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Literature summary for 2.3.1.29 extracted from

  • Fubara, B.; Eckenrode, F.; Tressel, T.; Davis, L.
    Purification and properties of aminoacetone synthetase from beef liver mitochondria (1986), J. Biol. Chem., 261, 12189-12196.
    View publication on PubMed

General Stability

General Stability Organism
glycerol, 10% v/v, stabilizes Bos taurus
glycine stabilizes Bos taurus

Inhibitors

Inhibitors Comment Organism Structure
Glycine methyl ester inactivation Bos taurus
IAA
-
Bos taurus
additional information no inhibition by DTNB Bos taurus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.053
-
acetyl-CoA
-
Bos taurus
22
-
glycine
-
Bos taurus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
Bos taurus 5739
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
28000
-
2 * 28000, SDS-PAGE, 2 * 29165, calculated from amino acid composition Bos taurus
29165
-
2 * 28000, SDS-PAGE, 2 * 29165, calculated from amino acid composition Bos taurus
56000
-
gel filtration Bos taurus
58330
-
calculated from amino acid composition Bos taurus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acetyl-CoA + glycine Bos taurus involved in L-threonine catabolism, inducible CoA + 2-amino-3-oxobutanoate
-
?

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Bos taurus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Bos taurus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
16.4
-
-
Bos taurus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-CoA + aminomalonate
-
Bos taurus CoA + CO2 + 2-amino-3-oxobutanoate same product as in reaction with glycine, aminomalonate is decarboxylated to glycine by the enzyme, in the absence of acetyl-CoA: glycine is the product ?
acetyl-CoA + glycine specific for glycine Bos taurus CoA + 2-amino-3-oxobutanoate spontaneous decarboxylation to aminoacetone r
acetyl-CoA + glycine succinyl-CoA Bos taurus CoA + 2-amino-3-oxobutanoate spontaneous decarboxylation to aminoacetone r
acetyl-CoA + glycine not: acetyl phosphate Bos taurus CoA + 2-amino-3-oxobutanoate spontaneous decarboxylation to aminoacetone r
acetyl-CoA + glycine no substrate: L-alanine Bos taurus CoA + 2-amino-3-oxobutanoate spontaneous decarboxylation to aminoacetone r
acetyl-CoA + glycine no substrate: glycine methylester Bos taurus CoA + 2-amino-3-oxobutanoate spontaneous decarboxylation to aminoacetone r
acetyl-CoA + glycine acetyl-CoA cannot be replaced by acetyl phosphate Bos taurus CoA + 2-amino-3-oxobutanoate spontaneous decarboxylation to aminoacetone r
acetyl-CoA + glycine involved in L-threonine catabolism, inducible Bos taurus CoA + 2-amino-3-oxobutanoate
-
?

Subunits

Subunits Comment Organism
dimer 2 * 28000, SDS-PAGE, 2 * 29165, calculated from amino acid composition Bos taurus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
assay at Bos taurus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
additional information
-
pI: 5.2 Bos taurus
7.5
-
-
Bos taurus

pH Stability

pH Stability pH Stability Maximum Comment Organism
6.5 8 stable Bos taurus

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate requirement, stoichiometry: 1 mol per mol subunit Bos taurus