1
1
-
1
1
1
-
-
-
1
-
-
-
-
-
-
-
-
-
486808
Bishop
Human delta-aminolevulinate sy ...
Homo sapiens
Genomics
7
207-214
1990
-
-
-
-
-
-
-
-
1
-
-
1
-
2
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
486814
Ades
Properties of chicken erythroc ...
Gallus gallus
Int. J. Biochem.
20
965-969
1988
-
-
-
-
-
-
1
2
1
-
2
-
-
3
-
-
1
-
-
4
-
-
1
1
-
-
-
-
1
-
-
1
-
-
-
-
-
-
1
-
-
-
-
1
-
2
1
-
2
-
-
-
-
1
-
4
-
-
1
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
486815
Viale
-
Extraction and characterizatio ...
Rhodopseudomonas palustris
Comp. Biochem. Physiol. B
87
607-613
1987
1
-
-
-
-
-
2
1
-
-
1
-
-
1
-
-
-
-
-
1
-
2
2
1
1
-
-
-
1
-
-
1
-
-
-
1
-
-
1
-
-
-
-
2
-
1
-
-
1
-
-
-
-
-
-
1
-
2
2
1
1
-
-
-
1
-
-
-
-
-
-
-
-
-
486816
Fernandez
Trout (Salmo gairdenri R.) liv ...
Oncorhynchus mykiss
Comp. Biochem. Physiol. B
86
245-249
1987
-
-
-
-
-
-
-
-
2
-
2
-
-
2
-
-
-
-
-
2
-
-
1
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
2
-
2
-
-
-
-
-
-
2
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
486818
Borthwick
Purification of hepatic mitoch ...
Gallus gallus, Rattus norvegicus
Methods Enzymol.
123
395-401
1986
-
-
-
-
-
-
-
-
6
-
-
2
-
2
-
-
2
-
-
4
2
4
4
-
2
-
-
-
-
-
-
2
-
-
-
-
-
-
2
-
-
-
-
-
-
-
6
-
-
2
-
-
-
2
-
4
2
4
4
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
486819
Jordan
Purification of 5-aminolevulin ...
Rhodobacter sphaeroides
Methods Enzymol.
123
435-443
1986
-
-
-
-
-
-
5
-
-
-
2
-
-
1
-
-
1
1
-
-
1
-
5
1
1
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
5
-
-
-
-
2
-
-
-
-
1
-
-
1
-
5
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
486839
Sato
-
Purification and some properti ...
Rhodobacter sphaeroides, Serratia plymuthica
Agric. Biol. Chem.
49
3415-3421
1985
2
-
-
-
-
4
2
4
-
-
2
-
-
2
-
-
2
-
-
-
2
1
2
-
2
-
-
-
2
-
-
2
-
-
-
2
-
-
2
-
-
4
-
2
-
4
-
-
2
-
-
-
-
2
-
-
2
1
2
-
2
-
-
-
2
-
-
-
-
-
-
-
-
-
486840
Sato
-
Occurence and some properties ...
Serratia plymuthica
Agric. Biol. Chem.
49
3423-3428
1985
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
1
-
-
-
1
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
1
-
-
-
-
1
-
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
486835
Volland
Isolation and properties of 5- ...
Saccharomyces cerevisiae
Eur. J. Biochem.
142
551-557
1984
-
-
-
-
-
-
4
2
2
-
2
-
-
2
-
-
1
-
-
-
1
-
1
1
1
-
-
-
1
1
-
1
-
-
-
-
-
-
1
-
-
-
-
4
-
2
2
-
2
-
-
-
-
1
-
-
1
-
1
1
1
-
-
-
1
1
-
-
-
-
-
-
-
-
486823
Scotto
The characterization and submi ...
Rattus norvegicus
J. Biol. Chem.
258
81-90
1983
-
-
-
-
-
-
-
-
3
-
-
-
-
2
-
-
-
-
-
2
-
-
1
-
-
-
1
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
2
-
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
486836
Borthwick
Purification of 5-aminolaevuli ...
Gallus gallus
Eur. J. Biochem.
129
615-620
1983
-
-
-
-
-
-
-
-
1
-
1
-
-
1
-
-
1
-
-
2
1
-
1
1
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
1
-
1
-
-
-
-
1
-
2
1
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
486838
Srivastava
Purification of rat liver mito ...
Rattus norvegicus
Biochem. Biophys. Res. Commun.
109
305-312
1982
-
-
-
-
-
-
-
-
1
-
2
-
-
1
-
-
1
-
-
1
1
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
1
-
2
-
-
-
-
1
-
1
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
486817
Kreit
Control of 5-aminolevulinic ac ...
Rhodospirillum rubrum
Biochimie
63
439-444
1981
1
-
-
-
-
-
4
-
-
-
1
-
-
4
-
-
1
-
-
-
-
-
1
-
-
-
-
-
1
-
-
1
-
-
-
1
-
-
1
-
-
-
-
4
-
-
-
-
1
-
-
-
-
1
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
486822
Simpson
Purification of a specific act ...
Rattus norvegicus
J. Biol. Chem.
255
1630-1634
1980
2
-
-
-
-
-
-
-
2
-
4
-
-
2
-
-
-
-
-
2
-
-
1
1
-
-
-
-
1
-
-
1
-
-
-
2
-
-
1
-
-
-
-
-
-
-
2
-
4
-
-
-
-
-
-
2
-
-
1
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
486834
Nakakuki
Purification and some properti ...
Rattus norvegicus
J. Biol. Chem.
255
1738-1745
1980
-
-
-
-
-
-
-
3
3
-
2
-
-
2
-
-
1
-
-
2
1
-
1
1
1
-
-
-
1
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
3
3
-
2
-
-
-
-
1
-
2
1
-
1
1
1
-
-
-
1
-
-
-
-
-
-
-
-
-
486825
Davies
Control of 5-aminolaevulinate ...
Rhodobacter sphaeroides
Biochem. J.
177
649-659
1979
-
-
-
-
-
-
-
-
-
-
3
-
-
1
-
-
1
-
-
-
1
-
1
1
1
-
-
-
1
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
3
-
-
-
-
1
-
-
1
-
1
1
1
-
-
-
1
-
-
-
-
-
-
-
-
-
486826
Davies
Control of 5-aminolaevulinate ...
Rhodobacter sphaeroides
Biochem. J.
177
661-671
1979
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
1
-
-
1
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
486833
Paterniti
delta-Aminolevulinic acid synt ...
Rattus norvegicus
J. Biol. Chem.
254
6112-6118
1979
-
-
-
-
-
-
3
1
2
2
2
-
-
2
-
-
1
-
-
2
1
1
1
1
-
-
-
-
1
-
-
1
-
-
-
-
-
-
1
-
-
-
-
3
-
1
2
2
2
-
-
-
-
1
-
2
1
1
1
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
486837
Ohashi
Purification and some properti ...
Rattus norvegicus
J. Biochem.
85
239-247
1979
-
-
-
-
-
-
2
2
2
2
2
-
-
2
-
-
1
-
-
2
1
-
1
1
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
2
-
2
2
2
2
-
-
-
-
1
-
2
1
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
486821
Nandi
Studies on delta-aminolevulini ...
Rhodobacter sphaeroides
J. Biol. Chem.
253
8872-8877
1978
-
-
-
-
-
-
4
-
-
-
-
-
-
2
-
-
-
1
-
-
-
-
1
-
-
-
-
-
-
-
-
1
2
-
-
-
-
-
1
-
-
-
-
4
2
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
486827
Ibrahim
Hemin feedback inhibition at r ...
Oryctolagus cuniculus
Biochem. Biophys. Res. Commun.
80
722-728
1978
-
-
-
-
-
-
1
-
2
-
-
-
-
1
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
486832
Whiting
delta-Aminolevulinic acid synt ...
Gallus gallus
J. Biol. Chem.
251
1340-1346
1976
-
-
-
-
-
-
4
-
-
4
2
-
-
1
-
-
1
-
-
2
1
2
1
1
-
-
-
-
-
-
-
1
1
-
-
-
-
-
1
-
-
-
-
4
1
-
-
4
2
-
-
-
-
1
-
2
1
2
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
486831
Clement-Metral
5-Aminolevulinic-acid syntheta ...
Rhodobacter sphaeroides, Rhodobacter sphaeroides Y
Eur. J. Biochem.
59
73-77
1975
-
-
-
-
-
-
2
-
-
-
1
-
-
6
-
-
1
-
-
-
1
-
2
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
2
-
-
-
-
1
-
-
-
-
1
-
-
1
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
486830
Hayasaka
Control of delta-aminolevulina ...
Rhodobacter sphaeroides
J. Biochem.
76
157-168
1974
2
-
-
-
-
-
2
-
-
-
-
-
-
2
-
-
1
-
-
-
1
-
1
-
-
-
-
-
-
-
-
1
-
-
-
2
-
-
1
-
-
-
-
2
-
-
-
-
-
-
-
-
-
1
-
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
486841
Murthy
Solubilization and partial pur ...
Rattus norvegicus
Biochim. Biophys. Acta
350
240-246
1974
1
-
-
-
-
-
3
-
2
-
-
-
-
2
-
-
1
-
-
4
1
-
1
-
-
-
-
-
-
-
-
1
-
-
-
1
-
-
1
-
-
-
-
3
-
-
2
-
-
-
-
-
-
1
-
4
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
486809
Ramaswamy
delta-Aminolevulinic acid synt ...
Solanum tuberosum
Biochim. Biophys. Acta
293
269-277
1973
2
-
-
-
-
-
4
-
-
1
-
1
-
1
-
-
-
-
-
1
2
1
2
-
1
-
1
-
1
-
-
1
-
-
-
2
-
-
1
-
-
-
-
4
-
-
-
1
-
1
-
-
-
-
-
1
2
1
2
-
1
-
1
-
1
-
-
-
-
-
-
-
-
-
486810
Tait
Aminolaevulinate synthetase of ...
Paracoccus denitrificans
Biochem. J.
131
389-403
1973
-
-
-
-
-
-
4
3
-
-
1
-
-
1
-
-
1
-
-
1
2
-
1
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
1
-
-
-
-
4
-
3
-
-
1
-
-
-
-
1
-
1
2
-
1
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
486844
Fanica-Gaignier
5-Aminolevulinic-acid syntheta ...
Rhodobacter sphaeroides, Rhodobacter sphaeroides Y
Eur. J. Biochem.
40
13-18
1973
-
-
-
-
-
-
-
-
-
-
2
-
-
6
-
-
1
-
-
-
2
1
2
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
2
-
-
-
-
1
-
-
2
1
2
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
486845
Fanica-Gaignier
5-Aminolevulinic-acid syntheta ...
Rhodobacter sphaeroides, Rhodobacter sphaeroides Y
Eur. J. Biochem.
40
19-24
1973
-
-
-
-
-
-
4
1
-
-
-
-
-
6
-
-
-
1
-
-
-
-
2
-
-
-
-
-
-
-
-
1
3
-
-
-
-
-
1
-
-
-
-
4
3
1
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
486812
Scholnick
Souble delta-aminolevulinic ac ...
Rattus norvegicus
J. Biol. Chem.
247
4126-4131
1972
1
-
-
-
-
1
-
4
1
1
2
1
-
1
-
-
1
-
-
1
1
-
3
-
-
-
-
-
2
-
1
1
-
-
-
1
-
-
1
-
-
1
-
-
-
4
1
1
2
1
-
-
-
1
-
1
1
-
3
-
-
-
-
-
2
-
1
-
-
-
-
-
-
-
486813
Scholnick
Soluble delta-aminolevulinic a ...
Rattus norvegicus
J. Biol. Chem.
247
4132-4137
1972
-
-
-
-
-
-
14
-
1
-
-
-
-
1
-
-
-
1
-
1
-
-
1
-
-
-
-
-
-
-
-
1
1
-
-
-
-
-
1
-
-
-
-
14
1
-
1
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
486820
Jordan
-
delta-Aminolevulinic acid synt ...
Cavia porcellus, Gallus gallus, Homo sapiens, no activity in Chromatium sp., Novispirillum itersonii, Oryctolagus cuniculus, Propionibacterium freudenreichii subsp. shermanii, Rattus norvegicus, Rhodobacter sphaeroides, Rhodospirillum rubrum, Saccharomyces cerevisiae, Spinacia oleracea
The Enzymes, 3rd Ed. (Boyer, P. D. , ed. )
7
339-356
1972
3
-
-
-
-
-
110
9
13
-
5
21
-
12
-
-
3
10
-
10
8
-
62
-
-
-
2
-
-
-
-
11
-
-
-
3
-
-
11
-
-
-
-
110
-
9
13
-
5
21
-
-
-
3
-
10
8
-
62
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
486828
Porra
The nature of the inhibition o ...
Rhodobacter sphaeroides
Arch. Biochem. Biophys.
148
37-43
1972
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
486842
Yubisui
delta-Aminolevulinic acid synt ...
Rhodobacter sphaeroides
Arch. Biochem. Biophys.
150
77-85
1972
1
-
-
-
-
1
12
-
-
-
1
-
-
1
-
-
1
-
-
-
1
1
1
-
-
-
-
-
1
-
-
1
-
-
-
1
-
-
1
-
-
1
-
12
-
-
-
-
1
-
-
-
-
1
-
-
1
1
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
486843
Whiting
Purification and properties of ...
Cavia porcellus, Rattus norvegicus
J. Biol. Chem.
247
6818-6826
1972
-
-
-
-
-
-
2
3
5
-
2
-
-
2
-
-
2
-
-
2
-
2
2
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
2
-
-
-
-
2
-
3
5
-
2
-
-
-
-
2
-
2
-
2
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
486811
Warnick
Regulation of prophyrin biosyn ...
Rhodobacter sphaeroides
J. Biol. Chem.
246
6880-6885
1971
1
-
-
-
-
1
3
-
-
1
1
-
-
1
-
-
1
-
-
-
1
2
2
2
-
-
1
-
1
-
-
1
-
-
-
1
-
-
1
-
-
1
-
3
-
-
-
1
1
-
-
-
-
1
-
-
1
2
2
2
-
-
1
-
1
-
-
-
-
-
-
-
-
-
486829
Tuboi
Control of delta-aminolevulina ...
Rhodobacter sphaeroides
Arch. Biochem. Biophys.
146
282-290
1971
-
-
-
-
-
-
-
-
-
-
2
-
-
1
-
-
1
-
-
-
1
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
2
-
-
-
-
1
-
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-