Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
erythroid cell | erythroid induction cultures of CD34+ hematopoietic stem/progenitor cells | Homo sapiens | - |
K-562 cell | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
ALAS2 | - |
Homo sapiens |
sigma-aminolevulinate synthase | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | HIF1R knockdown by RNA interference decreased the level of ALAS2 expression. In silico analysis reveal three potential hypoxia-response elements (HREs) that are located 611, 621, and 741 bp downstream of the ALAS2 gene | down |
Homo sapiens | under hypoxic conditions, significantly increased ALAS2 mRNA and protein levels are detected in K562 cells and erythroid induction cultures of CD34+ hematopoietic stem/progenitor cells | up |