Literature summary for 2.3.1.36 extracted from

Yow, G.Y.; Uo, T.; Yoshimura, T.; Esaki, N.
Physiological role of D-amino acid-N-acetyltransferase of Saccharomyces cerevisiae: detoxification of D-amino acids (2006), Arch. Microbiol., 185, 39-46.

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Cloned(Commentary)

Cloned (Comment)	Organism
when the gene is overexpressed with a vector plasmid p426Gal1 in the wild type Saccharomyces cerevisiae as a host, the recombinant yeast, which shows more than 100 times higher D-amino acid-N-acetyltransferase activity than the wild type, is much more tolerant to D-amino acids than the wild type	Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
acetyl-CoA + a D-amino acid	Saccharomyces cerevisiae	D-amino acids are toxic to Saccharomyces cerevisiae but are detoxified with D-amino acid-N-acetyltransferase by N-acetylation preceding removal from yeast cells	CoA + an N-acetyl-D-amino acid	-	?

Organism

Organism	UniProt	Comment	Textmining
Saccharomyces cerevisiae	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
acetyl-CoA + a D-amino acid	D-amino acids are toxic to Saccharomyces cerevisiae but are detoxified with D-amino acid-N-acetyltransferase by N-acetylation preceding removal from yeast cells	Saccharomyces cerevisiae	CoA + an N-acetyl-D-amino acid	-	?

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Release 2023.1 (January 2023)