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Literature summary for 2.3.1.286 extracted from

  • Sauve, A.A.; Schramm, V.L.
    Sir2 regulation by nicotinamide results from switching between base exchange and deacetylation chemistry (2003), Biochemistry, 42, 9249-9256 .
    View publication on PubMed
Search for more literature for 2.3.1.286

Inhibitors

Inhibitors Comment Organism Structure
Benzamide 5% inhibition at 5 mM Archaeoglobus fulgidus
Benzamide 44% inhibition at 5 mM Mus musculus
Isonicotinamide 4% inhibition at 5 mM Archaeoglobus fulgidus
Isonicotinamide 18% inhibition at 5 mM Mus musculus
Isonicotinamide 5% inhibition at 42 mM Saccharomyces cerevisiae
additional information not inhibited by benzamide Saccharomyces cerevisiae
nicotinamide
-
 Archaeoglobus fulgidus
nicotinamide
-
 Mus musculus
nicotinamide
-
 Saccharomyces cerevisiae
Pyrazinamide 4% inhibition at 5 mM Archaeoglobus fulgidus
Pyrazinamide 1% inhibition at 5 mM Mus musculus
Pyrazinamide 1% inhibition at 5 mM Saccharomyces cerevisiae
Thionicotinamide 4% inhibition at 5 mM Archaeoglobus fulgidus
Thionicotinamide 16% inhibition at 5 mM Mus musculus
Thionicotinamide 15% inhibition at 5 mM Saccharomyces cerevisiae

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.037
-
 nicotinamide at pH 5.0 and 37°C Mus musculus
0.037
-
 nicotinamide at pH 5.0 and 37°C Saccharomyces cerevisiae
0.037
-
 nicotinamide at pH 5.0 and 37°C Archaeoglobus fulgidus
0.127
-
 nicotinamide at pH 5.0 and 37°C Mus musculus
0.127
-
 nicotinamide at pH 5.0 and 37°C Saccharomyces cerevisiae
0.127
-
 nicotinamide at pH 5.0 and 37°C Archaeoglobus fulgidus
0.16
-
 nicotinamide at pH 5.0 and 37°C Mus musculus
0.16
-
 nicotinamide at pH 5.0 and 37°C Saccharomyces cerevisiae
0.16
-
 nicotinamide at pH 5.0 and 37°C Archaeoglobus fulgidus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
[protein]-L-lysine + 2''-O-acetyl-ADP-D-ribose + nicotinamide Mus musculus
-
 [protein]-N6-acetyl-L-lysine + NAD+ + H2O
-
 r
[protein]-L-lysine + 2''-O-acetyl-ADP-D-ribose + nicotinamide Saccharomyces cerevisiae
-
 [protein]-N6-acetyl-L-lysine + NAD+ + H2O
-
 r
[protein]-L-lysine + 2''-O-acetyl-ADP-D-ribose + nicotinamide Archaeoglobus fulgidus
-
 [protein]-N6-acetyl-L-lysine + NAD+ + H2O
-
 r
[protein]-N6-acetyl-L-lysine + NAD+ Mus musculus
-
 [protein]-N6-[1,1-(5-adenosylyl-alpha-D-ribose-1,2-di-O-yl)ethyl]-L-lysine + nicotinamide
-
 ?
[protein]-N6-acetyl-L-lysine + NAD+ Saccharomyces cerevisiae
-
 [protein]-N6-[1,1-(5-adenosylyl-alpha-D-ribose-1,2-di-O-yl)ethyl]-L-lysine + nicotinamide
-
 ?
[protein]-N6-acetyl-L-lysine + NAD+ Archaeoglobus fulgidus
-
 [protein]-N6-[1,1-(5-adenosylyl-alpha-D-ribose-1,2-di-O-yl)ethyl]-L-lysine + nicotinamide
-
 ?
[protein]-N6-acetyl-L-lysine + NAD+ + H2O Mus musculus overall reaction [protein]-L-lysine + 2''-O-acetyl-ADP-D-ribose + nicotinamide
-
 r
[protein]-N6-acetyl-L-lysine + NAD+ + H2O Saccharomyces cerevisiae overall reaction [protein]-L-lysine + 2''-O-acetyl-ADP-D-ribose + nicotinamide
-
 r
[protein]-N6-acetyl-L-lysine + NAD+ + H2O Archaeoglobus fulgidus overall reaction [protein]-L-lysine + 2''-O-acetyl-ADP-D-ribose + nicotinamide
-
 r
[protein]-N6-[1,1-(5-adenosylyl-alpha-D-ribose-1,2-di-O-yl)ethyl]-L-lysine + H2O Mus musculus
-
 [protein]-L-lysine + 2''-O-acetyl-ADP-D-ribose
-
 ?
[protein]-N6-[1,1-(5-adenosylyl-alpha-D-ribose-1,2-di-O-yl)ethyl]-L-lysine + H2O Saccharomyces cerevisiae
-
 [protein]-L-lysine + 2''-O-acetyl-ADP-D-ribose
-
 ?
[protein]-N6-[1,1-(5-adenosylyl-alpha-D-ribose-1,2-di-O-yl)ethyl]-L-lysine + H2O Archaeoglobus fulgidus
-
 [protein]-L-lysine + 2''-O-acetyl-ADP-D-ribose
-
 ?

Organism

Organism UniProt Comment Textmining
Archaeoglobus fulgidus
-
-
-
Mus musculus
-
-
-
Saccharomyces cerevisiae
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
KKGQSTSRHKKAcLMFKTEG + NAD+ + H2O
-
 Mus musculus KKGQSTSRHKKLMFKTEG + 2''-O-acetyl-ADP-D-ribose + nicotinamide
-
 r
KKGQSTSRHKKAcLMFKTEG + NAD+ + H2O
-
 Saccharomyces cerevisiae KKGQSTSRHKKLMFKTEG + 2''-O-acetyl-ADP-D-ribose + nicotinamide
-
 r
KKGQSTSRHKKAcLMFKTEG + NAD+ + H2O
-
 Archaeoglobus fulgidus KKGQSTSRHKKLMFKTEG + 2''-O-acetyl-ADP-D-ribose + nicotinamide
-
 r
KKGQSTSRHKLMFKTEG + 2''-O-acetyl-ADP-D-ribose + nicotinamide
-
 Mus musculus KKGQSTSRHKKAcLMFKTEG + NAD+ + H2O
-
 r
KKGQSTSRHKLMFKTEG + 2''-O-acetyl-ADP-D-ribose + nicotinamide
-
 Saccharomyces cerevisiae KKGQSTSRHKKAcLMFKTEG + NAD+ + H2O
-
 r
KKGQSTSRHKLMFKTEG + 2''-O-acetyl-ADP-D-ribose + nicotinamide
-
 Archaeoglobus fulgidus KKGQSTSRHKKAcLMFKTEG + NAD+ + H2O
-
 r
[protein]-L-lysine + 2''-O-acetyl-ADP-D-ribose + nicotinamide
-
 Mus musculus [protein]-N6-acetyl-L-lysine + NAD+ + H2O
-
 r
[protein]-L-lysine + 2''-O-acetyl-ADP-D-ribose + nicotinamide
-
 Saccharomyces cerevisiae [protein]-N6-acetyl-L-lysine + NAD+ + H2O
-
 r
[protein]-L-lysine + 2''-O-acetyl-ADP-D-ribose + nicotinamide
-
 Archaeoglobus fulgidus [protein]-N6-acetyl-L-lysine + NAD+ + H2O
-
 r
[protein]-N6-acetyl-L-lysine + NAD+
-
 Mus musculus [protein]-N6-[1,1-(5-adenosylyl-alpha-D-ribose-1,2-di-O-yl)ethyl]-L-lysine + nicotinamide
-
 ?
[protein]-N6-acetyl-L-lysine + NAD+
-
 Saccharomyces cerevisiae [protein]-N6-[1,1-(5-adenosylyl-alpha-D-ribose-1,2-di-O-yl)ethyl]-L-lysine + nicotinamide
-
 ?
[protein]-N6-acetyl-L-lysine + NAD+
-
 Archaeoglobus fulgidus [protein]-N6-[1,1-(5-adenosylyl-alpha-D-ribose-1,2-di-O-yl)ethyl]-L-lysine + nicotinamide
-
 ?
[protein]-N6-acetyl-L-lysine + NAD+ + H2O overall reaction Mus musculus [protein]-L-lysine + 2''-O-acetyl-ADP-D-ribose + nicotinamide
-
 r
[protein]-N6-acetyl-L-lysine + NAD+ + H2O overall reaction Saccharomyces cerevisiae [protein]-L-lysine + 2''-O-acetyl-ADP-D-ribose + nicotinamide
-
 r
[protein]-N6-acetyl-L-lysine + NAD+ + H2O overall reaction Archaeoglobus fulgidus [protein]-L-lysine + 2''-O-acetyl-ADP-D-ribose + nicotinamide
-
 r
[protein]-N6-[1,1-(5-adenosylyl-alpha-D-ribose-1,2-di-O-yl)ethyl]-L-lysine + H2O
-
 Mus musculus [protein]-L-lysine + 2''-O-acetyl-ADP-D-ribose
-
 ?
[protein]-N6-[1,1-(5-adenosylyl-alpha-D-ribose-1,2-di-O-yl)ethyl]-L-lysine + H2O
-
 Saccharomyces cerevisiae [protein]-L-lysine + 2''-O-acetyl-ADP-D-ribose
-
 ?
[protein]-N6-[1,1-(5-adenosylyl-alpha-D-ribose-1,2-di-O-yl)ethyl]-L-lysine + H2O
-
 Archaeoglobus fulgidus [protein]-L-lysine + 2''-O-acetyl-ADP-D-ribose
-
 ?

Synonyms

Synonyms Comment Organism
Sir2Af2
-
 Archaeoglobus fulgidus
Sir2alpha
-
 Mus musculus
Sir2p
-
 Saccharomyces cerevisiae

Cofactor

Cofactor Comment Organism Structure
NAD+
-
 Mus musculus
NAD+
-
 Saccharomyces cerevisiae
NAD+
-
 Archaeoglobus fulgidus