Inhibitors | Comment | Organism | Structure |
---|---|---|---|
cambinol | - |
Homo sapiens | |
cambinol | - |
Rattus norvegicus | |
Ex257 | specific inhibitor of isoform SIRT1 | Homo sapiens | |
Ex257 | specific inhibitor of isoform SIRT1 | Rattus norvegicus | |
N-methyl-N-nitrosourea | - |
Homo sapiens | |
N-methyl-N-nitrosourea | - |
Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
NAD+ + [BMAL1 protein]-N6-acyl-L-lysine | Rattus norvegicus | - |
nicotinamide + [BMAL1 protein]-L-lysine + 2'-O-acyl-ADP-ribose | - |
? | |
NAD+ + [BMAL1 protein]-N6-acyl-L-lysine | Homo sapiens | - |
nicotinamide + [BMAL1 protein]-L-lysine + 2'-O-acyl-ADP-ribose | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q96EB6 | - |
- |
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
mammary epithelial cell | - |
Rattus norvegicus | - |
mammary epithelial cell | - |
Homo sapiens | - |
MCF-10A cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
NAD+ + [BMAL1 protein]-N6-acyl-L-lysine | - |
Rattus norvegicus | nicotinamide + [BMAL1 protein]-L-lysine + 2'-O-acyl-ADP-ribose | - |
? | |
NAD+ + [BMAL1 protein]-N6-acyl-L-lysine | - |
Homo sapiens | nicotinamide + [BMAL1 protein]-L-lysine + 2'-O-acyl-ADP-ribose | - |
? |
Synonyms | Comment | Organism |
---|---|---|
SIRT1 | - |
Rattus norvegicus |
SIRT1 | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | dependent on | Rattus norvegicus | |
NAD+ | dependent on | Homo sapiens |