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Literature summary for 2.3.1.286 extracted from

  • Aragones, G.; Suarez, M.; Ardid-Ruiz, A.; Vinaixa, M.; Rodriguez, M.A.; Correig, X.; Arola, L.; Blade, C.
    Dietary proanthocyanidins boost hepatic NAD+ metabolism and SIRT1 expression and activity in a dose-dependent manner in healthy rats (2016), Sci. Rep., 6, 24977.
    View publication on PubMedView publication on EuropePMC
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
NAD+ + [protein]-N6-acyl-L-lysine Rattus norvegicus
-
 nicotinamide + [protein]-L-lysine + 2'-O-acyl-ADP-ribose
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
NAD+ + L-Arg-L-His-L-Lys-L-Lys(epsilon-acetyl)-7-amido-4-methylcoumarin
-
 Rattus norvegicus nicotinamide + ?
-
 ?
NAD+ + [protein]-N6-acyl-L-lysine
-
 Rattus norvegicus nicotinamide + [protein]-L-lysine + 2'-O-acyl-ADP-ribose
-
 ?

Synonyms

Synonyms Comment Organism
SIRT1
-
 Rattus norvegicus
sirtuin 1
-
 Rattus norvegicus

Expression

Organism Comment Expression
Rattus norvegicus grape seed proanthocyanidin consumption robustly enhances both the hepatic Sirt1 mRNA levels and SIRT1 activity in a dose-dependent manner up

General Information

General Information Comment Organism
physiological function the activation of SIRT1 is significantly associated with improved protection against hepatic triglyceride accumulation Rattus norvegicus