Cloned (Comment) | Organism |
---|---|
bovine partial | Mus musculus |
bovine partial | Homo sapiens |
bovine partial | Bos taurus |
bovine partial | Escherichia coli |
expressed in Escherichia coli | Mus musculus |
expressed in Escherichia coli | Homo sapiens |
expressed in Escherichia coli | Bos taurus |
expressed in Escherichia coli | Escherichia coli |
Crystallization (Comment) | Organism |
---|---|
external aldimine in the crystal structure, interaction between aldimine and the side chains in the substrate binding site explain the specificity to the substrate | Escherichia coli |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | enzyme synthesized in cytoplasm | Homo sapiens | 5737 | - |
mitochondrion | - |
Mus musculus | 5739 | - |
mitochondrion | - |
Bos taurus | 5739 | - |
mitochondrion | enzyme imported into mitochondrion from cytoplasm | Homo sapiens | 5739 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
43000 | - |
2 * 43000, SDS-PAGE | Escherichia coli |
80000 | - |
dynamic ligth scattering measurement | Escherichia coli |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + glycine | Mus musculus | enzyme catalyzes the second reaction step on the main metabolic degradation pathway for threonine | CoA + 2-amino-3-oxobutanoate | - |
? | |
acetyl-CoA + glycine | Homo sapiens | enzyme catalyzes the second reaction step on the main metabolic degradation pathway for threonine | CoA + 2-amino-3-oxobutanoate | - |
? | |
acetyl-CoA + glycine | Bos taurus | enzyme catalyzes the second reaction step on the main metabolic degradation pathway for threonine | CoA + 2-amino-3-oxobutanoate | - |
? | |
acetyl-CoA + glycine | Escherichia coli | enzyme catalyzes the second reaction step on the main metabolic degradation pathway for threonine | CoA + 2-amino-3-oxobutanoate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | - |
- |
- |
Escherichia coli | P0AB77 | - |
- |
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Bos taurus |
- |
Escherichia coli |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
acetyl-CoA + glycine = CoA + L-2-amino-3-oxobutanoate | reaction mechanism | Escherichia coli |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Homo sapiens | - |
heart | - |
Homo sapiens | - |
liver | - |
Bos taurus | - |
lung | - |
Mus musculus | - |
lung | - |
Homo sapiens | - |
pancreas | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + glycine | - |
Mus musculus | CoA + 2-amino-3-oxobutanoate | spontaneous decarboxylation to aminoacetone | r | |
acetyl-CoA + glycine | - |
Homo sapiens | CoA + 2-amino-3-oxobutanoate | spontaneous decarboxylation to aminoacetone | r | |
acetyl-CoA + glycine | - |
Bos taurus | CoA + 2-amino-3-oxobutanoate | spontaneous decarboxylation to aminoacetone | r | |
acetyl-CoA + glycine | - |
Escherichia coli | CoA + 2-amino-3-oxobutanoate | spontaneous decarboxylation to aminoacetone | ? | |
acetyl-CoA + glycine | enzyme catalyzes the second reaction step on the main metabolic degradation pathway for threonine | Mus musculus | CoA + 2-amino-3-oxobutanoate | - |
? | |
acetyl-CoA + glycine | enzyme catalyzes the second reaction step on the main metabolic degradation pathway for threonine | Homo sapiens | CoA + 2-amino-3-oxobutanoate | - |
? | |
acetyl-CoA + glycine | enzyme catalyzes the second reaction step on the main metabolic degradation pathway for threonine | Bos taurus | CoA + 2-amino-3-oxobutanoate | - |
? | |
acetyl-CoA + glycine | enzyme catalyzes the second reaction step on the main metabolic degradation pathway for threonine | Escherichia coli | CoA + 2-amino-3-oxobutanoate | - |
? |
Subunits | Comment | Organism |
---|---|---|
dimer | - |
Bos taurus |
dimer | 2 * 43000, SDS-PAGE | Escherichia coli |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
pyridoxal 5'-phosphate | - |
Bos taurus | |
pyridoxal 5'-phosphate | - |
Escherichia coli |