Literature summary for 2.3.1.286 extracted from

Guan, X.; Lin, P.; Knoll, E.; Chakrabarti, R.
Mechanism of inhibition of the human sirtuin enzyme SIRT3 by nicotinamide: computational and experimental studies (2014), PLoS One, 15, e107729.

Search for more literature for 2.3.1.286

Inhibitors

Inhibitors	Comment	Organism	Structure
Isonicotinamide	weak competitive inhibitor of hSIRT3 with respect to NAD+ in vitro; weak inhibitor	Homo sapiens
nicotinamide	mixed noncompetitive inhibitor. Inhibition of SIRT3 involves apparent competition between the inhibitor and the enzyme cofactor NAD+; predominantly noncompetitive inhibitor	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q96EB6	-	-
Homo sapiens	Q9NTG7	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
NAD+ + TRSG(N6-acetyl)KVMRRLLR	acetylated substrate peptide based on the sequence of acetyl-coenzyme A synthetase 2	Homo sapiens	nicotinamide + TRSGKVMRRLLR + 2'-O-acetyl-ADP-ribose	-	?

Synonyms

Synonyms	Comment	Organism
SIRT1	-	Homo sapiens
SIRT3	-	Homo sapiens

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.0367	-	pH 8, 37°C	Homo sapiens	nicotinamide
0.0681	-	pH 8, 37°C	Homo sapiens	nicotinamide
12200	-	pH 8, 37°C, weak inhibitor	Homo sapiens	Isonicotinamide
13800	-	pH 8, 37°C, weak competitive inhibitor of hSIRT3 with respect to NAD+ in vitro	Homo sapiens	Isonicotinamide

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)