Activating Compound | Comment | Organism | Structure |
---|---|---|---|
2-allyl-2-isopropylacetamide | strong induction of enzyme in liver | Gallus gallus | |
2-allyl-2-isopropylacetamide | strong induction of enzyme in liver | Rattus norvegicus |
Cloned (Comment) | Organism |
---|---|
- |
Sinorhizobium meliloti |
- |
Mus musculus |
- |
Cereibacter sphaeroides |
- |
Bradyrhizobium japonicum |
- |
Rhodobacter capsulatus |
cDNA from erythroid genetic library | Gallus gallus |
gene hem, functional complementation of Saccharomyces cerevisiae hem1 mutant | Saccharomyces cerevisiae |
liver and erythroid enzyme | Homo sapiens |
liver enzyme | Rattus norvegicus |
General Stability | Organism |
---|---|
enzyme is susceptible to proteolytic degradation during isolation, tendency to form aggregates | Gallus gallus |
enzyme is susceptible to proteolytic degradation during isolation, tendency to form aggregates | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
hemin | - |
Cereibacter sphaeroides | |
hemin | inhibition of the import of the enzyme into the mitochondrial matrix | Gallus gallus | |
hemin | inhibition of the import of the enzyme into the mitochondrial matrix | Homo sapiens | |
hemin | inhibition of the import of the enzyme into the mitochondrial matrix | Mus musculus | |
hemin | - |
Paracoccus denitrificans | |
hemin | inhibition of the import of the enzyme into the mitochondrial matrix | Rattus norvegicus | |
hemin | inhibition of the import of the enzyme into the mitochondrial matrix | Saccharomyces cerevisiae |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Gallus gallus | 5739 | - |
mitochondrion | - |
Homo sapiens | 5739 | - |
mitochondrion | - |
Rattus norvegicus | 5739 | - |
mitochondrion | - |
Saccharomyces cerevisiae | 5739 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
additional information | - |
amino acid sequence alignment | Gallus gallus |
additional information | - |
amino acid sequence alignment | Paracoccus denitrificans |
additional information | - |
amino acid sequence alignment | Mus musculus |
additional information | - |
amino acid sequence alignment | Homo sapiens |
additional information | - |
amino acid sequence alignment | Rattus norvegicus |
additional information | - |
amino acid sequence alignment | Saccharomyces cerevisiae |
additional information | - |
amino acid sequence alignment | Aspergillus nidulans |
additional information | - |
amino acid sequence alignment | Cereibacter sphaeroides |
additional information | - |
amino acid sequence alignment | Bradyrhizobium japonicum |
additional information | - |
amino acid sequence alignment | Rhodobacter capsulatus |
additional information | - |
amino acid sequence alignment | Agrobacterium tumefaciens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
succinyl-CoA + glycine | Gallus gallus | regulatory mechanisms in hepatic and erythroid cells | 5-aminolevulinate + CoA + CO2 | - |
? | |
succinyl-CoA + glycine | Mus musculus | regulatory mechanisms in hepatic and erythroid cells | 5-aminolevulinate + CoA + CO2 | - |
? | |
succinyl-CoA + glycine | Homo sapiens | regulatory mechanisms in hepatic and erythroid cells | 5-aminolevulinate + CoA + CO2 | - |
? | |
succinyl-CoA + glycine | Rattus norvegicus | regulatory mechanisms in hepatic and erythroid cells | 5-aminolevulinate + CoA + CO2 | - |
? | |
succinyl-CoA + glycine | Saccharomyces cerevisiae | regulatory mechanisms in hepatic and erythroid cells | 5-aminolevulinate + CoA + CO2 | - |
? | |
succinyl-CoA + glycine | Cereibacter sphaeroides | regulatory mechanisms in hepatic and erythroid cells | 5-aminolevulinate + CoA + CO2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Agrobacterium tumefaciens | - |
- |
- |
Aspergillus nidulans | - |
- |
- |
Bradyrhizobium japonicum | - |
- |
- |
Cereibacter sphaeroides | - |
- |
- |
Euglena gracilis | - |
- |
- |
Gallus gallus | - |
- |
- |
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Paracoccus denitrificans | - |
i.e. Paracoccus denitrificans | - |
Rattus norvegicus | - |
- |
- |
Rhodobacter capsulatus | - |
- |
- |
Saccharomyces cerevisiae | - |
- |
- |
Sinorhizobium meliloti | - |
- |
- |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2 | mechanism | Gallus gallus | |
succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2 | mechanism | Paracoccus denitrificans | |
succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2 | mechanism | Mus musculus | |
succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2 | mechanism | Homo sapiens | |
succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2 | mechanism | Rattus norvegicus | |
succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2 | mechanism | Saccharomyces cerevisiae | |
succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2 | mechanism | Euglena gracilis | |
succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2 | mechanism | Cereibacter sphaeroides | |
succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2 | cysteine in heme-regulatory motif | Mus musculus | |
succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2 | pyridoxal 5'-phosphate binding site, sequence and function of glycine-rich motif | Mus musculus | |
succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2 | ordered bi-bi mechanism in which glycine binds first and 5-aminolevulinic acid dissociates last | Cereibacter sphaeroides |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
erythrocyte | - |
Gallus gallus | - |
erythrocyte | - |
Homo sapiens | - |
liver | - |
Gallus gallus | - |
liver | - |
Homo sapiens | - |
liver | - |
Rattus norvegicus | - |
additional information | enzyme is synthezised in the cytosol as the precursor protein and then imported into the mitochondria matrix and cleaved to the mature enzyme, the targeting information is encoded in nonoverlapping regions of the presequence | Gallus gallus | - |
additional information | enzyme is synthezised in the cytosol as the precursor protein and then imported into the mitochondria matrix and cleaved to the mature enzyme, the targeting information is encoded in nonoverlapping regions of the presequence | Mus musculus | - |
additional information | enzyme is synthezised in the cytosol as the precursor protein and then imported into the mitochondria matrix and cleaved to the mature enzyme, the targeting information is encoded in nonoverlapping regions of the presequence | Homo sapiens | - |
additional information | enzyme is synthezised in the cytosol as the precursor protein and then imported into the mitochondria matrix and cleaved to the mature enzyme, the targeting information is encoded in nonoverlapping regions of the presequence | Rattus norvegicus | - |
additional information | enzyme is synthezised in the cytosol as the precursor protein and then imported into the mitochondria matrix and cleaved to the mature enzyme, the targeting information is encoded in nonoverlapping regions of the presequence | Saccharomyces cerevisiae | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
succinyl-CoA + glycine | - |
Mus musculus | 5-aminolevulinate + CoA + CO2 | - |
? | |
succinyl-CoA + glycine | absolutely specific for glycine | Gallus gallus | 5-aminolevulinate + CoA + CO2 | - |
? | |
succinyl-CoA + glycine | absolutely specific for glycine | Paracoccus denitrificans | 5-aminolevulinate + CoA + CO2 | - |
? | |
succinyl-CoA + glycine | absolutely specific for glycine | Homo sapiens | 5-aminolevulinate + CoA + CO2 | - |
? | |
succinyl-CoA + glycine | absolutely specific for glycine | Rattus norvegicus | 5-aminolevulinate + CoA + CO2 | - |
? | |
succinyl-CoA + glycine | absolutely specific for glycine | Saccharomyces cerevisiae | 5-aminolevulinate + CoA + CO2 | - |
? | |
succinyl-CoA + glycine | absolutely specific for glycine | Euglena gracilis | 5-aminolevulinate + CoA + CO2 | - |
? | |
succinyl-CoA + glycine | absolutely specific for glycine | Cereibacter sphaeroides | 5-aminolevulinate + CoA + CO2 | - |
? | |
succinyl-CoA + glycine | regulatory mechanisms in hepatic and erythroid cells | Gallus gallus | 5-aminolevulinate + CoA + CO2 | - |
? | |
succinyl-CoA + glycine | regulatory mechanisms in hepatic and erythroid cells | Mus musculus | 5-aminolevulinate + CoA + CO2 | - |
? | |
succinyl-CoA + glycine | regulatory mechanisms in hepatic and erythroid cells | Homo sapiens | 5-aminolevulinate + CoA + CO2 | - |
? | |
succinyl-CoA + glycine | regulatory mechanisms in hepatic and erythroid cells | Rattus norvegicus | 5-aminolevulinate + CoA + CO2 | - |
? | |
succinyl-CoA + glycine | regulatory mechanisms in hepatic and erythroid cells | Saccharomyces cerevisiae | 5-aminolevulinate + CoA + CO2 | - |
? | |
succinyl-CoA + glycine | regulatory mechanisms in hepatic and erythroid cells | Cereibacter sphaeroides | 5-aminolevulinate + CoA + CO2 | - |
? |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
pyridoxal 5'-phosphate | - |
Sinorhizobium meliloti | |
pyridoxal 5'-phosphate | - |
Aspergillus nidulans | |
pyridoxal 5'-phosphate | - |
Bradyrhizobium japonicum | |
pyridoxal 5'-phosphate | - |
Rhodobacter capsulatus | |
pyridoxal 5'-phosphate | - |
Agrobacterium tumefaciens | |
pyridoxal 5'-phosphate | required | Gallus gallus | |
pyridoxal 5'-phosphate | required | Paracoccus denitrificans | |
pyridoxal 5'-phosphate | required | Mus musculus | |
pyridoxal 5'-phosphate | required | Homo sapiens | |
pyridoxal 5'-phosphate | required | Rattus norvegicus | |
pyridoxal 5'-phosphate | required | Saccharomyces cerevisiae | |
pyridoxal 5'-phosphate | required | Euglena gracilis | |
pyridoxal 5'-phosphate | required | Cereibacter sphaeroides |