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Literature summary for 2.3.1.286 extracted from

  • Fischer, F.; Gertz, M.; Suenkel, B.; Lakshminarasimhan, M.; Schutkowski, M.; Steegborn, C.
    Sirt5 deacylation activities show differential sensitivities to nicotinamide inhibition (2012), PLoS One, 7, e45098.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.3.1.286

Cloned(Commentary)

Cloned (Comment) Organism
-
 Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
nicotinamide 0.5 mM, complete inhibition Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9NTG7
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
NAD+ + TRSG(N6-acetyl)KVMR peptide based on an acetyl-CoA synthetase 2 acetylation site Homo sapiens nicotinamide + TRSGKVMR + 2'-O-acetyl-ADP-ribose
-
 ?

Synonyms

Synonyms Comment Organism
SIRT3
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.8
-
 assay at Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.043
-
 pH 7.8, 37°C, substrate: TRSG(N6-acetyl)KVMR Homo sapiens nicotinamide