BRENDA - Enzyme Database show
show all sequences of 2.3.1.37

Arg-85 and Thr-430 in murine 5-aminolevulinate synthase coordinate acyl-CoA-binding and contribute to substrate specificity

Lendrihas, T.; Zhang, J.; Hunter, G.A.; Ferreira, G.C.; Protein Sci. 18, 1847-1859 (2009)

Data extracted from this reference:

Engineering
Amino acid exchange
Commentary
Organism
R85K
catalytic efficiency similar to wild-type
Mus musculus
R85L
68fold increase in catalytic efficincy with substrate octanoyl-CoA
Mus musculus
R85L/T430V
strong decrease in catalytic efficiency
Mus musculus
KM Value [mM]
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.00054
-
butanoyl-CoA
mutant R85L/T430V, pH 7.5, 30°C
Mus musculus
0.0018
-
octanoyl-CoA
mutant R85L, pH 7.5, 30°C
Mus musculus
0.0027
-
butanoyl-CoA
mutant R85K, pH 7.5, 30°C
Mus musculus
0.0029
-
succinyl-CoA
wild-type, pH 7.5, 30°C
Mus musculus
0.0034
-
octanoyl-CoA
wild-type, pH 7.5, 30°C
Mus musculus
0.0055
-
2-hydroxybutanoyl-CoA
mutant R85K, pH 7.5, 30°C
Mus musculus
0.0061
-
2-hydroxybutanoyl-CoA
mutant R85L, pH 7.5, 30°C
Mus musculus
0.0061
-
butanoyl-CoA
wild-type, pH 7.5, 30°C
Mus musculus
0.0075
-
glutaryl-CoA
mutant R85K, pH 7.5, 30°C
Mus musculus
0.0093
-
butanoyl-CoA
mutant R85L, pH 7.5, 30°C
Mus musculus
0.0098
-
2-hydroxybutanoyl-CoA
wild-type, pH 7.5, 30°C
Mus musculus
0.0103
-
octanoyl-CoA
mutant R85K, pH 7.5, 30°C
Mus musculus
0.0124
-
succinyl-CoA
mutant R85K, pH 7.5, 30°C
Mus musculus
0.017
-
glutaryl-CoA
wild-type, pH 7.5, 30°C
Mus musculus
0.0171
-
glycine
wild-type, cosubstrate octanoyl-CoA, pH 7.5, 30°C
Mus musculus
0.0172
-
glycine
mutant R85K, cosubstrate butanoyl-CoA, pH 7.5, 30°C
Mus musculus
0.0172
-
octanoyl-CoA
mutant R85L/T430V, pH 7.5, 30°C
Mus musculus
0.0182
-
glycine
mutant R85K, cosubstrate 2-hydroxybutanoyl-CoA, pH 7.5, 30°C
Mus musculus
0.02
-
glycine
mutant R85K, cosubstrate succinyl-CoA, pH 7.5, 30°C
Mus musculus
0.0203
-
succinyl-CoA
mutant R85L, pH 7.5, 30°C
Mus musculus
0.0212
-
glycine
mutant R85K, cosubstrate glutaryl-CoA, pH 7.5, 30°C
Mus musculus
0.0221
-
glycine
wild-type, cosubstrate 2-hydroxybutanoyl-CoA, pH 7.5, 30°C
Mus musculus
0.0242
-
glycine
wild-type, cosubstrate succinyl-CoA, pH 7.5, 30°C
Mus musculus
0.0252
-
glycine
mutant R85K, cosubstrate octanoyl-CoA, pH 7.5, 30°C
Mus musculus
0.0284
-
glycine
wild-type, cosubstrate glutaryl-CoA, pH 7.5, 30°C
Mus musculus
0.0293
-
glycine
wild-type, cosubstrate butanoyl-CoA, pH 7.5, 30°C
Mus musculus
0.0301
-
glutaryl-CoA
mutant R85L, pH 7.5, 30°C
Mus musculus
0.0552
-
glycine
mutant R85L, cosubstrate octanoyl-CoA, pH 7.5, 30°C
Mus musculus
0.0591
-
glycine
mutant R85L, cosubstrate 2-hydroxybutanoyl-CoA, pH 7.5, 30°C
Mus musculus
0.0631
-
glycine
mutant R85L, cosubstrate succinyl-CoA, pH 7.5, 30°C
Mus musculus
0.0703
-
glycine
mutant R85L, cosubstrate butanoyl-CoA, pH 7.5, 30°C
Mus musculus
0.0706
-
glycine
mutant R85L, cosubstrate glutaryl-CoA, pH 7.5, 30°C
Mus musculus
0.0742
-
2-hydroxybutanoyl-CoA
mutant R85L/T430V, pH 7.5, 30°C
Mus musculus
0.0742
-
glycine
mutant cosubstrate octanoyl-CoA, R85L/T430V, pH 7.5, 30°C
Mus musculus
0.0882
-
glycine
mutant cosubstrate butanoyl-CoA, R85L/T430V, pH 7.5, 30°C
Mus musculus
0.0922
-
glycine
mutant cosubstrate 2-hydroxybutanoyl-CoA, R85L/T430V, pH 7.5, 30°C
Mus musculus
0.096
-
succinyl-CoA
mutant R85L/T430V, pH 7.5, 30°C
Mus musculus
0.0984
-
glycine
mutant cosubstrate succinyl-CoA, R85L/T430V, pH 7.5, 30°C
Mus musculus
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Mus musculus
-
-
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
erythrocyte
-
Mus musculus
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2-hydroxybutanoyl-CoA + glycine
-
706627
Mus musculus
? + CoA + CO2
-
-
-
?
butanoyl-CoA + glycine
-
706627
Mus musculus
? + CoA + CO2
-
-
-
?
glutaryl-CoA + glycine
-
706627
Mus musculus
? + CoA + CO2
-
-
-
?
octanoyl-CoA + glycine
-
706627
Mus musculus
? + CoA + CO2
-
-
-
?
succinyl-CoA + glycine
-
706627
Mus musculus
5-aminolevulinate + CoA + CO2
-
-
-
?
Turnover Number [1/s]
Turnover Number Minimum [1/s]
Turnover Number Maximum [1/s]
Substrate
Commentary
Organism
Structure
0.00002
-
octanoyl-CoA
mutant R85L/T430V, pH 7.5, 30°C
Mus musculus
0.001
-
butanoyl-CoA
mutant R85L/T430V, pH 7.5, 30°C
Mus musculus
0.002
-
succinyl-CoA
mutant R85L/T430V, pH 7.5, 30°C
Mus musculus
0.01
-
2-hydroxybutanoyl-CoA
mutant R85L, pH 7.5, 30°C
Mus musculus
0.016
-
succinyl-CoA
mutant R85L, pH 7.5, 30°C
Mus musculus
0.03
-
octanoyl-CoA
mutant R85L, pH 7.5, 30°C
Mus musculus
0.0335
-
butanoyl-CoA
mutant R85L, pH 7.5, 30°C
Mus musculus
0.037
-
glutaryl-CoA
mutant R85L, pH 7.5, 30°C
Mus musculus
0.047
-
2-hydroxybutanoyl-CoA
mutant R85K, pH 7.5, 30°C
Mus musculus
0.05
-
glutaryl-CoA
mutant R85K, pH 7.5, 30°C
Mus musculus
0.067
-
2-hydroxybutanoyl-CoA
wild-type, pH 7.5, 30°C
Mus musculus
0.105
-
butanoyl-CoA
wild-type, pH 7.5, 30°C
Mus musculus
0.107
-
succinyl-CoA
mutant R85K, pH 7.5, 30°C
Mus musculus
0.117
-
glutaryl-CoA
wild-type, pH 7.5, 30°C
Mus musculus
0.167
-
succinyl-CoA
wild-type, pH 7.5, 30°C
Mus musculus
0.17
-
butanoyl-CoA
mutant R85K, pH 7.5, 30°C
Mus musculus
0.172
-
octanoyl-CoA
mutant R85K, pH 7.5, 30°C
Mus musculus
0.34
-
octanoyl-CoA
wild-type, pH 7.5, 30°C
Mus musculus
Engineering (protein specific)
Amino acid exchange
Commentary
Organism
R85K
catalytic efficiency similar to wild-type
Mus musculus
R85L
68fold increase in catalytic efficincy with substrate octanoyl-CoA
Mus musculus
R85L/T430V
strong decrease in catalytic efficiency
Mus musculus
KM Value [mM] (protein specific)
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.00054
-
butanoyl-CoA
mutant R85L/T430V, pH 7.5, 30°C
Mus musculus
0.0018
-
octanoyl-CoA
mutant R85L, pH 7.5, 30°C
Mus musculus
0.0027
-
butanoyl-CoA
mutant R85K, pH 7.5, 30°C
Mus musculus
0.0029
-
succinyl-CoA
wild-type, pH 7.5, 30°C
Mus musculus
0.0034
-
octanoyl-CoA
wild-type, pH 7.5, 30°C
Mus musculus
0.0055
-
2-hydroxybutanoyl-CoA
mutant R85K, pH 7.5, 30°C
Mus musculus
0.0061
-
2-hydroxybutanoyl-CoA
mutant R85L, pH 7.5, 30°C
Mus musculus
0.0061
-
butanoyl-CoA
wild-type, pH 7.5, 30°C
Mus musculus
0.0075
-
glutaryl-CoA
mutant R85K, pH 7.5, 30°C
Mus musculus
0.0093
-
butanoyl-CoA
mutant R85L, pH 7.5, 30°C
Mus musculus
0.0098
-
2-hydroxybutanoyl-CoA
wild-type, pH 7.5, 30°C
Mus musculus
0.0103
-
octanoyl-CoA
mutant R85K, pH 7.5, 30°C
Mus musculus
0.0124
-
succinyl-CoA
mutant R85K, pH 7.5, 30°C
Mus musculus
0.017
-
glutaryl-CoA
wild-type, pH 7.5, 30°C
Mus musculus
0.0171
-
glycine
wild-type, cosubstrate octanoyl-CoA, pH 7.5, 30°C
Mus musculus
0.0172
-
glycine
mutant R85K, cosubstrate butanoyl-CoA, pH 7.5, 30°C
Mus musculus
0.0172
-
octanoyl-CoA
mutant R85L/T430V, pH 7.5, 30°C
Mus musculus
0.0182
-
glycine
mutant R85K, cosubstrate 2-hydroxybutanoyl-CoA, pH 7.5, 30°C
Mus musculus
0.02
-
glycine
mutant R85K, cosubstrate succinyl-CoA, pH 7.5, 30°C
Mus musculus
0.0203
-
succinyl-CoA
mutant R85L, pH 7.5, 30°C
Mus musculus
0.0212
-
glycine
mutant R85K, cosubstrate glutaryl-CoA, pH 7.5, 30°C
Mus musculus
0.0221
-
glycine
wild-type, cosubstrate 2-hydroxybutanoyl-CoA, pH 7.5, 30°C
Mus musculus
0.0242
-
glycine
wild-type, cosubstrate succinyl-CoA, pH 7.5, 30°C
Mus musculus
0.0252
-
glycine
mutant R85K, cosubstrate octanoyl-CoA, pH 7.5, 30°C
Mus musculus
0.0284
-
glycine
wild-type, cosubstrate glutaryl-CoA, pH 7.5, 30°C
Mus musculus
0.0293
-
glycine
wild-type, cosubstrate butanoyl-CoA, pH 7.5, 30°C
Mus musculus
0.0301
-
glutaryl-CoA
mutant R85L, pH 7.5, 30°C
Mus musculus
0.0552
-
glycine
mutant R85L, cosubstrate octanoyl-CoA, pH 7.5, 30°C
Mus musculus
0.0591
-
glycine
mutant R85L, cosubstrate 2-hydroxybutanoyl-CoA, pH 7.5, 30°C
Mus musculus
0.0631
-
glycine
mutant R85L, cosubstrate succinyl-CoA, pH 7.5, 30°C
Mus musculus
0.0703
-
glycine
mutant R85L, cosubstrate butanoyl-CoA, pH 7.5, 30°C
Mus musculus
0.0706
-
glycine
mutant R85L, cosubstrate glutaryl-CoA, pH 7.5, 30°C
Mus musculus
0.0742
-
2-hydroxybutanoyl-CoA
mutant R85L/T430V, pH 7.5, 30°C
Mus musculus
0.0742
-
glycine
mutant cosubstrate octanoyl-CoA, R85L/T430V, pH 7.5, 30°C
Mus musculus
0.0882
-
glycine
mutant cosubstrate butanoyl-CoA, R85L/T430V, pH 7.5, 30°C
Mus musculus
0.0922
-
glycine
mutant cosubstrate 2-hydroxybutanoyl-CoA, R85L/T430V, pH 7.5, 30°C
Mus musculus
0.096
-
succinyl-CoA
mutant R85L/T430V, pH 7.5, 30°C
Mus musculus
0.0984
-
glycine
mutant cosubstrate succinyl-CoA, R85L/T430V, pH 7.5, 30°C
Mus musculus
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
erythrocyte
-
Mus musculus
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2-hydroxybutanoyl-CoA + glycine
-
706627
Mus musculus
? + CoA + CO2
-
-
-
?
butanoyl-CoA + glycine
-
706627
Mus musculus
? + CoA + CO2
-
-
-
?
glutaryl-CoA + glycine
-
706627
Mus musculus
? + CoA + CO2
-
-
-
?
octanoyl-CoA + glycine
-
706627
Mus musculus
? + CoA + CO2
-
-
-
?
succinyl-CoA + glycine
-
706627
Mus musculus
5-aminolevulinate + CoA + CO2
-
-
-
?
Turnover Number [1/s] (protein specific)
Turnover Number Minimum [1/s]
Turnover Number Maximum [1/s]
Substrate
Commentary
Organism
Structure
0.00002
-
octanoyl-CoA
mutant R85L/T430V, pH 7.5, 30°C
Mus musculus
0.001
-
butanoyl-CoA
mutant R85L/T430V, pH 7.5, 30°C
Mus musculus
0.002
-
succinyl-CoA
mutant R85L/T430V, pH 7.5, 30°C
Mus musculus
0.01
-
2-hydroxybutanoyl-CoA
mutant R85L, pH 7.5, 30°C
Mus musculus
0.016
-
succinyl-CoA
mutant R85L, pH 7.5, 30°C
Mus musculus
0.03
-
octanoyl-CoA
mutant R85L, pH 7.5, 30°C
Mus musculus
0.0335
-
butanoyl-CoA
mutant R85L, pH 7.5, 30°C
Mus musculus
0.037
-
glutaryl-CoA
mutant R85L, pH 7.5, 30°C
Mus musculus
0.047
-
2-hydroxybutanoyl-CoA
mutant R85K, pH 7.5, 30°C
Mus musculus
0.05
-
glutaryl-CoA
mutant R85K, pH 7.5, 30°C
Mus musculus
0.067
-
2-hydroxybutanoyl-CoA
wild-type, pH 7.5, 30°C
Mus musculus
0.105
-
butanoyl-CoA
wild-type, pH 7.5, 30°C
Mus musculus
0.107
-
succinyl-CoA
mutant R85K, pH 7.5, 30°C
Mus musculus
0.117
-
glutaryl-CoA
wild-type, pH 7.5, 30°C
Mus musculus
0.167
-
succinyl-CoA
wild-type, pH 7.5, 30°C
Mus musculus
0.17
-
butanoyl-CoA
mutant R85K, pH 7.5, 30°C
Mus musculus
0.172
-
octanoyl-CoA
mutant R85K, pH 7.5, 30°C
Mus musculus
0.34
-
octanoyl-CoA
wild-type, pH 7.5, 30°C
Mus musculus
KCat/KM [mM/s]
kcat/KM Value [1/mMs-1]
kcat/KM Value Maximum [1/mMs-1]
Substrate
Commentary
Organism
Structure
0.00002
-
glycine
mutant cosubstrate succinyl-CoA, R85L/T430V, pH 7.5, 30°C
Mus musculus
0.00017
-
glycine
mutant R85K, cosubstrate glutaryl-CoA, pH 7.5, 30°C
Mus musculus
0.00018
-
glycine
mutant R85L, cosubstrate 2-hydroxybutanoyl-CoA, pH 7.5, 30°C
Mus musculus
0.0002
-
glycine
mutant R85L, cosubstrate succinyl-CoA, pH 7.5, 30°C
Mus musculus
0.0002
-
succinyl-CoA
mutant R85L/T430V, pH 7.5, 30°C
Mus musculus
0.0005
-
butanoyl-CoA
mutant R85L/T430V, pH 7.5, 30°C
Mus musculus
0.0005
-
glycine
mutant R85L, cosubstrate butanoyl-CoA, pH 7.5, 30°C; mutant R85L, cosubstrate octanoyl-CoA, pH 7.5, 30°C
Mus musculus
0.0007
-
glutaryl-CoA
mutant R85K, pH 7.5, 30°C
Mus musculus
0.0008
-
succinyl-CoA
mutant R85L, pH 7.5, 30°C
Mus musculus
0.0012
-
glutaryl-CoA
mutant R85L, pH 7.5, 30°C
Mus musculus
0.0018
-
2-hydroxybutanoyl-CoA
mutant R85L, pH 7.5, 30°C
Mus musculus
0.0023
-
glycine
mutant R85K, cosubstrate 2-hydroxybutanoyl-CoA, pH 7.5, 30°C
Mus musculus
0.0028
-
glycine
wild-type, cosubstrate 2-hydroxybutanoyl-CoA, pH 7.5, 30°C
Mus musculus
0.0035
-
butanoyl-CoA
mutant R85L, pH 7.5, 30°C
Mus musculus
0.0043
-
glycine
wild-type, cosubstrate butanoyl-CoA, pH 7.5, 30°C
Mus musculus
0.0048
-
glycine
wild-type, cosubstrate glutaryl-CoA, pH 7.5, 30°C
Mus musculus
0.005
-
glycine
mutant R85K, cosubstrate succinyl-CoA, pH 7.5, 30°C
Mus musculus
0.0067
-
glycine
wild-type, cosubstrate succinyl-CoA, pH 7.5, 30°C
Mus musculus
0.0068
-
glutaryl-CoA
wild-type, pH 7.5, 30°C
Mus musculus
0.007
-
2-hydroxybutanoyl-CoA
wild-type, pH 7.5, 30°C
Mus musculus
0.0083
-
glycine
mutant R85K, cosubstrate butanoyl-CoA, pH 7.5, 30°C
Mus musculus
0.0085
-
2-hydroxybutanoyl-CoA
mutant R85K, pH 7.5, 30°C
Mus musculus
0.0087
-
glycine
mutant R85K, cosubstrate octanoyl-CoA, pH 7.5, 30°C
Mus musculus
0.0089
-
succinyl-CoA
mutant R85K, pH 7.5, 30°C
Mus musculus
0.02
-
butanoyl-CoA
wild-type, pH 7.5, 30°C
Mus musculus
0.02
-
glycine
mutant cosubstrate octanoyl-CoA, R85L/T430V, pH 7.5, 30°C; wild-type, cosubstrate octanoyl-CoA, pH 7.5, 30°C
Mus musculus
0.022
-
2-hydroxybutanoyl-CoA
mutant R85L/T430V, pH 7.5, 30°C
Mus musculus
0.055
-
octanoyl-CoA
mutant R85L, pH 7.5, 30°C
Mus musculus
0.062
-
butanoyl-CoA
mutant R85K, pH 7.5, 30°C
Mus musculus
0.113
-
octanoyl-CoA
wild-type, pH 7.5, 30°C
Mus musculus
0.117
-
octanoyl-CoA
mutant R85K, pH 7.5, 30°C
Mus musculus
0.13
-
glycine
mutant R85L, cosubstrate glutaryl-CoA, pH 7.5, 30°C
Mus musculus
0.55
-
succinyl-CoA
wild-type, pH 7.5, 30°C
Mus musculus
KCat/KM [mM/s] (protein specific)
KCat/KM Value [1/mMs-1]
KCat/KM Value Maximum [1/mMs-1]
Substrate
Commentary
Organism
Structure
0.00002
-
glycine
mutant cosubstrate succinyl-CoA, R85L/T430V, pH 7.5, 30°C
Mus musculus
0.00017
-
glycine
mutant R85K, cosubstrate glutaryl-CoA, pH 7.5, 30°C
Mus musculus
0.00018
-
glycine
mutant R85L, cosubstrate 2-hydroxybutanoyl-CoA, pH 7.5, 30°C
Mus musculus
0.0002
-
glycine
mutant R85L, cosubstrate succinyl-CoA, pH 7.5, 30°C
Mus musculus
0.0002
-
succinyl-CoA
mutant R85L/T430V, pH 7.5, 30°C
Mus musculus
0.0005
-
butanoyl-CoA
mutant R85L/T430V, pH 7.5, 30°C
Mus musculus
0.0005
-
glycine
mutant R85L, cosubstrate butanoyl-CoA, pH 7.5, 30°C; mutant R85L, cosubstrate octanoyl-CoA, pH 7.5, 30°C
Mus musculus
0.0007
-
glutaryl-CoA
mutant R85K, pH 7.5, 30°C
Mus musculus
0.0008
-
succinyl-CoA
mutant R85L, pH 7.5, 30°C
Mus musculus
0.0012
-
glutaryl-CoA
mutant R85L, pH 7.5, 30°C
Mus musculus
0.0018
-
2-hydroxybutanoyl-CoA
mutant R85L, pH 7.5, 30°C
Mus musculus
0.0023
-
glycine
mutant R85K, cosubstrate 2-hydroxybutanoyl-CoA, pH 7.5, 30°C
Mus musculus
0.0028
-
glycine
wild-type, cosubstrate 2-hydroxybutanoyl-CoA, pH 7.5, 30°C
Mus musculus
0.0035
-
butanoyl-CoA
mutant R85L, pH 7.5, 30°C
Mus musculus
0.0043
-
glycine
wild-type, cosubstrate butanoyl-CoA, pH 7.5, 30°C
Mus musculus
0.0048
-
glycine
wild-type, cosubstrate glutaryl-CoA, pH 7.5, 30°C
Mus musculus
0.005
-
glycine
mutant R85K, cosubstrate succinyl-CoA, pH 7.5, 30°C
Mus musculus
0.0067
-
glycine
wild-type, cosubstrate succinyl-CoA, pH 7.5, 30°C
Mus musculus
0.0068
-
glutaryl-CoA
wild-type, pH 7.5, 30°C
Mus musculus
0.007
-
2-hydroxybutanoyl-CoA
wild-type, pH 7.5, 30°C
Mus musculus
0.0083
-
glycine
mutant R85K, cosubstrate butanoyl-CoA, pH 7.5, 30°C
Mus musculus
0.0085
-
2-hydroxybutanoyl-CoA
mutant R85K, pH 7.5, 30°C
Mus musculus
0.0087
-
glycine
mutant R85K, cosubstrate octanoyl-CoA, pH 7.5, 30°C
Mus musculus
0.0089
-
succinyl-CoA
mutant R85K, pH 7.5, 30°C
Mus musculus
0.02
-
butanoyl-CoA
wild-type, pH 7.5, 30°C
Mus musculus
0.02
-
glycine
mutant cosubstrate octanoyl-CoA, R85L/T430V, pH 7.5, 30°C; wild-type, cosubstrate octanoyl-CoA, pH 7.5, 30°C
Mus musculus
0.022
-
2-hydroxybutanoyl-CoA
mutant R85L/T430V, pH 7.5, 30°C
Mus musculus
0.055
-
octanoyl-CoA
mutant R85L, pH 7.5, 30°C
Mus musculus
0.062
-
butanoyl-CoA
mutant R85K, pH 7.5, 30°C
Mus musculus
0.113
-
octanoyl-CoA
wild-type, pH 7.5, 30°C
Mus musculus
0.117
-
octanoyl-CoA
mutant R85K, pH 7.5, 30°C
Mus musculus
0.13
-
glycine
mutant R85L, cosubstrate glutaryl-CoA, pH 7.5, 30°C
Mus musculus
0.55
-
succinyl-CoA
wild-type, pH 7.5, 30°C
Mus musculus
Other publictions for EC 2.3.1.37
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
735604
Ogawa-Otomo
Aminolevulinate synthase 2 med ...
Xenopus laevis
Biochem. Biophys. Res. Commun.
456
476-481
2015
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1
1
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735684
Fratz
Human erythroid 5-aminolevulin ...
Homo sapiens
Biochemistry
54
5617-5631
2015
-
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1
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2
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1
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1
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5
5
-
-
-
736116
Stojanovski
Murine erythroid 5-aminolevuli ...
Mus musculus
FEBS open bio
5
824-831
2015
-
-
1
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1
-
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5
-
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1
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4
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1
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1
1
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5
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1
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1
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2
1
1
-
-
2
1
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-
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2
2
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2
2
736491
Stojanovski
Asn-150 of murine erythroid 5- ...
Mus musculus
J. Biol. Chem.
290
30750-30761
2015
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6
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2
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1
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6
1
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1
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6
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12
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1
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1
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2
-
1
-
-
6
1
-
-
-
-
2
2
-
12
12
735711
Stojanovski
Catalytically active alkaline ...
Mus musculus
Biochim. Biophys. Acta
1844
2145-2154
2014
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-
-
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1
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1
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2
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1
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1
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1
-
1
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1
-
1
2
1
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1
1
-
-
-
736454
Stojanovski
Unstable reaction intermediate ...
Mus musculus
J. Biol. Chem.
289
22915-22925
2014
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1
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1
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3
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4
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1
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4
-
1
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1
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1
1
-
-
-
737145
Fratz
Expression of murine 5-aminole ...
Mus musculus
PLoS ONE
9
e93078
2014
-
1
1
-
4
-
1
-
1
-
-
1
-
5
-
-
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-
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1
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1
1
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4
-
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1
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1
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1
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-
1
-
-
-
-
-
-
-
-
-
1
2
2
1
-
-
736819
Bishop
Molecular expression and chara ...
Homo sapiens
Mol. Med.
19
18-25
2013
-
-
1
-
3
-
-
12
-
-
2
1
-
2
-
-
1
-
-
-
-
-
1
1
1
-
2
-
1
-
-
1
-
-
-
-
-
1
1
-
3
-
-
-
-
12
-
-
2
1
-
-
-
1
-
-
-
-
1
1
1
-
2
-
1
-
-
-
-
1
1
-
-
-
719402
Shaik
Sigma-Aminolevulinate synthase ...
Drosophila melanogaster
Eur. J. Cell Biol.
91
204-215
2012
-
-
-
-
-
-
-
-
1
-
-
-
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1
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1
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1
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1
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1
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1
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1
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-
-
1
-
-
-
-
-
-
-
-
-
1
1
-
-
-
719419
Kadirvel
The carboxyl-terminal region o ...
Homo sapiens
Exp. Hematol.
40
477-486.e1
2012
-
-
1
-
4
-
-
-
-
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-
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3
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-
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1
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1
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1
1
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4
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1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
718696
Turbeville
Functional asymmetry for the a ...
Mus musculus
Arch. Biochem. Biophys.
511
107-117
2011
-
-
1
-
1
-
-
8
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
1
-
-
4
1
-
-
1
-
-
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-
1
1
-
1
-
-
-
-
8
-
-
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-
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-
-
-
-
-
-
1
-
1
-
-
4
1
-
-
-
-
-
-
-
-
-
718890
Zhang
Hypoxic induction of human ery ...
Homo sapiens
Biochemistry
50
1194-1202
2011
-
-
-
-
-
-
-
-
-
-
-
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2
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2
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2
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
2
-
-
720074
Kiatpapan
Production of 5-aminolevulinic ...
Acidipropionibacterium acidipropionici
J. Biosci. Bioeng.
111
425-428
2011
-
1
-
-
-
-
-
-
-
-
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2
-
-
-
-
-
-
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1
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-
-
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1
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1
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1
-
1
-
-
-
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-
-
-
-
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-
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-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
703095
Huang
Erythroid 5-aminolevulinate sy ...
Homo sapiens
Cell Biochem. Funct.
28
122-125
2010
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
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-
-
1
-
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-
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1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
703855
Okano
Indispensable function for emb ...
Mus musculus
Genes Cells
15
77-89
2010
-
-
-
-
-
-
-
-
-
-
-
-
-
4
-
-
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-
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9
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-
9
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
704690
Lendrihas
Serine 254 enhances an induced ...
Mus musculus
J. Biol. Chem.
285
3351-3359
2010
-
-
-
-
2
-
-
6
-
-
-
-
-
6
-
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1
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1
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3
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2
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6
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
3
-
-
-
-
-
-
-
-
6
6
719861
Lendrihas
Targeting the active site gate ...
Escherichia coli
J. Biol. Chem.
285
13704-13711
2010
-
-
-
-
9
-
-
16
-
-
-
-
-
3
-
-
-
-
-
-
-
-
1
-
1
-
-
8
1
-
-
1
-
-
-
-
-
-
1
-
9
-
-
-
-
16
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
8
1
-
-
-
-
-
-
-
-
-
691351
Lin
Characterization of 5-aminolev ...
Agrobacterium tumefaciens
Biores. Technol.
100
2293-2297
2009
-
1
1
-
-
-
1
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
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-
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1
1
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-
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1
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-
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-
-
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
701767
Liu
d-Glucose enhanced 5-aminolevu ...
Agrobacterium tumefaciens
Appl. Biochem. Biotechnol.
160
822-830
2009
-
1
1
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
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1
1
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-
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
703124
du Plessis
Functional analysis of the 5 r ...
Homo sapiens
Cell. Mol. Biol.
55
20-30
2009
-
-
-
-
1
-
-
-
-
-
-
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3
-
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-
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1
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-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
703125
Buzaleh
Induction of hepatic aminolevu ...
Mus musculus
Cell. Mol. Biol.
55
38-44
2009
-
1
-
-
-
-
-
-
-
-
-
-
-
5
-
-
-
-
-
-
-
-
-
-
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-
-
-
-
-
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-
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1
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-
-
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-
-
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
703635
Kaneko
Hypoxia induces erythroid-spec ...
Homo sapiens
FEBS J.
276
1370-1382
2009
-
1
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
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-
-
1
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-
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-
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-
2
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
705917
Dwyer
Down-regulation of aminolevuli ...
Homo sapiens
Neurosci. Lett.
460
180-184
2009
-
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
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-
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1
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-
-
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
706627
Lendrihas
Arg-85 and Thr-430 in murine 5 ...
Mus musculus
Protein Sci.
18
1847-1859
2009
-
-
-
-
3
-
-
38
-
-
-
-
-
4
-
-
-
-
-
1
-
-
5
-
-
-
-
18
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
38
-
-
-
-
-
-
-
-
-
1
-
-
5
-
-
-
-
18
-
-
-
-
-
-
-
-
33
33
685795
Han
Sodium butyrate activates eryt ...
Homo sapiens
Blood Cells Mol. Dis.
41
148-153
2008
-
-
-
-
-
-
-
-
-
-
-
-
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1
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3
-
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3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
705080
Choi
Extracellular 5-aminolevulinic ...
Rhodopseudomonas palustris
J. Microbiol. Biotechnol.
18
1136-1140
2008
-
1
1
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
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-
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-
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1
1
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-
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-
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
706104
Jung
-
Defence response produced duri ...
Bradyrhizobium japonicum
Photosynthetica
46
3-9
2008
-
1
1
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
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-
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-
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-
1
1
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Hofer
Hypoxic up-regulation of eryth ...
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5-Aminolevulinic acid synthase ...
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Lysine-313 of 5-aminolevulinat ...
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Aspartate-279 in aminolevulina ...
Mus musculus
Biochemistry
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1998
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2
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Role of arginine 439 in substr ...
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Biochemistry
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1998
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1
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Dailey
Expression and purification of ...
Gallus gallus, Homo sapiens, Mus musculus, Rattus norvegicus
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281
336-340
1997
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4
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3
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4
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4
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4
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Zavgorodnyaya
Yeast 5-aminolevulinate syntha ...
Saccharomyces cerevisiae
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486851
Gong
Mutations at a glycine loop in ...
Mus musculus, Rattus norvegicus
Biochemistry
35
14109-14117
1996
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486852
Tan
Active site of 5-aminolevulina ...
Mus musculus, Saccharomyces cerevisiae
Biochemistry
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1996
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1
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4
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Ferreira
Aminolevulinate synthase: lysi ...
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Protein Sci.
4
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1995
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1
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3
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486850
Ferreira
5-Aminolevulinate synthase and ...
Agrobacterium tumefaciens, Aspergillus nidulans, Bradyrhizobium japonicum, Euglena gracilis, Gallus gallus, Homo sapiens, Mus musculus, Paracoccus denitrificans, Rattus norvegicus, Rhodobacter capsulatus, Rhodobacter sphaeroides, Saccharomyces cerevisiae, Sinorhizobium meliloti
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14
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486824
Ferreira
Expression of mammalian 5-amin ...
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1
1
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2
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1
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1
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1
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2
1
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1
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-
-
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486847
Lake-Bullock
Biphasic ordered induction of ...
Mus musculus
Mol. Cell. Biol.
13
7122-7132
1993
3
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1
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1
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486848
Munakata
Purification and structure of ...
Rattus norvegicus
J. Biochem.
114
103-111
1993
1
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1
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1
2
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3
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1
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1
1
1
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1
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-
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486808
Bishop
Human delta-aminolevulinate sy ...
Homo sapiens
Genomics
7
207-214
1990
-
-
-
-
-
-
-
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1
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2
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1
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2
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486814
Ades
Properties of chicken erythroc ...
Gallus gallus
Int. J. Biochem.
20
965-969
1988
-
-
-
-
-
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1
2
1
-
2
-
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3
-
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1
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4
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1
1
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1
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1
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1
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1
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2
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1
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4
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1
1
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1
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-
-
-
-
-
-
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486815
Viale
-
Extraction and characterizatio ...
Rhodopseudomonas palustris
Comp. Biochem. Physiol. B
87
607-613
1987
1
-
-
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2
1
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1
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1
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1
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2
1
1
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1
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1
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1
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2
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1
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1
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1
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2
2
1
1
-
-
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1
-
-
-
-
-
-
-
-
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486816
Fernandez
Trout (Salmo gairdenri R.) liv ...
Oncorhynchus mykiss
Comp. Biochem. Physiol. B
86
245-249
1987
-
-
-
-
-
-
-
-
2
-
2
-
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2
-
-
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-
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2
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1
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1
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1
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1
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2
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2
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2
-
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1
-
-
-
-
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1
-
-
-
-
-
-
-
-
-
486818
Borthwick
Purification of hepatic mitoch ...
Gallus gallus, Rattus norvegicus
Methods Enzymol.
123
395-401
1986
-
-
-
-
-
-
-
-
6
-
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2
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2
-
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2
-
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4
2
4
4
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2
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2
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2
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6
-
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2
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2
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4
2
4
4
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
486819
Jordan
Purification of 5-aminolevulin ...
Rhodobacter sphaeroides
Methods Enzymol.
123
435-443
1986
-
-
-
-
-
-
5
-
-
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2
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1
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1
1
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1
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5
1
1
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1
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1
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5
-
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2
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1
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1
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5
1
1
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-
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-
-
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-
-
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-
486839
Sato
-
Purification and some properti ...
Rhodobacter sphaeroides, Serratia plymuthica
Agric. Biol. Chem.
49
3415-3421
1985
2
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4
2
4
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2
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2
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2
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2
1
2
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2
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2
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2
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2
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2
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4
-
2
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4
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2
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2
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2
1
2
-
2
-
-
-
2
-
-
-
-
-
-
-
-
-
486840
Sato
-
Occurence and some properties ...
Serratia plymuthica
Agric. Biol. Chem.
49
3423-3428
1985
-
-
-
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1
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1
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1
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1
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1
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1
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1
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1
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1
-
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-
-
-
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-
-
-
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-
-
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486835
Volland
Isolation and properties of 5- ...
Saccharomyces cerevisiae
Eur. J. Biochem.
142
551-557
1984
-
-
-
-
-
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4
2
2
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2
-
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2
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1
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1
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1
1
1
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1
1
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1
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1
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4
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2
2
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2
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1
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1
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1
1
1
-
-
-
1
1
-
-
-
-
-
-
-
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486823
Scotto
The characterization and submi ...
Rattus norvegicus
J. Biol. Chem.
258
81-90
1983
-
-
-
-
-
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-
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3
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2
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-
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2
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1
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1
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1
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1
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3
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2
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1
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-
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1
-
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-
-
-
-
-
-
-
-
486836
Borthwick
Purification of 5-aminolaevuli ...
Gallus gallus
Eur. J. Biochem.
129
615-620
1983
-
-
-
-
-
-
-
-
1
-
1
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1
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1
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-
2
1
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1
1
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-
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1
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1
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-
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1
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1
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1
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2
1
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1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
486838
Srivastava
Purification of rat liver mito ...
Rattus norvegicus
Biochem. Biophys. Res. Commun.
109
305-312
1982
-
-
-
-
-
-
-
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1
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2
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1
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1
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1
1
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1
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1
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1
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1
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2
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1
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1
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
486817
Kreit
Control of 5-aminolevulinic ac ...
Rhodospirillum rubrum
Biochimie
63
439-444
1981
1
-
-
-
-
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4
-
-
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1
-
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4
-
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1
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1
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1
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1
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1
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1
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4
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1
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1
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1
-
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-
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1
-
-
-
-
-
-
-
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486822
Simpson
Purification of a specific act ...
Rattus norvegicus
J. Biol. Chem.
255
1630-1634
1980
2
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-
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-
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-
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2
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4
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2
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-
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2
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1
1
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1
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1
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2
-
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1
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2
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4
-
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-
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2
-
-
1
1
-
-
-
-
1
-
-
-
-
-
-
-
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486834
Nakakuki
Purification and some properti ...
Rattus norvegicus
J. Biol. Chem.
255
1738-1745
1980
-
-
-
-
-
-
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3
3
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2
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2
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1
-
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2
1
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1
1
1
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1
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1
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1
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-
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-
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3
3
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2
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1
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2
1
-
1
1
1
-
-
-
1
-
-
-
-
-
-
-
-
-
486825
Davies
Control of 5-aminolaevulinate ...
Rhodobacter sphaeroides
Biochem. J.
177
649-659
1979
-
-
-
-
-
-
-
-
-
-
3
-
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1
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1
-
-
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1
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1
1
1
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-
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1
-
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1
-
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-
-
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1
-
-
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-
3
-
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1
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1
-
1
1
1
-
-
-
1
-
-
-
-
-
-
-
-
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486826
Davies
Control of 5-aminolaevulinate ...
Rhodobacter sphaeroides
Biochem. J.
177
661-671
1979
-
-
-
-
-
-
-
-
-
-
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-
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1
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1
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1
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1
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-
-
-
-
-
-
-
1
-
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-
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-
-
1
-
-
-
-
-
-
-
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-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
486833
Paterniti
delta-Aminolevulinic acid synt ...
Rattus norvegicus
J. Biol. Chem.
254
6112-6118
1979
-
-
-
-
-
-
3
1
2
2
2
-
-
2
-
-
1
-
-
2
1
1
1
1
-
-
-
-
1
-
-
1
-
-
-
-
-
-
1
-
-
-
-
3
-
1
2
2
2
-
-
-
-
1
-
2
1
1
1
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
486837
Ohashi
Purification and some properti ...
Rattus norvegicus
J. Biochem.
85
239-247
1979
-
-
-
-
-
-
2
2
2
2
2
-
-
2
-
-
1
-
-
2
1
-
1
1
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
2
-
2
2
2
2
-
-
-
-
1
-
2
1
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
486821
Nandi
Studies on delta-aminolevulini ...
Rhodobacter sphaeroides
J. Biol. Chem.
253
8872-8877
1978
-
-
-
-
-
-
4
-
-
-
-
-
-
2
-
-
-
1
-
-
-
-
1
-
-
-
-
-
-
-
-
1
2
-
-
-
-
-
1
-
-
-
-
4
2
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
486827
Ibrahim
Hemin feedback inhibition at r ...
Oryctolagus cuniculus
Biochem. Biophys. Res. Commun.
80
722-728
1978
-
-
-
-
-
-
1
-
2
-
-
-
-
1
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
486832
Whiting
delta-Aminolevulinic acid synt ...
Gallus gallus
J. Biol. Chem.
251
1340-1346
1976
-
-
-
-
-
-
4
-
-
4
2
-
-
1
-
-
1
-
-
2
1
2
1
1
-
-
-
-
-
-
-
1
1
-
-
-
-
-
1
-
-
-
-
4
1
-
-
4
2
-
-
-
-
1
-
2
1
2
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
486831
Clement-Metral
5-Aminolevulinic-acid syntheta ...
Rhodobacter sphaeroides, Rhodobacter sphaeroides Y
Eur. J. Biochem.
59
73-77
1975
-
-
-
-
-
-
2
-
-
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1
-
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6
-
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1
-
-
-
1
-
2
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
2
-
-
-
-
1
-
-
-
-
1
-
-
1
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
486830
Hayasaka
Control of delta-aminolevulina ...
Rhodobacter sphaeroides
J. Biochem.
76
157-168
1974
2
-
-
-
-
-
2
-
-
-
-
-
-
2
-
-
1
-
-
-
1
-
1
-
-
-
-
-
-
-
-
1
-
-
-
2
-
-
1
-
-
-
-
2
-
-
-
-
-
-
-
-
-
1
-
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
486841
Murthy
Solubilization and partial pur ...
Rattus norvegicus
Biochim. Biophys. Acta
350
240-246
1974
1
-
-
-
-
-
3
-
2
-
-
-
-
2
-
-
1
-
-
4
1
-
1
-
-
-
-
-
-
-
-
1
-
-
-
1
-
-
1
-
-
-
-
3
-
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2
-
-
-
-
-
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1
-
4
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
486809
Ramaswamy
delta-Aminolevulinic acid synt ...
Solanum tuberosum
Biochim. Biophys. Acta
293
269-277
1973
2
-
-
-
-
-
4
-
-
1
-
1
-
1
-
-
-
-
-
1
2
1
2
-
1
-
1
-
1
-
-
1
-
-
-
2
-
-
1
-
-
-
-
4
-
-
-
1
-
1
-
-
-
-
-
1
2
1
2
-
1
-
1
-
1
-
-
-
-
-
-
-
-
-
486810
Tait
Aminolaevulinate synthetase of ...
Paracoccus denitrificans
Biochem. J.
131
389-403
1973
-
-
-
-
-
-
4
3
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1
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-
1
-
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1
-
-
1
2
-
1
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
1
-
-
-
-
4
-
3
-
-
1
-
-
-
-
1
-
1
2
-
1
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
486844
Fanica-Gaignier
5-Aminolevulinic-acid syntheta ...
Rhodobacter sphaeroides, Rhodobacter sphaeroides Y
Eur. J. Biochem.
40
13-18
1973
-
-
-
-
-
-
-
-
-
-
2
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6
-
-
1
-
-
-
2
1
2
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
2
-
-
-
-
1
-
-
2
1
2
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
486845
Fanica-Gaignier
5-Aminolevulinic-acid syntheta ...
Rhodobacter sphaeroides, Rhodobacter sphaeroides Y
Eur. J. Biochem.
40
19-24
1973
-
-
-
-
-
-
4
1
-
-
-
-
-
6
-
-
-
1
-
-
-
-
2
-
-
-
-
-
-
-
-
1
3
-
-
-
-
-
1
-
-
-
-
4
3
1
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
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-
-
-
-
-
-
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486812
Scholnick
Souble delta-aminolevulinic ac ...
Rattus norvegicus
J. Biol. Chem.
247
4126-4131
1972
1
-
-
-
-
1
-
4
1
1
2
1
-
1
-
-
1
-
-
1
1
-
3
-
-
-
-
-
2
-
1
1
-
-
-
1
-
-
1
-
-
1
-
-
-
4
1
1
2
1
-
-
-
1
-
1
1
-
3
-
-
-
-
-
2
-
1
-
-
-
-
-
-
-
486813
Scholnick
Soluble delta-aminolevulinic a ...
Rattus norvegicus
J. Biol. Chem.
247
4132-4137
1972
-
-
-
-
-
-
14
-
1
-
-
-
-
1
-
-
-
1
-
1
-
-
1
-
-
-
-
-
-
-
-
1
1
-
-
-
-
-
1
-
-
-
-
14
1
-
1
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
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-
-
-
-
486820
Jordan
-
delta-Aminolevulinic acid synt ...
Cavia porcellus, Gallus gallus, Homo sapiens, no activity in Chromatium sp., Novispirillum itersonii, Oryctolagus cuniculus, Propionibacterium freudenreichii subsp. shermanii, Rattus norvegicus, Rhodobacter sphaeroides, Rhodospirillum rubrum, Saccharomyces cerevisiae, Spinacia oleracea
The Enzymes, 3rd Ed. (Boyer, P. D. , ed. )
7
339-356
1972
3
-
-
-
-
-
110
9
13
-
5
21
-
12
-
-
3
10
-
10
8
-
62
-
-
-
2
-
-
-
-
11
-
-
-
3
-
-
11
-
-
-
-
110
-
9
13
-
5
21
-
-
-
3
-
10
8
-
62
-
-
-
2
-
-
-
-
-
-
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-
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-
486828
Porra
The nature of the inhibition o ...
Rhodobacter sphaeroides
Arch. Biochem. Biophys.
148
37-43
1972
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-
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-
-
-
1
-
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-
1
-
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1
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1
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1
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-
-
1
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-
1
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-
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-
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486842
Yubisui
delta-Aminolevulinic acid synt ...
Rhodobacter sphaeroides
Arch. Biochem. Biophys.
150
77-85
1972
1
-
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-
1
12
-
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-
1
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-
1
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-
1
-
-
-
1
1
1
-
-
-
-
-
1
-
-
1
-
-
-
1
-
-
1
-
-
1
-
12
-
-
-
-
1
-
-
-
-
1
-
-
1
1
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
486843
Whiting
Purification and properties of ...
Cavia porcellus, Rattus norvegicus
J. Biol. Chem.
247
6818-6826
1972
-
-
-
-
-
-
2
3
5
-
2
-
-
2
-
-
2
-
-
2
-
2
2
-
-
-
-
-
-
-
-
2
-
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-
-
-
2
-
-
-
-
2
-
3
5
-
2
-
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-
2
-
2
-
2
2
-
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-
-
-
-
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-
-
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-
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486811
Warnick
Regulation of prophyrin biosyn ...
Rhodobacter sphaeroides
J. Biol. Chem.
246
6880-6885
1971
1
-
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-
1
3
-
-
1
1
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-
1
-
-
1
-
-
-
1
2
2
2
-
-
1
-
1
-
-
1
-
-
-
1
-
-
1
-
-
1
-
3
-
-
-
1
1
-
-
-
-
1
-
-
1
2
2
2
-
-
1
-
1
-
-
-
-
-
-
-
-
-
486829
Tuboi
Control of delta-aminolevulina ...
Rhodobacter sphaeroides
Arch. Biochem. Biophys.
146
282-290
1971
-
-
-
-
-
-
-
-
-
-
2
-
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1
-
-
1
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-
-
1
-
1
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-
-
1
-
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-
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-
-
1
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-
-
2
-
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-
-
1
-
-
1
-
1
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