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Literature summary for 2.3.1.286 extracted from

  • Ponugoti, B.; Kim, D.H.; Xiao, Z.; Smith, Z.; Miao, J.; Zang, M.; Wu, S.Y.; Chiang, C.M.; Veenstra, T.D.; Kemper, J.K.
    SIRT1 deacetylates and inhibits SREBP-1C activity in regulation of hepatic lipid metabolism (2010), J. Biol. Chem., 285, 33959-33970.
    View publication on PubMedView publication on EuropePMC
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
NAD+ + [SREBP-1c]-N6-acetyl-L-lysine Mus musculus SREBP-1c is a key lipogenic activator. Deacetylation of SREBP-1c by SIRT1 inhibits SREBP-1c activity by decreasing its stability and its association with its lipogenic target gene promoters nicotinamide + [SREBP-1c]-L-lysine + 2'-O-acetyl-ADP ribose
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Organism

Organism UniProt Comment Textmining
Mus musculus Q923E4
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
NAD+ + [SREBP-1c]-N6-acetyl-L-lysine SREBP-1c is a key lipogenic activator. Deacetylation of SREBP-1c by SIRT1 inhibits SREBP-1c activity by decreasing its stability and its association with its lipogenic target gene promoters Mus musculus nicotinamide + [SREBP-1c]-L-lysine + 2'-O-acetyl-ADP ribose
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NAD+ + [SREBP-1c]-N6-acetyl-L-lysine SREBP-1c is a key lipogenic activator Mus musculus nicotinamide + [SREBP-1c]-L-lysine + 2'-O-acetyl-ADP ribose
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 ?

Synonyms

Synonyms Comment Organism
SIRT1
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 Mus musculus