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Literature summary for 2.3.1.286 extracted from

  • Dancy, B.C.; Ming, S.A.; Papazyan, R.; Jelinek, C.A.; Majumdar, A.; Sun, Y.; Dancy, B.M.; Drury, W.J.; Cotter, R.J.; Taverna, S.D.; Cole, P.A.
    Azalysine analogues as probes for protein lysine deacetylation and demethylation (2012), J. Am. Chem. Soc., 134, 5138-5148 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
-
Thermotoga maritima

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0109
-
K382azaKAc-containing p53 peptide at 37°C, pH not specified in the publication Thermotoga maritima
0.0718
-
K382KAc-containing p53 peptide at 37°C, pH not specified in the publication Thermotoga maritima

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
[protein]-N6-acetyl-L-lysine + NAD+ Thermotoga maritima
-
[protein]-N6-[1,1-(5-adenosylyl-alpha-D-ribose-1,2-di-O-yl)ethyl]-L-lysine + nicotinamide
-
?
[protein]-N6-acetyl-L-lysine + NAD+ + H2O Thermotoga maritima overall reaction [protein]-L-lysine + 2''-O-acetyl-ADP-D-ribose + nicotinamide
-
?
[protein]-N6-[1,1-(5-adenosylyl-alpha-D-ribose-1,2-di-O-yl)ethyl]-L-lysine + H2O Thermotoga maritima
-
[protein]-L-lysine + 2''-O-acetyl-ADP-D-ribose
-
?

Organism

Organism UniProt Comment Textmining
Thermotoga maritima
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Thermotoga maritima

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
K382azaKAc-containing p53 peptide + NAD+ + H2O
-
Thermotoga maritima K382azaK-containing p53 peptide + 2''-O-acetyl-ADP-D-ribose + nicotinamide
-
?
K382KAc-containing p53 peptide + NAD+ + H2O
-
Thermotoga maritima K382K-containing p53 peptide + 2''-O-acetyl-ADP-D-ribose + nicotinamide
-
?
[protein]-N6-acetyl-L-lysine + NAD+
-
Thermotoga maritima [protein]-N6-[1,1-(5-adenosylyl-alpha-D-ribose-1,2-di-O-yl)ethyl]-L-lysine + nicotinamide
-
?
[protein]-N6-acetyl-L-lysine + NAD+ + H2O overall reaction Thermotoga maritima [protein]-L-lysine + 2''-O-acetyl-ADP-D-ribose + nicotinamide
-
?
[protein]-N6-[1,1-(5-adenosylyl-alpha-D-ribose-1,2-di-O-yl)ethyl]-L-lysine + H2O
-
Thermotoga maritima [protein]-L-lysine + 2''-O-acetyl-ADP-D-ribose
-
?

Synonyms

Synonyms Comment Organism
Sir2
-
Thermotoga maritima

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.023
-
K382azaKAc-containing p53 peptide at 37°C, pH not specified in the publication Thermotoga maritima
0.18
-
K382KAc-containing p53 peptide at 37°C, pH not specified in the publication Thermotoga maritima

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Thermotoga maritima