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Literature summary for 2.3.1.286 extracted from

  • Smith, B.C.; Denu, J.M.
    Sir2 protein deacetylases evidence for chemical intermediates and functions of a conserved histidine (2006), Biochemistry, 45, 272-282 .
    View publication on PubMedView publication on EuropePMC

Protein Variants

Protein Variants Comment Organism
H135A the kcat/Km profile for the mutant exhibits no pH dependence over the range tested (pH 5.4-9.4), with kcat/Km values 2 orders of magnitude lower than wild type at high pH values Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
[protein]-N6-acetyl-L-lysine + NAD+ Saccharomyces cerevisiae
-
[protein]-N6-[1,1-(5-adenosylyl-alpha-D-ribose-1,2-di-O-yl)ethyl]-L-lysine + nicotinamide
-
?
[protein]-N6-acetyl-L-lysine + NAD+ + H2O Saccharomyces cerevisiae overall reaction [protein]-L-lysine + 2''-O-acetyl-ADP-D-ribose + nicotinamide
-
?
[protein]-N6-[1,1-(5-adenosylyl-alpha-D-ribose-1,2-di-O-yl)ethyl]-L-lysine + H2O Saccharomyces cerevisiae
-
[protein]-L-lysine + 2''-O-acetyl-ADP-D-ribose
-
?

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
KSTGGAcKAPRKQ + NAD+ + H2O
-
Saccharomyces cerevisiae KSTGGKAPRKQ + 2''-O-acetyl-ADP-D-ribose + nicotinamide
-
?
[histone H3]-N6-acetyl-L-lysine + NAD+ + H2O
-
Saccharomyces cerevisiae [histone H3]-L-lysine + 2''-O-acetyl-ADP-D-ribose + nicotinamide
-
?
[protein]-N6-acetyl-L-lysine + NAD+
-
Saccharomyces cerevisiae [protein]-N6-[1,1-(5-adenosylyl-alpha-D-ribose-1,2-di-O-yl)ethyl]-L-lysine + nicotinamide
-
?
[protein]-N6-acetyl-L-lysine + NAD+ + H2O overall reaction Saccharomyces cerevisiae [protein]-L-lysine + 2''-O-acetyl-ADP-D-ribose + nicotinamide
-
?
[protein]-N6-[1,1-(5-adenosylyl-alpha-D-ribose-1,2-di-O-yl)ethyl]-L-lysine + H2O
-
Saccharomyces cerevisiae [protein]-L-lysine + 2''-O-acetyl-ADP-D-ribose
-
?

Synonyms

Synonyms Comment Organism
HST2
-
Saccharomyces cerevisiae
Sir2
-
Saccharomyces cerevisiae

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Saccharomyces cerevisiae

kcat/KM [mM/s]

kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
0.15
-
KSTGGAcKAPRKQ mutant enzyme H135A, at pH 7.5 and 25°C Saccharomyces cerevisiae
2.2
-
KSTGGAcKAPRKQ wild type enzyme, at pH 7.5 and 25°C Saccharomyces cerevisiae