Literature summary for 2.3.1.289 extracted from

Busch, B.; Hertweck, C.
Evolution of metabolic diversity in polyketide-derived pyrones Using the non-colinear aureothin assembly line as a model system (2009), Phytochemistry, 70, 1833-1840 .

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Cloned(Commentary)

Cloned (Comment)	Organism
expression of subunit AurA in Streptomyces lividans	Streptomyces thioluteus

Protein Variants

Protein Variants	Comment	Organism
additional information	construction of mutant protein complexes each lacking a critical PKS domain on subunit AurA domain for chain propagation	Streptomyces thioluteus

Organism

Organism	UniProt	Comment	Textmining
Streptomyces thioluteus	Q70KH8 and Q70KH5 and Q70KH4	Q70KH8 i.e. subunit AurA, Q70KH5 i.e. subunit AurB, Q70KH4 i.e. subunit AurC	-
Streptomyces thioluteus HKI-227	Q70KH8 and Q70KH5 and Q70KH4	Q70KH8 i.e. subunit AurA, Q70KH5 i.e. subunit AurB, Q70KH4 i.e. subunit AurC	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
4-nitrobenzoyl-CoA + malonyl-CoA + 4 (S)-methylmalonyl-CoA + 4 NADPH + 4 H+	-	Streptomyces thioluteus	demethylluteothin + 5 CO2 + 6 CoA + 4 NADP+ + 3 H2O	-	?
4-nitrobenzoyl-CoA + malonyl-CoA + 4 (S)-methylmalonyl-CoA + 4 NADPH + 4 H+	-	Streptomyces thioluteus HKI-227	demethylluteothin + 5 CO2 + 6 CoA + 4 NADP+ + 3 H2O	-	?

General Information

General Information	Comment	Organism
physiological function	model of the itinerative action of polyketide synthase. The ACP-bound polyketide intermediate is transferred back to the ketosynthase domain on the opposite polyketide synthase strand. the AurA N-terminus is not involved in the iteration process	Streptomyces thioluteus

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Release 2023.1 (January 2023)