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Literature summary for 2.3.1.289 extracted from

  • He, J.; Hertweck, C.
    Functional analysis of the aureothin iterative type I polyketide syntase (2005), ChemBioChem, 6, 908-912 .
    View publication on PubMed
Search for more literature for 2.3.1.289

Organism

Organism UniProt Comment Textmining
Streptomyces thioluteus Q70KH8 and Q70KH5 and Q70KH4 Q70KH8 i.e. subunit AurA, Q70KH5 i.e. subunit AurB, Q70KH4 i.e. subunit AurC
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Streptomyces thioluteus HKI-227 Q70KH8 and Q70KH5 and Q70KH4 Q70KH8 i.e. subunit AurA, Q70KH5 i.e. subunit AurB, Q70KH4 i.e. subunit AurC
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-nitrobenzoyl-CoA + malonyl-CoA + 4 (S)-methylmalonyl-CoA + 4 NADPH + 4 H+
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 Streptomyces thioluteus demethylluteothin + 5 CO2 + 6 CoA + 4 NADP+ + 3 H2O
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 ?
4-nitrobenzoyl-CoA + malonyl-CoA + 4 (S)-methylmalonyl-CoA + 4 NADPH + 4 H+
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 Streptomyces thioluteus HKI-227 demethylluteothin + 5 CO2 + 6 CoA + 4 NADP+ + 3 H2O
-
 ?

General Information

General Information Comment Organism
physiological function heterologous expression of an engineered AurAB fusion protein. Inactivation the ketosynthase or acyl carrier domains of module 4 clearly result in a shutdown of polyketide biosynthesis. Module 4 is required for the biosynthesis of polyketide production, and, despite the apparently inactive AT4 domain, an iterative use of the entirety of module 3 seems not to take place Streptomyces thioluteus