Literature summary for 2.3.1.286 extracted from

Yamagata, K.; Goto, Y.; Nishimasu, H.; Morimoto, J.; Ishitani, R.; Dohmae, N.; Takeda, N.; Nagai, R.; Komuro, I.; Suga, H.; Nureki, O.
Structural basis for potent inhibition of SIRT2 deacetylase by a macrocyclic peptide inducing dynamic structural change (2014), Structure, 22, 345-352.

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Crystallization (Commentary)

Crystallization (Comment)	Organism
crystallization at 4°C by the sitting-drop vapor diffusion method. Crystal structure of human SIRT2 in complex with a macrocyclic peptide inhibitor S2iL5, at 2.5 A resolution	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
macrocyclic peptide inhibitor S2iL5	the inhibitor binds to the active site of SIRT2 through extensive interactions. The inhibitor induces an open-to-closed domain movement and a helix-to-coil transition in a SIRT2-specific region	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q8IXJ6	-	-

Purification (Commentary)

Purification (Comment)	Organism
-	Homo sapiens

Synonyms

Synonyms	Comment	Organism
SIRT2	-	Homo sapiens

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Release 2023.1 (January 2023)