Literature summary for 2.3.1.286 extracted from

Zhao, X.; Allison, D.; Condon, B.; Zhang, F.; Gheyi, T.; Zhang, A.; Ashok, S.; Russell, M.; MacEwan, I.; Qian, Y.; Jamison, J.A.; Luz, J.G.
The 2.5 A crystal structure of the SIRT1 catalytic domain bound to nicotinamide adenine dinucleotide (NAD+) and an indole (EX527 analogue) reveals a novel mechanism of histone deacetylase inhibition (2013), J. Med. Chem., 56, 963-969.

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Cloned(Commentary)

Cloned (Comment)	Organism
a gene encoding the C-terminally His-tagged SIRT1 catalytic domain is expressed in SF9 cells	Homo sapiens

Crystallization (Commentary)

Crystallization (Comment)	Organism
hanging drop vapor diffusion using a 1:1 drop ratio. The 2.5 A crystal structure of the SIRT1 catalytic domain bound to NAD+ and 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide (EX527)	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide	-	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q96EB6	-	-

Purification (Commentary)

Purification (Comment)	Organism
-	Homo sapiens

Synonyms

Synonyms	Comment	Organism
SIRT1	-	Homo sapiens
sirtuin 1	-	Homo sapiens

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Release 2023.1 (January 2023)