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Literature summary for 2.3.1.37 extracted from

  • Paterniti, J.R.; Beattie, D.S.
    delta-Aminolevulinic acid synthetase from rat liver mitochondria. Purification and properties (1979), J. Biol. Chem., 254, 6112-6118.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
hemin feed-back inhibition Rattus norvegicus
monovalent cations in Mg2+-containing medium: Na+ or Li+ at 100 mM have no effect on activity, higher concentrations are totally inhibitory Rattus norvegicus
additional information presence of high salt concentration in the sample buffer and running buffer of aggregated enzyme preparation results in inactivation Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
5
-
succinyl-CoA
-
Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
Rattus norvegicus 5739
-

Metals/Ions

Metals/Ions Comment Organism Structure
Li+ in Mg2+-containing medium: at 100 mM no effect on activity, higher concentrations are totally inhibitory Rattus norvegicus
Na+ in Mg2+-containing medium: at 100 mM no effect on activity, higher concentrations are totally inhibitory Rattus norvegicus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
58000
-
2 * 58000, mitochondria, SDS-PAGE Rattus norvegicus
120000
-
gel filtration Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.035
-
purified enzyme Rattus norvegicus

Storage Stability

Storage Stability Organism
-20°C, 20% loss of activity after 1 month Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
succinyl-CoA + glycine
-
Rattus norvegicus 5-aminolevulinate + CoA + CO2
-
?

Subunits

Subunits Comment Organism
dimer 2 * 58000, mitochondria, SDS-PAGE Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
-
Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate
-
Rattus norvegicus