Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | - |
Homo sapiens | 5737 | - |
cytoplasm | - |
Saccharomyces cerevisiae | 5737 | - |
nucleus | - |
Homo sapiens | 5634 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Zn2+ | contains zinc | Archaeoglobus fulgidus | |
Zn2+ | contains zinc | Homo sapiens | |
Zn2+ | contains zinc | Saccharomyces cerevisiae |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
[protein]-N6-acetyl-L-lysine + NAD+ + H2O | Archaeoglobus fulgidus | overall reaction | [protein]-L-lysine + 2''-O-acetyl-ADP-D-ribose + nicotinamide | - |
? | |
[protein]-N6-acetyl-L-lysine + NAD+ + H2O | Homo sapiens | overall reaction | [protein]-L-lysine + 2''-O-acetyl-ADP-D-ribose + nicotinamide | - |
? | |
[protein]-N6-acetyl-L-lysine + NAD+ + H2O | Saccharomyces cerevisiae | overall reaction | [protein]-L-lysine + 2''-O-acetyl-ADP-D-ribose + nicotinamide | - |
? | |
[protein]-N6-acetyl-L-lysine + NAD+ + H2O | Archaeoglobus fulgidus ATCC 49558 | overall reaction | [protein]-L-lysine + 2''-O-acetyl-ADP-D-ribose + nicotinamide | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Archaeoglobus fulgidus | O28597 | - |
- |
Archaeoglobus fulgidus ATCC 49558 | O28597 | - |
- |
Homo sapiens | Q8IXJ6 | - |
- |
Saccharomyces cerevisiae | P53686 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
[alpha-tubulin]-N6-acetyl-L-lysine40 + NAD+ + H2O | - |
Homo sapiens | [alpha-tubulin]-L-lysine40 + 2''-O-acetyl-ADP-D-ribose + nicotinamide | - |
? | |
[protein]-N6-acetyl-L-lysine + NAD+ + H2O | overall reaction | Archaeoglobus fulgidus | [protein]-L-lysine + 2''-O-acetyl-ADP-D-ribose + nicotinamide | - |
? | |
[protein]-N6-acetyl-L-lysine + NAD+ + H2O | overall reaction | Homo sapiens | [protein]-L-lysine + 2''-O-acetyl-ADP-D-ribose + nicotinamide | - |
? | |
[protein]-N6-acetyl-L-lysine + NAD+ + H2O | overall reaction | Saccharomyces cerevisiae | [protein]-L-lysine + 2''-O-acetyl-ADP-D-ribose + nicotinamide | - |
? | |
[protein]-N6-acetyl-L-lysine + NAD+ + H2O | overall reaction | Archaeoglobus fulgidus ATCC 49558 | [protein]-L-lysine + 2''-O-acetyl-ADP-D-ribose + nicotinamide | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Hst2p | - |
Saccharomyces cerevisiae |
Sir2 | - |
Archaeoglobus fulgidus |
Sir2 | - |
Homo sapiens |
Sir2 | - |
Saccharomyces cerevisiae |
SIR2-Af1 | - |
Archaeoglobus fulgidus |
Sir2-Af2 | - |
Archaeoglobus fulgidus |
SIRT2 | - |
Homo sapiens |
sirtuin | - |
Archaeoglobus fulgidus |
sirtuin | - |
Homo sapiens |
sirtuin | - |
Saccharomyces cerevisiae |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | - |
Archaeoglobus fulgidus | |
NAD+ | - |
Homo sapiens | |
NAD+ | - |
Saccharomyces cerevisiae |
General Information | Comment | Organism |
---|---|---|
physiological function | Sirt2 may act as a tumor suppressor and may function to control the cell cycle by acetylation of alpha-tubulin | Homo sapiens |