BRENDA - Enzyme Database show
show all sequences of 2.3.1.37

delta-Aminolevulinic acid synthetase

Jordan, P.M.; Shemin, D.; The Enzymes, 3rd Ed. (Boyer, P. D. , ed. ) 7, 339-356 (1972)
No PubMed abstract available

Data extracted from this reference:

Activating Compound
Activating Compound
Commentary
Organism
Structure
2-allyl-2-isopropylacetamide
strong induction of enzyme in liver
Cavia porcellus
2-allyl-2-isopropylacetamide
strong induction of enzyme in liver
Gallus gallus
2-allyl-2-isopropylacetamide
strong induction of enzyme in liver
Rattus norvegicus
Inhibitors
Inhibitors
Commentary
Organism
Structure
2-hydroxyethyldisulfide
-
Rhodobacter sphaeroides
2-mercaptoethanol
-
Oryctolagus cuniculus
2-oxoglutarate
-
Cavia porcellus
2-oxoglutarate
-
Gallus gallus
2-oxoglutarate
-
Homo sapiens
2-oxoglutarate
-
Oryctolagus cuniculus
2-oxoglutarate
-
Propionibacterium freudenreichii subsp. shermanii
2-oxoglutarate
-
Rattus norvegicus
2-oxoglutarate
-
Rhodobacter sphaeroides
2-oxoglutarate
-
Rhodospirillum rubrum
2-oxoglutarate
-
Saccharomyces cerevisiae
2-oxoglutarate
-
Spinacia oleracea
aminomalonate
-
Gallus gallus
aminomalonate
-
Rhodobacter sphaeroides
Aminomethylphosphonate
-
Cavia porcellus
Aminomethylphosphonate
-
Gallus gallus
Aminomethylphosphonate
-
Homo sapiens
Aminomethylphosphonate
-
Oryctolagus cuniculus
Aminomethylphosphonate
-
Propionibacterium freudenreichii subsp. shermanii
Aminomethylphosphonate
-
Rattus norvegicus
Aminomethylphosphonate
-
Rhodospirillum rubrum
Aminomethylphosphonate
-
Saccharomyces cerevisiae
Aminomethylphosphonate
-
Spinacia oleracea
Aminomethylphosphonate
-
Rhodobacter sphaeroides
beta-Alanine
-
Gallus gallus
beta-Alanine
-
Rhodobacter sphaeroides
Borohydride
in presence of pyridoxal 5'-phosphate
Rhodobacter sphaeroides
Cu2+
-
Rhodobacter sphaeroides
Cu2+
-
Rhodospirillum rubrum
cyanide
-
Gallus gallus
Diethyl aminomalonate
-
Gallus gallus
Diethyl aminomalonate
-
Rhodobacter sphaeroides
ethanolamine
-
Gallus gallus
ethanolamine
-
Rhodobacter sphaeroides
ethanolamine
-
Rhodospirillum rubrum
Fe2+
-
Rhodobacter sphaeroides
Fe3+
-
Oryctolagus cuniculus
Fe3+
no inhibition
Rhodobacter sphaeroides
ferroheme
-
Cavia porcellus
ferroheme
-
Gallus gallus
ferroheme
-
Homo sapiens
ferroheme
-
Oryctolagus cuniculus
ferroheme
-
Propionibacterium freudenreichii subsp. shermanii
ferroheme
-
Rattus norvegicus
ferroheme
-
Rhodobacter sphaeroides
ferroheme
-
Rhodospirillum rubrum
ferroheme
-
Saccharomyces cerevisiae
ferroheme
-
Spinacia oleracea
glutathione
-
Oryctolagus cuniculus
hemin
-
Homo sapiens
hemin
-
Oryctolagus cuniculus
hemin
-
Propionibacterium freudenreichii subsp. shermanii
hemin
-
Rattus norvegicus
hemin
-
Rhodospirillum rubrum
hemin
-
Spinacia oleracea
hemin
-
Gallus gallus
hemin
-
Saccharomyces cerevisiae
hemin
-
Cavia porcellus
hemin
-
Rhodobacter sphaeroides
hemoglobin
-
Cavia porcellus
hemoglobin
-
Gallus gallus
hemoglobin
-
Homo sapiens
hemoglobin
-
Oryctolagus cuniculus
hemoglobin
-
Propionibacterium freudenreichii subsp. shermanii
hemoglobin
-
Rattus norvegicus
hemoglobin
-
Rhodobacter sphaeroides
hemoglobin
-
Rhodospirillum rubrum
hemoglobin
-
Saccharomyces cerevisiae
hemoglobin
-
Spinacia oleracea
iodoacetamide
-
Rhodobacter sphaeroides
Isobutylamine
-
Gallus gallus
Isobutylamine
-
Rhodobacter sphaeroides
L-alanine
-
Gallus gallus
L-alanine
-
Rhodobacter sphaeroides
L-cysteine
-
Gallus gallus
L-Penicillamine
-
Gallus gallus
L-threonine
-
Gallus gallus
L-threonine
-
Rhodobacter sphaeroides
metalloporphyrins
containing Co2+, Zn2+ or Mg2+
Cavia porcellus
metalloporphyrins
containing Co2+, Zn2+ or Mg2+
Gallus gallus
metalloporphyrins
containing Co2+, Zn2+ or Mg2+
Homo sapiens
metalloporphyrins
containing Co2+, Zn2+ or Mg2+
Oryctolagus cuniculus
metalloporphyrins
containing Co2+, Zn2+ or Mg2+
Propionibacterium freudenreichii subsp. shermanii
metalloporphyrins
containing Co2+, Zn2+ or Mg2+
Rattus norvegicus
metalloporphyrins
containing Co2+, Zn2+ or Mg2+
Rhodobacter sphaeroides
metalloporphyrins
containing Co2+, Zn2+ or Mg2+
Rhodospirillum rubrum
metalloporphyrins
containing Co2+, Zn2+ or Mg2+
Saccharomyces cerevisiae
metalloporphyrins
containing Co2+, Zn2+ or Mg2+
Spinacia oleracea
myoglobin
-
Cavia porcellus
myoglobin
-
Gallus gallus
myoglobin
-
Homo sapiens
myoglobin
-
Oryctolagus cuniculus
myoglobin
-
Propionibacterium freudenreichii subsp. shermanii
myoglobin
-
Rattus norvegicus
myoglobin
-
Rhodobacter sphaeroides
myoglobin
-
Rhodospirillum rubrum
myoglobin
-
Saccharomyces cerevisiae
myoglobin
-
Spinacia oleracea
p-mercuribenzoate
-
Gallus gallus
p-mercuribenzoate
-
Rhodobacter sphaeroides
pyruvate
-
Cavia porcellus
pyruvate
-
Gallus gallus
pyruvate
-
Homo sapiens
pyruvate
-
Oryctolagus cuniculus
pyruvate
-
Propionibacterium freudenreichii subsp. shermanii
pyruvate
-
Rattus norvegicus
pyruvate
-
Rhodobacter sphaeroides
pyruvate
-
Rhodospirillum rubrum
pyruvate
-
Saccharomyces cerevisiae
pyruvate
-
Spinacia oleracea
KM Value [mM]
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
additional information
-
additional information
-
Cavia porcellus
additional information
-
additional information
overview
Gallus gallus
additional information
-
additional information
-
Homo sapiens
additional information
-
additional information
overview
Oryctolagus cuniculus
additional information
-
additional information
-
Propionibacterium freudenreichii subsp. shermanii
additional information
-
additional information
overview
Rattus norvegicus
additional information
-
additional information
overview
Rhodobacter sphaeroides
additional information
-
additional information
-
Saccharomyces cerevisiae
additional information
-
additional information
-
Spinacia oleracea
Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
microsome
-
Cavia porcellus
-
-
microsome
-
Homo sapiens
-
-
microsome
-
Oryctolagus cuniculus
-
-
microsome
-
Rattus norvegicus
-
-
mitochondrion
-
Oryctolagus cuniculus
5739
-
mitochondrion
-
Cavia porcellus
5739
-
mitochondrion
-
Gallus gallus
5739
-
mitochondrion
-
Rattus norvegicus
5739
-
mitochondrion
-
Homo sapiens
5739
-
additional information
synthesized in microsomes and then migrates to the mitochondria
Cavia porcellus
-
-
additional information
synthesized in microsomes and then migrates to the mitochondria
Homo sapiens
-
-
additional information
synthesized in microsomes and then migrates to the mitochondria
Oryctolagus cuniculus
-
-
additional information
synthesized in microsomes and then migrates to the mitochondria
Rattus norvegicus
-
-
Molecular Weight [Da]
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
additional information
-
-
Gallus gallus
additional information
-
-
Homo sapiens
additional information
-
-
Rattus norvegicus
additional information
-
-
Rhodobacter sphaeroides
200000
-
gel filtration
Oryctolagus cuniculus
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
succinyl-CoA + glycine
Gallus gallus
key enzyme in tetrapyrrole biosynthesis
5-aminolevulinate + CoA + CO2
-
Gallus gallus
?
succinyl-CoA + glycine
Cavia porcellus
key enzyme in tetrapyrrole biosynthesis
5-aminolevulinate + CoA + CO2
-
-
?
succinyl-CoA + glycine
Homo sapiens
key enzyme in tetrapyrrole biosynthesis
5-aminolevulinate + CoA + CO2
-
Homo sapiens
?
succinyl-CoA + glycine
Rattus norvegicus
key enzyme in tetrapyrrole biosynthesis
5-aminolevulinate + CoA + CO2
-
Rattus norvegicus
?
succinyl-CoA + glycine
Saccharomyces cerevisiae
key enzyme in tetrapyrrole biosynthesis
5-aminolevulinate + CoA + CO2
-
-
?
succinyl-CoA + glycine
Oryctolagus cuniculus
key enzyme in tetrapyrrole biosynthesis
5-aminolevulinate + CoA + CO2
-
-
?
succinyl-CoA + glycine
Rhodobacter sphaeroides
key enzyme in tetrapyrrole biosynthesis
5-aminolevulinate + CoA + CO2
-
Rhodobacter sphaeroides
?
succinyl-CoA + glycine
Spinacia oleracea
key enzyme in tetrapyrrole biosynthesis
5-aminolevulinate + CoA + CO2
-
-
?
succinyl-CoA + glycine
Propionibacterium freudenreichii subsp. shermanii
key enzyme in tetrapyrrole biosynthesis
5-aminolevulinate + CoA + CO2
-
-
?
succinyl-CoA + glycine
Rhodospirillum rubrum
key enzyme in tetrapyrrole biosynthesis
5-aminolevulinate + CoA + CO2
-
-
?
succinyl-CoA + glycine
Novispirillum itersonii
key enzyme in tetrapyrrole biosynthesis
5-aminolevulinate + CoA + CO2
-
-
?
succinyl-CoA + glycine
Gallus gallus
rate-limiting enzyme of heme biosynthesis
5-aminolevulinate + CoA + CO2
-
Gallus gallus
?
succinyl-CoA + glycine
Cavia porcellus
rate-limiting enzyme of heme biosynthesis
5-aminolevulinate + CoA + CO2
-
-
?
succinyl-CoA + glycine
Homo sapiens
rate-limiting enzyme of heme biosynthesis
5-aminolevulinate + CoA + CO2
-
Homo sapiens
?
succinyl-CoA + glycine
Rattus norvegicus
rate-limiting enzyme of heme biosynthesis
5-aminolevulinate + CoA + CO2
-
Rattus norvegicus
?
succinyl-CoA + glycine
Saccharomyces cerevisiae
rate-limiting enzyme of heme biosynthesis
5-aminolevulinate + CoA + CO2
-
-
?
succinyl-CoA + glycine
Oryctolagus cuniculus
rate-limiting enzyme of heme biosynthesis
5-aminolevulinate + CoA + CO2
-
-
?
succinyl-CoA + glycine
Rhodobacter sphaeroides
rate-limiting enzyme of heme biosynthesis
5-aminolevulinate + CoA + CO2
-
Rhodobacter sphaeroides
?
succinyl-CoA + glycine
Spinacia oleracea
rate-limiting enzyme of heme biosynthesis
5-aminolevulinate + CoA + CO2
-
-
?
succinyl-CoA + glycine
Propionibacterium freudenreichii subsp. shermanii
rate-limiting enzyme of heme biosynthesis
5-aminolevulinate + CoA + CO2
-
-
?
succinyl-CoA + glycine
Rhodospirillum rubrum
rate-limiting enzyme of heme biosynthesis
5-aminolevulinate + CoA + CO2
-
-
?
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Cavia porcellus
-
-
-
Gallus gallus
-
-
-
Homo sapiens
-
-
-
no activity in Chromatium sp.
-
-
-
Novispirillum itersonii
-
-
-
Oryctolagus cuniculus
-
-
-
Propionibacterium freudenreichii subsp. shermanii
-
-
-
Rattus norvegicus
-
-
-
Rhodobacter sphaeroides
-
enzyme exists in an inactive or low activity form which can under certain conditions become activated, spontaneous activation in presence of oxygen or an oxidizing agent shows a pH dependence with an optimum at about pH 7.0, assisted by 2-mercaptoethanol
-
Rhodospirillum rubrum
-
-
-
Saccharomyces cerevisiae
-
-
-
Spinacia oleracea
-
-
-
Purification (Commentary)
Commentary
Organism
-
Oryctolagus cuniculus
-
Rattus norvegicus
-
Rhodobacter sphaeroides
Reaction
Reaction
Commentary
Organism
succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2
mechanism
Cavia porcellus
succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2
mechanism
Oryctolagus cuniculus
succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2
mechanism
Propionibacterium freudenreichii subsp. shermanii
succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2
mechanism
Rhodospirillum rubrum
succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2
mechanism
Spinacia oleracea
succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2
mechanism
Rhodobacter sphaeroides
succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2
mechanism
Gallus gallus
succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2
mechanism
Homo sapiens
succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2
mechanism
Rattus norvegicus
succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2
mechanism
Saccharomyces cerevisiae
Source Tissue
Source Tissue
Commentary
Organism
Textmining
erythrocyte
-
Gallus gallus
-
erythrocyte
-
Homo sapiens
-
harderian gland
-
Rattus norvegicus
-
liver
-
Oryctolagus cuniculus
-
liver
-
Cavia porcellus
-
liver
-
Gallus gallus
-
liver
-
Homo sapiens
-
liver
-
Rattus norvegicus
-
reticulocyte
-
Oryctolagus cuniculus
-
reticulocyte
-
Rattus norvegicus
-
Specific Activity [micromol/min/mg]
Specific Activity Minimum [mol/min/mg]
Specific Activity Maximum [mol/min/mg]
Commentary
Organism
additional information
-
various tissues, overview
Gallus gallus
additional information
-
various tissues, overview
Homo sapiens
additional information
-
various tissues, overview
Novispirillum itersonii
additional information
-
various tissues, overview
Oryctolagus cuniculus
additional information
-
various tissues, overview
Propionibacterium freudenreichii subsp. shermanii
additional information
-
various tissues, overview
Rattus norvegicus
additional information
-
various tissues, overview
Rhodobacter sphaeroides
additional information
-
various tissues, overview
Rhodospirillum rubrum
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
acetyl-CoA + glycine
at 2% the rate of the reaction with succinyl-CoA
486820
Gallus gallus
?
-
-
-
?
acetyl-CoA + glycine
at 2% the rate of the reaction with succinyl-CoA
486820
Cavia porcellus
?
-
-
-
?
acetyl-CoA + glycine
at 2% the rate of the reaction with succinyl-CoA
486820
Homo sapiens
?
-
-
-
?
acetyl-CoA + glycine
at 2% the rate of the reaction with succinyl-CoA
486820
Rattus norvegicus
?
-
-
-
?
acetyl-CoA + glycine
at 2% the rate of the reaction with succinyl-CoA
486820
Saccharomyces cerevisiae
?
-
-
-
?
acetyl-CoA + glycine
at 2% the rate of the reaction with succinyl-CoA
486820
Oryctolagus cuniculus
?
-
-
-
?
acetyl-CoA + glycine
at 2% the rate of the reaction with succinyl-CoA
486820
Rhodobacter sphaeroides
?
-
-
-
?
acetyl-CoA + glycine
at 2% the rate of the reaction with succinyl-CoA
486820
Spinacia oleracea
?
-
-
-
?
acetyl-CoA + glycine
at 2% the rate of the reaction with succinyl-CoA
486820
Propionibacterium freudenreichii subsp. shermanii
?
-
-
-
?
acetyl-CoA + glycine
at 2% the rate of the reaction with succinyl-CoA
486820
Rhodospirillum rubrum
?
-
-
-
?
alpha-glutamyl-CoA + glycine
at 9% the rate of the reaction with succinyl-CoA
486820
Gallus gallus
6-amino-5-oxohexanoate + CoA + CO2
-
-
-
?
alpha-glutamyl-CoA + glycine
at 9% the rate of the reaction with succinyl-CoA
486820
Cavia porcellus
6-amino-5-oxohexanoate + CoA + CO2
-
-
-
?
alpha-glutamyl-CoA + glycine
at 9% the rate of the reaction with succinyl-CoA
486820
Homo sapiens
6-amino-5-oxohexanoate + CoA + CO2
-
-
-
?
alpha-glutamyl-CoA + glycine
at 9% the rate of the reaction with succinyl-CoA
486820
Rattus norvegicus
6-amino-5-oxohexanoate + CoA + CO2
-
-
-
?
alpha-glutamyl-CoA + glycine
at 9% the rate of the reaction with succinyl-CoA
486820
Saccharomyces cerevisiae
6-amino-5-oxohexanoate + CoA + CO2
-
-
-
?
alpha-glutamyl-CoA + glycine
at 9% the rate of the reaction with succinyl-CoA
486820
Oryctolagus cuniculus
6-amino-5-oxohexanoate + CoA + CO2
-
-
-
?
alpha-glutamyl-CoA + glycine
at 9% the rate of the reaction with succinyl-CoA
486820
Rhodobacter sphaeroides
6-amino-5-oxohexanoate + CoA + CO2
-
-
-
?
alpha-glutamyl-CoA + glycine
at 9% the rate of the reaction with succinyl-CoA
486820
Spinacia oleracea
6-amino-5-oxohexanoate + CoA + CO2
-
-
-
?
alpha-glutamyl-CoA + glycine
at 9% the rate of the reaction with succinyl-CoA
486820
Propionibacterium freudenreichii subsp. shermanii
6-amino-5-oxohexanoate + CoA + CO2
-
-
-
?
alpha-glutamyl-CoA + glycine
at 9% the rate of the reaction with succinyl-CoA
486820
Rhodospirillum rubrum
6-amino-5-oxohexanoate + CoA + CO2
-
-
-
?
succinyl-CoA + glycine
-
486820
Novispirillum itersonii
5-aminolevulinate + CoA + CO2
-
486820
Novispirillum itersonii
ir
succinyl-CoA + glycine
absolute requirement for glycine
486820
Gallus gallus
5-aminolevulinate + CoA + CO2
-
486820
Gallus gallus
ir
succinyl-CoA + glycine
absolute requirement for glycine
486820
Cavia porcellus
5-aminolevulinate + CoA + CO2
-
486820
Cavia porcellus
ir
succinyl-CoA + glycine
absolute requirement for glycine
486820
Homo sapiens
5-aminolevulinate + CoA + CO2
-
486820
Homo sapiens
ir
succinyl-CoA + glycine
absolute requirement for glycine
486820
Rattus norvegicus
5-aminolevulinate + CoA + CO2
-
486820
Rattus norvegicus
ir
succinyl-CoA + glycine
absolute requirement for glycine
486820
Saccharomyces cerevisiae
5-aminolevulinate + CoA + CO2
-
486820
Saccharomyces cerevisiae
ir
succinyl-CoA + glycine
absolute requirement for glycine
486820
Oryctolagus cuniculus
5-aminolevulinate + CoA + CO2
-
486820
Oryctolagus cuniculus
ir
succinyl-CoA + glycine
absolute requirement for glycine
486820
Rhodobacter sphaeroides
5-aminolevulinate + CoA + CO2
-
486820
Rhodobacter sphaeroides
ir
succinyl-CoA + glycine
absolute requirement for glycine
486820
Spinacia oleracea
5-aminolevulinate + CoA + CO2
-
486820
Spinacia oleracea
ir
succinyl-CoA + glycine
absolute requirement for glycine
486820
Propionibacterium freudenreichii subsp. shermanii
5-aminolevulinate + CoA + CO2
-
486820
Propionibacterium freudenreichii subsp. shermanii
ir
succinyl-CoA + glycine
absolute requirement for glycine
486820
Rhodospirillum rubrum
5-aminolevulinate + CoA + CO2
-
486820
Rhodospirillum rubrum
ir
succinyl-CoA + glycine
key enzyme in tetrapyrrole biosynthesis
486820
Gallus gallus
5-aminolevulinate + CoA + CO2
-
486820
Gallus gallus
?
succinyl-CoA + glycine
key enzyme in tetrapyrrole biosynthesis
486820
Cavia porcellus
5-aminolevulinate + CoA + CO2
-
-
-
?
succinyl-CoA + glycine
key enzyme in tetrapyrrole biosynthesis
486820
Homo sapiens
5-aminolevulinate + CoA + CO2
-
486820
Homo sapiens
?
succinyl-CoA + glycine
key enzyme in tetrapyrrole biosynthesis
486820
Rattus norvegicus
5-aminolevulinate + CoA + CO2
-
486820
Rattus norvegicus
?
succinyl-CoA + glycine
key enzyme in tetrapyrrole biosynthesis
486820
Saccharomyces cerevisiae
5-aminolevulinate + CoA + CO2
-
-
-
?
succinyl-CoA + glycine
key enzyme in tetrapyrrole biosynthesis
486820
Oryctolagus cuniculus
5-aminolevulinate + CoA + CO2
-
-
-
?
succinyl-CoA + glycine
key enzyme in tetrapyrrole biosynthesis
486820
Rhodobacter sphaeroides
5-aminolevulinate + CoA + CO2
-
486820
Rhodobacter sphaeroides
?
succinyl-CoA + glycine
key enzyme in tetrapyrrole biosynthesis
486820
Spinacia oleracea
5-aminolevulinate + CoA + CO2
-
-
-
?
succinyl-CoA + glycine
key enzyme in tetrapyrrole biosynthesis
486820
Propionibacterium freudenreichii subsp. shermanii
5-aminolevulinate + CoA + CO2
-
-
-
?
succinyl-CoA + glycine
key enzyme in tetrapyrrole biosynthesis
486820
Rhodospirillum rubrum
5-aminolevulinate + CoA + CO2
-
-
-
?
succinyl-CoA + glycine
key enzyme in tetrapyrrole biosynthesis
486820
Novispirillum itersonii
5-aminolevulinate + CoA + CO2
-
-
-
?
succinyl-CoA + glycine
rate-limiting enzyme of heme biosynthesis
486820
Gallus gallus
5-aminolevulinate + CoA + CO2
-
486820
Gallus gallus
?
succinyl-CoA + glycine
rate-limiting enzyme of heme biosynthesis
486820
Cavia porcellus
5-aminolevulinate + CoA + CO2
-
-
-
?
succinyl-CoA + glycine
rate-limiting enzyme of heme biosynthesis
486820
Homo sapiens
5-aminolevulinate + CoA + CO2
-
486820
Homo sapiens
?
succinyl-CoA + glycine
rate-limiting enzyme of heme biosynthesis
486820
Rattus norvegicus
5-aminolevulinate + CoA + CO2
-
486820
Rattus norvegicus
?
succinyl-CoA + glycine
rate-limiting enzyme of heme biosynthesis
486820
Saccharomyces cerevisiae
5-aminolevulinate + CoA + CO2
-
-
-
?
succinyl-CoA + glycine
rate-limiting enzyme of heme biosynthesis
486820
Oryctolagus cuniculus
5-aminolevulinate + CoA + CO2
-
-
-
?
succinyl-CoA + glycine
rate-limiting enzyme of heme biosynthesis
486820
Rhodobacter sphaeroides
5-aminolevulinate + CoA + CO2
-
486820
Rhodobacter sphaeroides
?
succinyl-CoA + glycine
rate-limiting enzyme of heme biosynthesis
486820
Spinacia oleracea
5-aminolevulinate + CoA + CO2
-
-
-
?
succinyl-CoA + glycine
rate-limiting enzyme of heme biosynthesis
486820
Propionibacterium freudenreichii subsp. shermanii
5-aminolevulinate + CoA + CO2
-
-
-
?
succinyl-CoA + glycine
rate-limiting enzyme of heme biosynthesis
486820
Rhodospirillum rubrum
5-aminolevulinate + CoA + CO2
-
-
-
?
succinyl-CoA-monomethyl ester + glycine
at 80% the rate of the reaction with succinyl-CoA
486820
Gallus gallus
5-aminolevulinic acid methyl ester + CoA + CO2
-
-
-
-
succinyl-CoA-monomethyl ester + glycine
at 80% the rate of the reaction with succinyl-CoA
486820
Cavia porcellus
5-aminolevulinic acid methyl ester + CoA + CO2
-
-
-
-
succinyl-CoA-monomethyl ester + glycine
at 80% the rate of the reaction with succinyl-CoA
486820
Homo sapiens
5-aminolevulinic acid methyl ester + CoA + CO2
-
-
-
-
succinyl-CoA-monomethyl ester + glycine
at 80% the rate of the reaction with succinyl-CoA
486820
Rattus norvegicus
5-aminolevulinic acid methyl ester + CoA + CO2
-
-
-
-
succinyl-CoA-monomethyl ester + glycine
at 80% the rate of the reaction with succinyl-CoA
486820
Saccharomyces cerevisiae
5-aminolevulinic acid methyl ester + CoA + CO2
-
-
-
-
succinyl-CoA-monomethyl ester + glycine
at 80% the rate of the reaction with succinyl-CoA
486820
Oryctolagus cuniculus
5-aminolevulinic acid methyl ester + CoA + CO2
-
-
-
-
succinyl-CoA-monomethyl ester + glycine
at 80% the rate of the reaction with succinyl-CoA
486820
Rhodobacter sphaeroides
5-aminolevulinic acid methyl ester + CoA + CO2
-
-
-
-
succinyl-CoA-monomethyl ester + glycine
at 80% the rate of the reaction with succinyl-CoA
486820
Spinacia oleracea
5-aminolevulinic acid methyl ester + CoA + CO2
-
-
-
-
succinyl-CoA-monomethyl ester + glycine
at 80% the rate of the reaction with succinyl-CoA
486820
Propionibacterium freudenreichii subsp. shermanii
5-aminolevulinic acid methyl ester + CoA + CO2
-
-
-
-
succinyl-CoA-monomethyl ester + glycine
at 80% the rate of the reaction with succinyl-CoA
486820
Rhodospirillum rubrum
5-aminolevulinic acid methyl ester + CoA + CO2
-
-
-
-
Temperature Stability [C]
Temperature Stability Minimum [C]
Temperature Stability Maximum [C]
Commentary
Organism
additional information
-
-
Rattus norvegicus
additional information
-
temperature insensitive
Rhodobacter sphaeroides
Cofactor
Cofactor
Commentary
Organism
Structure
pyridoxal 5'-phosphate
-
Novispirillum itersonii
pyridoxal 5'-phosphate
-
Propionibacterium freudenreichii subsp. shermanii
pyridoxal 5'-phosphate
-
Rhodospirillum rubrum
pyridoxal 5'-phosphate
-
Spinacia oleracea
pyridoxal 5'-phosphate
bound to the enzyme through a Schiff base linkage
Rhodobacter sphaeroides
pyridoxal 5'-phosphate
-
Oryctolagus cuniculus
pyridoxal 5'-phosphate
-
Gallus gallus
pyridoxal 5'-phosphate
-
Cavia porcellus
pyridoxal 5'-phosphate
-
Rattus norvegicus
pyridoxal 5'-phosphate
-
Saccharomyces cerevisiae
pyridoxal 5'-phosphate
-
Homo sapiens
Activating Compound (protein specific)
Activating Compound
Commentary
Organism
Structure
2-allyl-2-isopropylacetamide
strong induction of enzyme in liver
Cavia porcellus
2-allyl-2-isopropylacetamide
strong induction of enzyme in liver
Gallus gallus
2-allyl-2-isopropylacetamide
strong induction of enzyme in liver
Rattus norvegicus
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
pyridoxal 5'-phosphate
-
Novispirillum itersonii
pyridoxal 5'-phosphate
-
Propionibacterium freudenreichii subsp. shermanii
pyridoxal 5'-phosphate
-
Rhodospirillum rubrum
pyridoxal 5'-phosphate
-
Spinacia oleracea
pyridoxal 5'-phosphate
bound to the enzyme through a Schiff base linkage
Rhodobacter sphaeroides
pyridoxal 5'-phosphate
-
Oryctolagus cuniculus
pyridoxal 5'-phosphate
-
Gallus gallus
pyridoxal 5'-phosphate
-
Cavia porcellus
pyridoxal 5'-phosphate
-
Rattus norvegicus
pyridoxal 5'-phosphate
-
Saccharomyces cerevisiae
pyridoxal 5'-phosphate
-
Homo sapiens
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
2-hydroxyethyldisulfide
-
Rhodobacter sphaeroides
2-mercaptoethanol
-
Oryctolagus cuniculus
2-oxoglutarate
-
Cavia porcellus
2-oxoglutarate
-
Gallus gallus
2-oxoglutarate
-
Homo sapiens
2-oxoglutarate
-
Oryctolagus cuniculus
2-oxoglutarate
-
Propionibacterium freudenreichii subsp. shermanii
2-oxoglutarate
-
Rattus norvegicus
2-oxoglutarate
-
Rhodobacter sphaeroides
2-oxoglutarate
-
Rhodospirillum rubrum
2-oxoglutarate
-
Saccharomyces cerevisiae
2-oxoglutarate
-
Spinacia oleracea
aminomalonate
-
Gallus gallus
aminomalonate
-
Rhodobacter sphaeroides
Aminomethylphosphonate
-
Cavia porcellus
Aminomethylphosphonate
-
Gallus gallus
Aminomethylphosphonate
-
Homo sapiens
Aminomethylphosphonate
-
Oryctolagus cuniculus
Aminomethylphosphonate
-
Propionibacterium freudenreichii subsp. shermanii
Aminomethylphosphonate
-
Rattus norvegicus
Aminomethylphosphonate
-
Rhodospirillum rubrum
Aminomethylphosphonate
-
Saccharomyces cerevisiae
Aminomethylphosphonate
-
Spinacia oleracea
Aminomethylphosphonate
-
Rhodobacter sphaeroides
beta-Alanine
-
Gallus gallus
beta-Alanine
-
Rhodobacter sphaeroides
Borohydride
in presence of pyridoxal 5'-phosphate
Rhodobacter sphaeroides
Cu2+
-
Rhodobacter sphaeroides
Cu2+
-
Rhodospirillum rubrum
cyanide
-
Gallus gallus
Diethyl aminomalonate
-
Gallus gallus
Diethyl aminomalonate
-
Rhodobacter sphaeroides
ethanolamine
-
Gallus gallus
ethanolamine
-
Rhodobacter sphaeroides
ethanolamine
-
Rhodospirillum rubrum
Fe2+
-
Rhodobacter sphaeroides
Fe3+
-
Oryctolagus cuniculus
Fe3+
no inhibition
Rhodobacter sphaeroides
ferroheme
-
Cavia porcellus
ferroheme
-
Gallus gallus
ferroheme
-
Homo sapiens
ferroheme
-
Oryctolagus cuniculus
ferroheme
-
Propionibacterium freudenreichii subsp. shermanii
ferroheme
-
Rattus norvegicus
ferroheme
-
Rhodobacter sphaeroides
ferroheme
-
Rhodospirillum rubrum
ferroheme
-
Saccharomyces cerevisiae
ferroheme
-
Spinacia oleracea
glutathione
-
Oryctolagus cuniculus
hemin
-
Homo sapiens
hemin
-
Oryctolagus cuniculus
hemin
-
Propionibacterium freudenreichii subsp. shermanii
hemin
-
Rattus norvegicus
hemin
-
Rhodospirillum rubrum
hemin
-
Spinacia oleracea
hemin
-
Gallus gallus
hemin
-
Saccharomyces cerevisiae
hemin
-
Cavia porcellus
hemin
-
Rhodobacter sphaeroides
hemoglobin
-
Cavia porcellus
hemoglobin
-
Gallus gallus
hemoglobin
-
Homo sapiens
hemoglobin
-
Oryctolagus cuniculus
hemoglobin
-
Propionibacterium freudenreichii subsp. shermanii
hemoglobin
-
Rattus norvegicus
hemoglobin
-
Rhodobacter sphaeroides
hemoglobin
-
Rhodospirillum rubrum
hemoglobin
-
Saccharomyces cerevisiae
hemoglobin
-
Spinacia oleracea
iodoacetamide
-
Rhodobacter sphaeroides
Isobutylamine
-
Gallus gallus
Isobutylamine
-
Rhodobacter sphaeroides
L-alanine
-
Gallus gallus
L-alanine
-
Rhodobacter sphaeroides
L-cysteine
-
Gallus gallus
L-Penicillamine
-
Gallus gallus
L-threonine
-
Gallus gallus
L-threonine
-
Rhodobacter sphaeroides
metalloporphyrins
containing Co2+, Zn2+ or Mg2+
Cavia porcellus
metalloporphyrins
containing Co2+, Zn2+ or Mg2+
Gallus gallus
metalloporphyrins
containing Co2+, Zn2+ or Mg2+
Homo sapiens
metalloporphyrins
containing Co2+, Zn2+ or Mg2+
Oryctolagus cuniculus
metalloporphyrins
containing Co2+, Zn2+ or Mg2+
Propionibacterium freudenreichii subsp. shermanii
metalloporphyrins
containing Co2+, Zn2+ or Mg2+
Rattus norvegicus
metalloporphyrins
containing Co2+, Zn2+ or Mg2+
Rhodobacter sphaeroides
metalloporphyrins
containing Co2+, Zn2+ or Mg2+
Rhodospirillum rubrum
metalloporphyrins
containing Co2+, Zn2+ or Mg2+
Saccharomyces cerevisiae
metalloporphyrins
containing Co2+, Zn2+ or Mg2+
Spinacia oleracea
myoglobin
-
Cavia porcellus
myoglobin
-
Gallus gallus
myoglobin
-
Homo sapiens
myoglobin
-
Oryctolagus cuniculus
myoglobin
-
Propionibacterium freudenreichii subsp. shermanii
myoglobin
-
Rattus norvegicus
myoglobin
-
Rhodobacter sphaeroides
myoglobin
-
Rhodospirillum rubrum
myoglobin
-
Saccharomyces cerevisiae
myoglobin
-
Spinacia oleracea
p-mercuribenzoate
-
Gallus gallus
p-mercuribenzoate
-
Rhodobacter sphaeroides
pyruvate
-
Cavia porcellus
pyruvate
-
Gallus gallus
pyruvate
-
Homo sapiens
pyruvate
-
Oryctolagus cuniculus
pyruvate
-
Propionibacterium freudenreichii subsp. shermanii
pyruvate
-
Rattus norvegicus
pyruvate
-
Rhodobacter sphaeroides
pyruvate
-
Rhodospirillum rubrum
pyruvate
-
Saccharomyces cerevisiae
pyruvate
-
Spinacia oleracea
KM Value [mM] (protein specific)
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
additional information
-
additional information
-
Cavia porcellus
additional information
-
additional information
overview
Gallus gallus
additional information
-
additional information
-
Homo sapiens
additional information
-
additional information
overview
Oryctolagus cuniculus
additional information
-
additional information
-
Propionibacterium freudenreichii subsp. shermanii
additional information
-
additional information
overview
Rattus norvegicus
additional information
-
additional information
overview
Rhodobacter sphaeroides
additional information
-
additional information
-
Saccharomyces cerevisiae
additional information
-
additional information
-
Spinacia oleracea
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
microsome
-
Cavia porcellus
-
-
microsome
-
Homo sapiens
-
-
microsome
-
Oryctolagus cuniculus
-
-
microsome
-
Rattus norvegicus
-
-
mitochondrion
-
Oryctolagus cuniculus
5739
-
mitochondrion
-
Cavia porcellus
5739
-
mitochondrion
-
Gallus gallus
5739
-
mitochondrion
-
Rattus norvegicus
5739
-
mitochondrion
-
Homo sapiens
5739
-
additional information
synthesized in microsomes and then migrates to the mitochondria
Cavia porcellus
-
-
additional information
synthesized in microsomes and then migrates to the mitochondria
Homo sapiens
-
-
additional information
synthesized in microsomes and then migrates to the mitochondria
Oryctolagus cuniculus
-
-
additional information
synthesized in microsomes and then migrates to the mitochondria
Rattus norvegicus
-
-
Molecular Weight [Da] (protein specific)
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
additional information
-
-
Gallus gallus
additional information
-
-
Homo sapiens
additional information
-
-
Rattus norvegicus
additional information
-
-
Rhodobacter sphaeroides
200000
-
gel filtration
Oryctolagus cuniculus
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
succinyl-CoA + glycine
Gallus gallus
key enzyme in tetrapyrrole biosynthesis
5-aminolevulinate + CoA + CO2
-
Gallus gallus
?
succinyl-CoA + glycine
Cavia porcellus
key enzyme in tetrapyrrole biosynthesis
5-aminolevulinate + CoA + CO2
-
-
?
succinyl-CoA + glycine
Homo sapiens
key enzyme in tetrapyrrole biosynthesis
5-aminolevulinate + CoA + CO2
-
Homo sapiens
?
succinyl-CoA + glycine
Rattus norvegicus
key enzyme in tetrapyrrole biosynthesis
5-aminolevulinate + CoA + CO2
-
Rattus norvegicus
?
succinyl-CoA + glycine
Saccharomyces cerevisiae
key enzyme in tetrapyrrole biosynthesis
5-aminolevulinate + CoA + CO2
-
-
?
succinyl-CoA + glycine
Oryctolagus cuniculus
key enzyme in tetrapyrrole biosynthesis
5-aminolevulinate + CoA + CO2
-
-
?
succinyl-CoA + glycine
Rhodobacter sphaeroides
key enzyme in tetrapyrrole biosynthesis
5-aminolevulinate + CoA + CO2
-
Rhodobacter sphaeroides
?
succinyl-CoA + glycine
Spinacia oleracea
key enzyme in tetrapyrrole biosynthesis
5-aminolevulinate + CoA + CO2
-
-
?
succinyl-CoA + glycine
Propionibacterium freudenreichii subsp. shermanii
key enzyme in tetrapyrrole biosynthesis
5-aminolevulinate + CoA + CO2
-
-
?
succinyl-CoA + glycine
Rhodospirillum rubrum
key enzyme in tetrapyrrole biosynthesis
5-aminolevulinate + CoA + CO2
-
-
?
succinyl-CoA + glycine
Novispirillum itersonii
key enzyme in tetrapyrrole biosynthesis
5-aminolevulinate + CoA + CO2
-
-
?
succinyl-CoA + glycine
Gallus gallus
rate-limiting enzyme of heme biosynthesis
5-aminolevulinate + CoA + CO2
-
Gallus gallus
?
succinyl-CoA + glycine
Cavia porcellus
rate-limiting enzyme of heme biosynthesis
5-aminolevulinate + CoA + CO2
-
-
?
succinyl-CoA + glycine
Homo sapiens
rate-limiting enzyme of heme biosynthesis
5-aminolevulinate + CoA + CO2
-
Homo sapiens
?
succinyl-CoA + glycine
Rattus norvegicus
rate-limiting enzyme of heme biosynthesis
5-aminolevulinate + CoA + CO2
-
Rattus norvegicus
?
succinyl-CoA + glycine
Saccharomyces cerevisiae
rate-limiting enzyme of heme biosynthesis
5-aminolevulinate + CoA + CO2
-
-
?
succinyl-CoA + glycine
Oryctolagus cuniculus
rate-limiting enzyme of heme biosynthesis
5-aminolevulinate + CoA + CO2
-
-
?
succinyl-CoA + glycine
Rhodobacter sphaeroides
rate-limiting enzyme of heme biosynthesis
5-aminolevulinate + CoA + CO2
-
Rhodobacter sphaeroides
?
succinyl-CoA + glycine
Spinacia oleracea
rate-limiting enzyme of heme biosynthesis
5-aminolevulinate + CoA + CO2
-
-
?
succinyl-CoA + glycine
Propionibacterium freudenreichii subsp. shermanii
rate-limiting enzyme of heme biosynthesis
5-aminolevulinate + CoA + CO2
-
-
?
succinyl-CoA + glycine
Rhodospirillum rubrum
rate-limiting enzyme of heme biosynthesis
5-aminolevulinate + CoA + CO2
-
-
?
Purification (Commentary) (protein specific)
Commentary
Organism
-
Oryctolagus cuniculus
-
Rattus norvegicus
-
Rhodobacter sphaeroides
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
erythrocyte
-
Gallus gallus
-
erythrocyte
-
Homo sapiens
-
harderian gland
-
Rattus norvegicus
-
liver
-
Oryctolagus cuniculus
-
liver
-
Cavia porcellus
-
liver
-
Gallus gallus
-
liver
-
Homo sapiens
-
liver
-
Rattus norvegicus
-
reticulocyte
-
Oryctolagus cuniculus
-
reticulocyte
-
Rattus norvegicus
-
Specific Activity [micromol/min/mg] (protein specific)
Specific Activity Minimum [mol/min/mg]
Specific Activity Maximum [mol/min/mg]
Commentary
Organism
additional information
-
various tissues, overview
Gallus gallus
additional information
-
various tissues, overview
Homo sapiens
additional information
-
various tissues, overview
Novispirillum itersonii
additional information
-
various tissues, overview
Oryctolagus cuniculus
additional information
-
various tissues, overview
Propionibacterium freudenreichii subsp. shermanii
additional information
-
various tissues, overview
Rattus norvegicus
additional information
-
various tissues, overview
Rhodobacter sphaeroides
additional information
-
various tissues, overview
Rhodospirillum rubrum
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
acetyl-CoA + glycine
at 2% the rate of the reaction with succinyl-CoA
486820
Gallus gallus
?
-
-
-
?
acetyl-CoA + glycine
at 2% the rate of the reaction with succinyl-CoA
486820
Cavia porcellus
?
-
-
-
?
acetyl-CoA + glycine
at 2% the rate of the reaction with succinyl-CoA
486820
Homo sapiens
?
-
-
-
?
acetyl-CoA + glycine
at 2% the rate of the reaction with succinyl-CoA
486820
Rattus norvegicus
?
-
-
-
?
acetyl-CoA + glycine
at 2% the rate of the reaction with succinyl-CoA
486820
Saccharomyces cerevisiae
?
-
-
-
?
acetyl-CoA + glycine
at 2% the rate of the reaction with succinyl-CoA
486820
Oryctolagus cuniculus
?
-
-
-
?
acetyl-CoA + glycine
at 2% the rate of the reaction with succinyl-CoA
486820
Rhodobacter sphaeroides
?
-
-
-
?
acetyl-CoA + glycine
at 2% the rate of the reaction with succinyl-CoA
486820
Spinacia oleracea
?
-
-
-
?
acetyl-CoA + glycine
at 2% the rate of the reaction with succinyl-CoA
486820
Propionibacterium freudenreichii subsp. shermanii
?
-
-
-
?
acetyl-CoA + glycine
at 2% the rate of the reaction with succinyl-CoA
486820
Rhodospirillum rubrum
?
-
-
-
?
alpha-glutamyl-CoA + glycine
at 9% the rate of the reaction with succinyl-CoA
486820
Gallus gallus
6-amino-5-oxohexanoate + CoA + CO2
-
-
-
?
alpha-glutamyl-CoA + glycine
at 9% the rate of the reaction with succinyl-CoA
486820
Cavia porcellus
6-amino-5-oxohexanoate + CoA + CO2
-
-
-
?
alpha-glutamyl-CoA + glycine
at 9% the rate of the reaction with succinyl-CoA
486820
Homo sapiens
6-amino-5-oxohexanoate + CoA + CO2
-
-
-
?
alpha-glutamyl-CoA + glycine
at 9% the rate of the reaction with succinyl-CoA
486820
Rattus norvegicus
6-amino-5-oxohexanoate + CoA + CO2
-
-
-
?
alpha-glutamyl-CoA + glycine
at 9% the rate of the reaction with succinyl-CoA
486820
Saccharomyces cerevisiae
6-amino-5-oxohexanoate + CoA + CO2
-
-
-
?
alpha-glutamyl-CoA + glycine
at 9% the rate of the reaction with succinyl-CoA
486820
Oryctolagus cuniculus
6-amino-5-oxohexanoate + CoA + CO2
-
-
-
?
alpha-glutamyl-CoA + glycine
at 9% the rate of the reaction with succinyl-CoA
486820
Rhodobacter sphaeroides
6-amino-5-oxohexanoate + CoA + CO2
-
-
-
?
alpha-glutamyl-CoA + glycine
at 9% the rate of the reaction with succinyl-CoA
486820
Spinacia oleracea
6-amino-5-oxohexanoate + CoA + CO2
-
-
-
?
alpha-glutamyl-CoA + glycine
at 9% the rate of the reaction with succinyl-CoA
486820
Propionibacterium freudenreichii subsp. shermanii
6-amino-5-oxohexanoate + CoA + CO2
-
-
-
?
alpha-glutamyl-CoA + glycine
at 9% the rate of the reaction with succinyl-CoA
486820
Rhodospirillum rubrum
6-amino-5-oxohexanoate + CoA + CO2
-
-
-
?
succinyl-CoA + glycine
-
486820
Novispirillum itersonii
5-aminolevulinate + CoA + CO2
-
486820
Novispirillum itersonii
ir
succinyl-CoA + glycine
absolute requirement for glycine
486820
Gallus gallus
5-aminolevulinate + CoA + CO2
-
486820
Gallus gallus
ir
succinyl-CoA + glycine
absolute requirement for glycine
486820
Cavia porcellus
5-aminolevulinate + CoA + CO2
-
486820
Cavia porcellus
ir
succinyl-CoA + glycine
absolute requirement for glycine
486820
Homo sapiens
5-aminolevulinate + CoA + CO2
-
486820
Homo sapiens
ir
succinyl-CoA + glycine
absolute requirement for glycine
486820
Rattus norvegicus
5-aminolevulinate + CoA + CO2
-
486820
Rattus norvegicus
ir
succinyl-CoA + glycine
absolute requirement for glycine
486820
Saccharomyces cerevisiae
5-aminolevulinate + CoA + CO2
-
486820
Saccharomyces cerevisiae
ir
succinyl-CoA + glycine
absolute requirement for glycine
486820
Oryctolagus cuniculus
5-aminolevulinate + CoA + CO2
-
486820
Oryctolagus cuniculus
ir
succinyl-CoA + glycine
absolute requirement for glycine
486820
Rhodobacter sphaeroides
5-aminolevulinate + CoA + CO2
-
486820
Rhodobacter sphaeroides
ir
succinyl-CoA + glycine
absolute requirement for glycine
486820
Spinacia oleracea
5-aminolevulinate + CoA + CO2
-
486820
Spinacia oleracea
ir
succinyl-CoA + glycine
absolute requirement for glycine
486820
Propionibacterium freudenreichii subsp. shermanii
5-aminolevulinate + CoA + CO2
-
486820
Propionibacterium freudenreichii subsp. shermanii
ir
succinyl-CoA + glycine
absolute requirement for glycine
486820
Rhodospirillum rubrum
5-aminolevulinate + CoA + CO2
-
486820
Rhodospirillum rubrum
ir
succinyl-CoA + glycine
key enzyme in tetrapyrrole biosynthesis
486820
Gallus gallus
5-aminolevulinate + CoA + CO2
-
486820
Gallus gallus
?
succinyl-CoA + glycine
key enzyme in tetrapyrrole biosynthesis
486820
Cavia porcellus
5-aminolevulinate + CoA + CO2
-
-
-
?
succinyl-CoA + glycine
key enzyme in tetrapyrrole biosynthesis
486820
Homo sapiens
5-aminolevulinate + CoA + CO2
-
486820
Homo sapiens
?
succinyl-CoA + glycine
key enzyme in tetrapyrrole biosynthesis
486820
Rattus norvegicus
5-aminolevulinate + CoA + CO2
-
486820
Rattus norvegicus
?
succinyl-CoA + glycine
key enzyme in tetrapyrrole biosynthesis
486820
Saccharomyces cerevisiae
5-aminolevulinate + CoA + CO2
-
-
-
?
succinyl-CoA + glycine
key enzyme in tetrapyrrole biosynthesis
486820
Oryctolagus cuniculus
5-aminolevulinate + CoA + CO2
-
-
-
?
succinyl-CoA + glycine
key enzyme in tetrapyrrole biosynthesis
486820
Rhodobacter sphaeroides
5-aminolevulinate + CoA + CO2
-
486820
Rhodobacter sphaeroides
?
succinyl-CoA + glycine
key enzyme in tetrapyrrole biosynthesis
486820
Spinacia oleracea
5-aminolevulinate + CoA + CO2
-
-
-
?
succinyl-CoA + glycine
key enzyme in tetrapyrrole biosynthesis
486820
Propionibacterium freudenreichii subsp. shermanii
5-aminolevulinate + CoA + CO2
-
-
-
?
succinyl-CoA + glycine
key enzyme in tetrapyrrole biosynthesis
486820
Rhodospirillum rubrum
5-aminolevulinate + CoA + CO2
-
-
-
?
succinyl-CoA + glycine
key enzyme in tetrapyrrole biosynthesis
486820
Novispirillum itersonii
5-aminolevulinate + CoA + CO2
-
-
-
?
succinyl-CoA + glycine
rate-limiting enzyme of heme biosynthesis
486820
Gallus gallus
5-aminolevulinate + CoA + CO2
-
486820
Gallus gallus
?
succinyl-CoA + glycine
rate-limiting enzyme of heme biosynthesis
486820
Cavia porcellus
5-aminolevulinate + CoA + CO2
-
-
-
?
succinyl-CoA + glycine
rate-limiting enzyme of heme biosynthesis
486820
Homo sapiens
5-aminolevulinate + CoA + CO2
-
486820
Homo sapiens
?
succinyl-CoA + glycine
rate-limiting enzyme of heme biosynthesis
486820
Rattus norvegicus
5-aminolevulinate + CoA + CO2
-
486820
Rattus norvegicus
?
succinyl-CoA + glycine
rate-limiting enzyme of heme biosynthesis
486820
Saccharomyces cerevisiae
5-aminolevulinate + CoA + CO2
-
-
-
?
succinyl-CoA + glycine
rate-limiting enzyme of heme biosynthesis
486820
Oryctolagus cuniculus
5-aminolevulinate + CoA + CO2
-
-
-
?
succinyl-CoA + glycine
rate-limiting enzyme of heme biosynthesis
486820
Rhodobacter sphaeroides
5-aminolevulinate + CoA + CO2
-
486820
Rhodobacter sphaeroides
?
succinyl-CoA + glycine
rate-limiting enzyme of heme biosynthesis
486820
Spinacia oleracea
5-aminolevulinate + CoA + CO2
-
-
-
?
succinyl-CoA + glycine
rate-limiting enzyme of heme biosynthesis
486820
Propionibacterium freudenreichii subsp. shermanii
5-aminolevulinate + CoA + CO2
-
-
-
?
succinyl-CoA + glycine
rate-limiting enzyme of heme biosynthesis
486820
Rhodospirillum rubrum
5-aminolevulinate + CoA + CO2
-
-
-
?
succinyl-CoA-monomethyl ester + glycine
at 80% the rate of the reaction with succinyl-CoA
486820
Gallus gallus
5-aminolevulinic acid methyl ester + CoA + CO2
-
-
-
-
succinyl-CoA-monomethyl ester + glycine
at 80% the rate of the reaction with succinyl-CoA
486820
Cavia porcellus
5-aminolevulinic acid methyl ester + CoA + CO2
-
-
-
-
succinyl-CoA-monomethyl ester + glycine
at 80% the rate of the reaction with succinyl-CoA
486820
Homo sapiens
5-aminolevulinic acid methyl ester + CoA + CO2
-
-
-
-
succinyl-CoA-monomethyl ester + glycine
at 80% the rate of the reaction with succinyl-CoA
486820
Rattus norvegicus
5-aminolevulinic acid methyl ester + CoA + CO2
-
-
-
-
succinyl-CoA-monomethyl ester + glycine
at 80% the rate of the reaction with succinyl-CoA
486820
Saccharomyces cerevisiae
5-aminolevulinic acid methyl ester + CoA + CO2
-
-
-
-
succinyl-CoA-monomethyl ester + glycine
at 80% the rate of the reaction with succinyl-CoA
486820
Oryctolagus cuniculus
5-aminolevulinic acid methyl ester + CoA + CO2
-
-
-
-
succinyl-CoA-monomethyl ester + glycine
at 80% the rate of the reaction with succinyl-CoA
486820
Rhodobacter sphaeroides
5-aminolevulinic acid methyl ester + CoA + CO2
-
-
-
-
succinyl-CoA-monomethyl ester + glycine
at 80% the rate of the reaction with succinyl-CoA
486820
Spinacia oleracea
5-aminolevulinic acid methyl ester + CoA + CO2
-
-
-
-
succinyl-CoA-monomethyl ester + glycine
at 80% the rate of the reaction with succinyl-CoA
486820
Propionibacterium freudenreichii subsp. shermanii
5-aminolevulinic acid methyl ester + CoA + CO2
-
-
-
-
succinyl-CoA-monomethyl ester + glycine
at 80% the rate of the reaction with succinyl-CoA
486820
Rhodospirillum rubrum
5-aminolevulinic acid methyl ester + CoA + CO2
-
-
-
-
Temperature Stability [C] (protein specific)
Temperature Stability Minimum [C]
Temperature Stability Maximum [C]
Commentary
Organism
additional information
-
-
Rattus norvegicus
additional information
-
temperature insensitive
Rhodobacter sphaeroides
Other publictions for EC 2.3.1.37
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [C]
Temperature Range [C]
Temperature Stability [C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [C] (protein specific)
Temperature Range [C] (protein specific)
Temperature Stability [C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
735604
Ogawa-Otomo
Aminolevulinate synthase 2 med ...
Xenopus laevis
Biochem. Biophys. Res. Commun.
456
476-481
2015
-
-
1
-
-
-
-
-
-
-
-
-
-
4
-
-
-
-
-
6
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
6
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
735684
Fratz
Human erythroid 5-aminolevulin ...
Homo sapiens
Biochemistry
54
5617-5631
2015
-
-
1
-
2
-
-
1
1
-
-
1
-
3
-
-
-
-
-
1
-
-
1
1
-
-
1
-
-
-
-
1
-
-
-
-
-
1
1
-
2
-
-
-
-
1
1
-
-
1
-
-
-
-
-
1
-
-
1
1
-
-
1
-
-
-
-
-
-
5
5
-
-
-
736116
Stojanovski
Murine erythroid 5-aminolevuli ...
Mus musculus
FEBS open bio
5
824-831
2015
-
-
1
-
1
-
-
5
-
-
-
1
-
4
-
-
1
1
-
-
-
-
2
1
1
-
-
2
1
-
-
1
-
-
-
-
-
1
1
-
1
-
-
-
-
5
-
-
-
1
-
-
-
1
-
-
-
-
2
1
1
-
-
2
1
-
-
-
-
2
2
-
2
2
736491
Stojanovski
Asn-150 of murine erythroid 5- ...
Mus musculus
J. Biol. Chem.
290
30750-30761
2015
-
-
1
-
6
-
-
12
-
-
-
1
-
3
-
-
1
1
-
-
-
-
2
-
1
-
-
6
1
-
-
1
-
-
-
-
-
1
1
-
6
-
-
-
-
12
-
-
-
1
-
-
-
1
-
-
-
-
2
-
1
-
-
6
1
-
-
-
-
2
2
-
12
12
735711
Stojanovski
Catalytically active alkaline ...
Mus musculus
Biochim. Biophys. Acta
1844
2145-2154
2014
-
-
-
-
-
-
-
1
-
-
-
1
-
2
-
-
-
-
-
-
-
-
1
-
1
-
1
-
1
2
1
1
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
1
-
-
-
-
-
-
-
-
1
-
1
-
1
-
1
2
1
-
-
1
1
-
-
-
736454
Stojanovski
Unstable reaction intermediate ...
Mus musculus
J. Biol. Chem.
289
22915-22925
2014
-
-
-
-
1
-
-
1
-
-
-
1
-
3
-
-
-
1
-
-
-
-
4
-
1
-
-
-
1
-
-
1
-
-
-
-
-
-
1
-
1
-
-
-
-
1
-
-
-
1
-
-
-
-
-
-
-
-
4
-
1
-
-
-
1
-
-
-
-
1
1
-
-
-
737145
Fratz
Expression of murine 5-aminole ...
Mus musculus
PLoS ONE
9
e93078
2014
-
1
1
-
4
-
1
-
1
-
-
1
-
5
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
4
-
-
1
-
-
1
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
1
2
2
1
-
-
736819
Bishop
Molecular expression and chara ...
Homo sapiens
Mol. Med.
19
18-25
2013
-
-
1
-
3
-
-
12
-
-
2
1
-
2
-
-
1
-
-
-
-
-
1
1
1
-
2
-
1
-
-
1
-
-
-
-
-
1
1
-
3
-
-
-
-
12
-
-
2
1
-
-
-
1
-
-
-
-
1
1
1
-
2
-
1
-
-
-
-
1
1
-
-
-
719402
Shaik
Sigma-Aminolevulinate synthase ...
Drosophila melanogaster
Eur. J. Cell Biol.
91
204-215
2012
-
-
-
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
-
1
-
-
-
1
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
1
1
-
-
-
719419
Kadirvel
The carboxyl-terminal region o ...
Homo sapiens
Exp. Hematol.
40
477-486.e1
2012
-
-
1
-
4
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
1
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
718696
Turbeville
Functional asymmetry for the a ...
Mus musculus
Arch. Biochem. Biophys.
511
107-117
2011
-
-
1
-
1
-
-
8
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
1
-
-
4
1
-
-
1
-
-
-
-
-
1
1
-
1
-
-
-
-
8
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
4
1
-
-
-
-
-
-
-
-
-
718890
Zhang
Hypoxic induction of human ery ...
Homo sapiens
Biochemistry
50
1194-1202
2011
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
2
-
-
720074
Kiatpapan
Production of 5-aminolevulinic ...
Acidipropionibacterium acidipropionici
J. Biosci. Bioeng.
111
425-428
2011
-
1
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
1
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
703095
Huang
Erythroid 5-aminolevulinate sy ...
Homo sapiens
Cell Biochem. Funct.
28
122-125
2010
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
703855
Okano
Indispensable function for emb ...
Mus musculus
Genes Cells
15
77-89
2010
-
-
-
-
-
-
-
-
-
-
-
-
-
4
-
-
-
-
-
9
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
9
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
704690
Lendrihas
Serine 254 enhances an induced ...
Mus musculus
J. Biol. Chem.
285
3351-3359
2010
-
-
-
-
2
-
-
6
-
-
-
-
-
6
-
-
-
-
-
1
-
-
1
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
6
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
3
-
-
-
-
-
-
-
-
6
6
719861
Lendrihas
Targeting the active site gate ...
Escherichia coli
J. Biol. Chem.
285
13704-13711
2010
-
-
-
-
9
-
-
16
-
-
-
-
-
3
-
-
-
-
-
-
-
-
1
-
1
-
-
8
1
-
-
1
-
-
-
-
-
-
1
-
9
-
-
-
-
16
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
8
1
-
-
-
-
-
-
-
-
-
691351
Lin
Characterization of 5-aminolev ...
Agrobacterium tumefaciens
Biores. Technol.
100
2293-2297
2009
-
1
1
-
-
-
1
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
701767
Liu
d-Glucose enhanced 5-aminolevu ...
Agrobacterium tumefaciens
Appl. Biochem. Biotechnol.
160
822-830
2009
-
1
1
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
703124
du Plessis
Functional analysis of the 5 r ...
Homo sapiens
Cell. Mol. Biol.
55
20-30
2009
-
-
-
-
1
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
703125
Buzaleh
Induction of hepatic aminolevu ...
Mus musculus
Cell. Mol. Biol.
55
38-44
2009
-
1
-
-
-
-
-
-
-
-
-
-
-
5
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
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5-Aminolevulinic acid synthase ...
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486854
Zavgorodnyaya
Yeast 5-aminolevulinate syntha ...
Saccharomyces cerevisiae
Plant J.
12
169-178
1997
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1
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486851
Gong
Mutations at a glycine loop in ...
Mus musculus, Rattus norvegicus
Biochemistry
35
14109-14117
1996
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1
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4
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10
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5
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5
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486852
Tan
Active site of 5-aminolevulina ...
Mus musculus, Saccharomyces cerevisiae
Biochemistry
35
8934-8941
1996
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1
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5
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4
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2
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8
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4
4
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486849
Ferreira
Aminolevulinate synthase: lysi ...
Mus musculus
Protein Sci.
4
1001-1006
1995
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1
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3
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1
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486850
Ferreira
5-Aminolevulinate synthase and ...
Agrobacterium tumefaciens, Aspergillus nidulans, Bradyrhizobium japonicum, Euglena gracilis, Gallus gallus, Homo sapiens, Mus musculus, Paracoccus denitrificans, Rattus norvegicus, Rhodobacter capsulatus, Rhodobacter sphaeroides, Saccharomyces cerevisiae, Sinorhizobium meliloti
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1995
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6
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17
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8
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14
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13
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6
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14
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486824
Ferreira
Expression of mammalian 5-amin ...
Mus musculus
J. Biol. Chem.
268
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1993
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1
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1
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486847
Lake-Bullock
Biphasic ordered induction of ...
Mus musculus
Mol. Cell. Biol.
13
7122-7132
1993
3
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1
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486848
Munakata
Purification and structure of ...
Rattus norvegicus
J. Biochem.
114
103-111
1993
1
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1
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1
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486808
Bishop
Human delta-aminolevulinate sy ...
Homo sapiens
Genomics
7
207-214
1990
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1
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2
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486814
Ades
Properties of chicken erythroc ...
Gallus gallus
Int. J. Biochem.
20
965-969
1988
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1
2
1
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2
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3
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1
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4
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1
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1
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1
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2
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1
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4
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1
1
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1
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486815
Viale
-
Extraction and characterizatio ...
Rhodopseudomonas palustris
Comp. Biochem. Physiol. B
87
607-613
1987
1
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2
1
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1
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1
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1
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1
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2
2
1
1
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1
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486816
Fernandez
Trout (Salmo gairdenri R.) liv ...
Oncorhynchus mykiss
Comp. Biochem. Physiol. B
86
245-249
1987
-
-
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2
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2
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2
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2
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1
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2
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2
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2
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1
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1
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486818
Borthwick
Purification of hepatic mitoch ...
Gallus gallus, Rattus norvegicus
Methods Enzymol.
123
395-401
1986
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-
-
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-
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6
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2
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2
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2
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4
2
4
4
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2
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6
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4
2
4
4
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2
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486819
Jordan
Purification of 5-aminolevulin ...
Rhodobacter sphaeroides
Methods Enzymol.
123
435-443
1986
-
-
-
-
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5
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2
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1
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1
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1
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1
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1
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1
1
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486839
Sato
-
Purification and some properti ...
Rhodobacter sphaeroides, Serratia plymuthica
Agric. Biol. Chem.
49
3415-3421
1985
2
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4
2
4
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2
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2
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2
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2
1
2
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2
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2
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2
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2
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2
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4
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4
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2
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2
1
2
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2
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2
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-
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486840
Sato
-
Occurence and some properties ...
Serratia plymuthica
Agric. Biol. Chem.
49
3423-3428
1985
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1
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1
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1
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1
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-
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-
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486835
Volland
Isolation and properties of 5- ...
Saccharomyces cerevisiae
Eur. J. Biochem.
142
551-557
1984
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-
-
-
-
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4
2
2
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2
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2
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1
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1
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1
1
1
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1
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1
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4
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2
2
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2
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1
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1
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1
1
1
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1
1
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486823
Scotto
The characterization and submi ...
Rattus norvegicus
J. Biol. Chem.
258
81-90
1983
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-
-
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3
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2
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1
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1
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1
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3
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2
-
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1
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1
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-
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486836
Borthwick
Purification of 5-aminolaevuli ...
Gallus gallus
Eur. J. Biochem.
129
615-620
1983
-
-
-
-
-
-
-
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1
-
1
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1
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1
-
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2
1
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1
1
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1
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1
-
-
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1
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1
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1
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2
1
-
1
1
-
-
-
-
-
-
-
-
-
-
-
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-
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486838
Srivastava
Purification of rat liver mito ...
Rattus norvegicus
Biochem. Biophys. Res. Commun.
109
305-312
1982
-
-
-
-
-
-
-
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1
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2
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1
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1
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1
1
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1
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1
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1
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1
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2
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1
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1
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
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486817
Kreit
Control of 5-aminolevulinic ac ...
Rhodospirillum rubrum
Biochimie
63
439-444
1981
1
-
-
-
-
-
4
-
-
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1
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4
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1
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-
-
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1
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-
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1
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1
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1
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1
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4
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1
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1
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-
-
-
1
-
-
-
-
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1
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-
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486822
Simpson
Purification of a specific act ...
Rattus norvegicus
J. Biol. Chem.
255
1630-1634
1980
2
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-
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2
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4
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2
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-
-
-
2
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1
1
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1
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1
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2
-
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1
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2
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4
-
-
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-
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2
-
-
1
1
-
-
-
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1
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486834
Nakakuki
Purification and some properti ...
Rattus norvegicus
J. Biol. Chem.
255
1738-1745
1980
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3
3
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1
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2
1
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1
1
1
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-
1
-
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1
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-
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-
1
-
-
-
-
-
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3
3
-
2
-
-
-
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1
-
2
1
-
1
1
1
-
-
-
1
-
-
-
-
-
-
-
-
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486825
Davies
Control of 5-aminolaevulinate ...
Rhodobacter sphaeroides
Biochem. J.
177
649-659
1979
-
-
-
-
-
-
-
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3
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1
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1
-
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1
-
1
1
1
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-
-
1
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
3
-
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1
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1
-
1
1
1
-
-
-
1
-
-
-
-
-
-
-
-
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486826
Davies
Control of 5-aminolaevulinate ...
Rhodobacter sphaeroides
Biochem. J.
177
661-671
1979
-
-
-
-
-
-
-
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1
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1
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-
1
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1
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-
-
-
-
-
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-
1
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-
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-
-
1
-
-
-
-
-
-
-
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-
-
-
-
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-
-
-
1
-
1
-
-
-
-
-
-
-
-
-
-
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486833
Paterniti
delta-Aminolevulinic acid synt ...
Rattus norvegicus
J. Biol. Chem.
254
6112-6118
1979
-
-
-
-
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3
1
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2
2
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2
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1
-
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2
1
1
1
1
-
-
-
-
1
-
-
1
-
-
-
-
-
-
1
-
-
-
-
3
-
1
2
2
2
-
-
-
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1
-
2
1
1
1
1
-
-
-
-
1
-
-
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486837
Ohashi
Purification and some properti ...
Rattus norvegicus
J. Biochem.
85
239-247
1979
-
-
-
-
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2
2
2
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2
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2
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1
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2
1
-
1
1
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-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
2
-
2
2
2
2
-
-
-
-
1
-
2
1
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
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486821
Nandi
Studies on delta-aminolevulini ...
Rhodobacter sphaeroides
J. Biol. Chem.
253
8872-8877
1978
-
-
-
-
-
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4
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2
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1
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1
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-
-
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1
2
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-
-
-
1
-
-
-
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4
2
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-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
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486827
Ibrahim
Hemin feedback inhibition at r ...
Oryctolagus cuniculus
Biochem. Biophys. Res. Commun.
80
722-728
1978
-
-
-
-
-
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1
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2
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1
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1
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1
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-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
1
-
-
2
-
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-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
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486832
Whiting
delta-Aminolevulinic acid synt ...
Gallus gallus
J. Biol. Chem.
251
1340-1346
1976
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4
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1
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2
1
2
1
1
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-
-
-
-
-
1
1
-
-
-
-
-
1
-
-
-
-
4
1
-
-
4
2
-
-
-
-
1
-
2
1
2
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
486831
Clement-Metral
5-Aminolevulinic-acid syntheta ...
Rhodobacter sphaeroides, Rhodobacter sphaeroides Y
Eur. J. Biochem.
59
73-77
1975
-
-
-
-
-
-
2
-
-
-
1
-
-
6
-
-
1
-
-
-
1
-
2
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
2
-
-
-
-
1
-
-
-
-
1
-
-
1
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
486830
Hayasaka
Control of delta-aminolevulina ...
Rhodobacter sphaeroides
J. Biochem.
76
157-168
1974
2
-
-
-
-
-
2
-
-
-
-
-
-
2
-
-
1
-
-
-
1
-
1
-
-
-
-
-
-
-
-
1
-
-
-
2
-
-
1
-
-
-
-
2
-
-
-
-
-
-
-
-
-
1
-
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
486841
Murthy
Solubilization and partial pur ...
Rattus norvegicus
Biochim. Biophys. Acta
350
240-246
1974
1
-
-
-
-
-
3
-
2
-
-
-
-
2
-
-
1
-
-
4
1
-
1
-
-
-
-
-
-
-
-
1
-
-
-
1
-
-
1
-
-
-
-
3
-
-
2
-
-
-
-
-
-
1
-
4
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
486809
Ramaswamy
delta-Aminolevulinic acid synt ...
Solanum tuberosum
Biochim. Biophys. Acta
293
269-277
1973
2
-
-
-
-
-
4
-
-
1
-
1
-
1
-
-
-
-
-
1
2
1
2
-
1
-
1
-
1
-
-
1
-
-
-
2
-
-
1
-
-
-
-
4
-
-
-
1
-
1
-
-
-
-
-
1
2
1
2
-
1
-
1
-
1
-
-
-
-
-
-
-
-
-
486810
Tait
Aminolaevulinate synthetase of ...
Paracoccus denitrificans
Biochem. J.
131
389-403
1973
-
-
-
-
-
-
4
3
-
-
1
-
-
1
-
-
1
-
-
1
2
-
1
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
1
-
-
-
-
4
-
3
-
-
1
-
-
-
-
1
-
1
2
-
1
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
486844
Fanica-Gaignier
5-Aminolevulinic-acid syntheta ...
Rhodobacter sphaeroides, Rhodobacter sphaeroides Y
Eur. J. Biochem.
40
13-18
1973
-
-
-
-
-
-
-
-
-
-
2
-
-
6
-
-
1
-
-
-
2
1
2
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
2
-
-
-
-
1
-
-
2
1
2
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
486845
Fanica-Gaignier
5-Aminolevulinic-acid syntheta ...
Rhodobacter sphaeroides, Rhodobacter sphaeroides Y
Eur. J. Biochem.
40
19-24
1973
-
-
-
-
-
-
4
1
-
-
-
-
-
6
-
-
-
1
-
-
-
-
2
-
-
-
-
-
-
-
-
1
3
-
-
-
-
-
1
-
-
-
-
4
3
1
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
486812
Scholnick
Souble delta-aminolevulinic ac ...
Rattus norvegicus
J. Biol. Chem.
247
4126-4131
1972
1
-
-
-
-
1
-
4
1
1
2
1
-
1
-
-
1
-
-
1
1
-
3
-
-
-
-
-
2
-
1
1
-
-
-
1
-
-
1
-
-
1
-
-
-
4
1
1
2
1
-
-
-
1
-
1
1
-
3
-
-
-
-
-
2
-
1
-
-
-
-
-
-
-
486813
Scholnick
Soluble delta-aminolevulinic a ...
Rattus norvegicus
J. Biol. Chem.
247
4132-4137
1972
-
-
-
-
-
-
14
-
1
-
-
-
-
1
-
-
-
1
-
1
-
-
1
-
-
-
-
-
-
-
-
1
1
-
-
-
-
-
1
-
-
-
-
14
1
-
1
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
486820
Jordan
-
delta-Aminolevulinic acid synt ...
Cavia porcellus, Gallus gallus, Homo sapiens, no activity in Chromatium sp., Novispirillum itersonii, Oryctolagus cuniculus, Propionibacterium freudenreichii subsp. shermanii, Rattus norvegicus, Rhodobacter sphaeroides, Rhodospirillum rubrum, Saccharomyces cerevisiae, Spinacia oleracea
The Enzymes, 3rd Ed. (Boyer, P. D. , ed. )
7
339-356
1972
3
-
-
-
-
-
110
9
13
-
5
21
-
12
-
-
3
10
-
10
8
-
62
-
-
-
2
-
-
-
-
11
-
-
-
3
-
-
11
-
-
-
-
110
-
9
13
-
5
21
-
-
-
3
-
10
8
-
62
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
486828
Porra
The nature of the inhibition o ...
Rhodobacter sphaeroides
Arch. Biochem. Biophys.
148
37-43
1972
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-
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-
-
-
1
-
-
-
-
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-
1
-
-
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-
-
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1
-
-
-
-
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1
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-
1
-
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-
-
1
-
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-
-
-
-
-
-
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-
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-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
486842
Yubisui
delta-Aminolevulinic acid synt ...
Rhodobacter sphaeroides
Arch. Biochem. Biophys.
150
77-85
1972
1
-
-
-
-
1
12
-
-
-
1
-
-
1
-
-
1
-
-
-
1
1
1
-
-
-
-
-
1
-
-
1
-
-
-
1
-
-
1
-
-
1
-
12
-
-
-
-
1
-
-
-
-
1
-
-
1
1
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
486843
Whiting
Purification and properties of ...
Cavia porcellus, Rattus norvegicus
J. Biol. Chem.
247
6818-6826
1972
-
-
-
-
-
-
2
3
5
-
2
-
-
2
-
-
2
-
-
2
-
2
2
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
2
-
-
-
-
2
-
3
5
-
2
-
-
-
-
2
-
2
-
2
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
486811
Warnick
Regulation of prophyrin biosyn ...
Rhodobacter sphaeroides
J. Biol. Chem.
246
6880-6885
1971
1
-
-
-
-
1
3
-
-
1
1
-
-
1
-
-
1
-
-
-
1
2
2
2
-
-
1
-
1
-
-
1
-
-
-
1
-
-
1
-
-
1
-
3
-
-
-
1
1
-
-
-
-
1
-
-
1
2
2
2
-
-
1
-
1
-
-
-
-
-
-
-
-
-
486829
Tuboi
Control of delta-aminolevulina ...
Rhodobacter sphaeroides
Arch. Biochem. Biophys.
146
282-290
1971
-
-
-
-
-
-
-
-
-
-
2
-
-
1
-
-
1
-
-
-
1
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
2
-
-
-
-
1
-
-
1
-
1
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-