Literature summary for 2.3.1.37 extracted from

Cox, T.C.; Sadlon, T.J.; Schwarz, Q.P.; Matthews, C.S.; Wise, P.D.; Cox, L.L.; Bottomley, S.S.; May, B.K.
The major splice variant of human 5-aminolevulinate synthase-2 contributes significantly to erythroid heme biosynthesis (2004), Int. J. Biochem. Cell Biol., 36, 281-295.

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Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
mitochondrion	-	Homo sapiens	5739	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	major splice variant of enzyme isoform ALAS2, expression in Escherichia coli	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
proteolytic modification	first 49 amino acids of enzyme pre-protein are mitochondrial targeting sequence	Homo sapiens

Source Tissue

Source Tissue	Comment	Organism	Textmining
reticulocyte	-	Homo sapiens	-

Subunits

Subunits	Comment	Organism
More	splice variant lacking exon 4-encoded sequence produces a functional enzyme with slightly reduced activity compared to full-length enzyme. Interaction of both full-length enzyme and splice variant lacking exon 4-encoded sequence with succinyl CoA synthase	Homo sapiens

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Release 2023.1 (January 2023)