Literature summary for 2.3.1.286 extracted from

Starai, V.J.; Celic, I.; Cole, R.N.; Boeke, J.D.; Escalante-Semerena, J.C.
Sir2-dependent activation of acetyl-CoA synthetase by deacetylation of active lysine (2002), Science, 298, 2390-2392 .

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Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
[Acs protein]-N6-acetyl-L-lysine609 + NAD+ + H2O	Salmonella enterica	the enzyme activates Acs protein by deacetylation	[Acs protein]-L-lysine609 + 2''-O-acetyl-ADP-D-ribose + nicotinamide	-	?

Organism

Organism	UniProt	Comment	Textmining
Salmonella enterica	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
[Acs protein]-N6-acetyl-L-lysine609 + NAD+ + H2O	the enzyme activates Acs protein by deacetylation	Salmonella enterica	[Acs protein]-L-lysine609 + 2''-O-acetyl-ADP-D-ribose + nicotinamide	-	?

Synonyms

Synonyms	Comment	Organism
CobB	-	Salmonella enterica
nicotinamide adenine dinucleotide-dependent protein deacetylase	-	Salmonella enterica
Sir2	-	Salmonella enterica

Cofactor

Cofactor	Comment	Organism	Structure
NAD+	-	Salmonella enterica

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Release 2023.1 (January 2023)