Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(7aS,12aS)-7-(4-chlorophenyl)-1,6,7,7a,12,12a-hexahydroindolo[3,2-c]pyrazolo[3,4-f]quinoline | about 5% inhibition at 0.05 mM | Rattus norvegicus | |
(7aS,12aS)-7-(4-methoxyphenyl)-1,6,7,7a,12,12a-hexahydroindolo[3,2-c]pyrazolo[3,4-f]quinoline | about 38% inhibition at 0.05 mM | Rattus norvegicus | |
(7aS,12aS)-7-phenyl-1,6,7,7a,12,12a-hexahydroindolo[3,2-c]pyrazolo[3,4-f]quinoline | about 18% inhibition at 0.05 mM | Rattus norvegicus | |
(7aS,12aS)-7-[4-(thiophen-2-yl)phenyl]-1,6,7,7a,12,12a-hexahydroindolo[3,2-c]pyrazolo[3,4-f]quinoline | about 16% inhibition at 0.05 mM | Rattus norvegicus | |
(7aS,12aS)-9-bromo-7-(4-chlorophenyl)-1,6,7,7a,12,12a-hexahydroindolo[3,2-c]pyrazolo[3,4-f]quinoline | about 50% inhibition at 0.05 mM | Rattus norvegicus | |
(7aS,12aS)-9-bromo-7-(4-fluorophenyl)-1,6,7,7a,12,12a-hexahydroindolo[3,2-c]pyrazolo[3,4-f]quinoline | about 65% inhibition at 0.05 mM | Rattus norvegicus | |
(7aS,12aS)-9-bromo-7-(4-methoxyphenyl)-1,6,7,7a,12,12a-hexahydroindolo[3,2-c]pyrazolo[3,4-f]quinoline | about 65% inhibition at 0.05 mM | Rattus norvegicus | |
(7aS,12aS)-9-bromo-7-phenyl-1,6,7,7a,12,12a-hexahydroindolo[3,2-c]pyrazolo[3,4-f]quinoline | about 70% inhibition at 0.05 mM | Rattus norvegicus | |
(7aS,12aS)-9-bromo-7-[4-(furan-2-yl)phenyl]-1,6,7,7a,12,12a-hexahydroindolo[3,2-c]pyrazolo[3,4-f]quinoline | about 78% inhibition at 0.05 mM | Rattus norvegicus | |
meta-azi-propofol | only binds specifically and competitively to the enzyme when co-equilibrated with other substrates | Homo sapiens | |
meta-azi-propofol | only binds specifically and competitively to the enzyme when co-equilibrated with other substrates | Rattus norvegicus | |
propofol | only binds specifically and competitively to the enzyme when co-equilibrated with other substrates | Homo sapiens | |
propofol | only binds specifically and competitively to the enzyme when co-equilibrated with other substrates | Rattus norvegicus |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
37000 | - |
x * 37000, SDS-PAGE | Rattus norvegicus |
37000 | - |
x * 37000, SDS-PAGE | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
NAD+ + [alpha-tubulin]-N6-acyl-L-lysine | Rattus norvegicus | - |
nicotinamide + [alpha-tubulin]-L-lysine + 2'-O-acyl-ADP-ribose | - |
? | |
NAD+ + [alpha-tubulin]-N6-acyl-L-lysine | Homo sapiens | - |
nicotinamide + [alpha-tubulin]-L-lysine + 2'-O-acyl-ADP-ribose | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q8IXJ6 | - |
- |
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
NAD+ + [alpha-tubulin]-N6-acyl-L-lysine | - |
Rattus norvegicus | nicotinamide + [alpha-tubulin]-L-lysine + 2'-O-acyl-ADP-ribose | - |
? | |
NAD+ + [alpha-tubulin]-N6-acyl-L-lysine | - |
Homo sapiens | nicotinamide + [alpha-tubulin]-L-lysine + 2'-O-acyl-ADP-ribose | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 37000, SDS-PAGE | Rattus norvegicus |
? | x * 37000, SDS-PAGE | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
SIRT2 | - |
Rattus norvegicus |
SIRT2 | - |
Homo sapiens |