Literature summary for 2.3.1.286 extracted from

Jeong, J.; Juhn, K.; Lee, H.; Kim, S.H.; Min, B.H.; Lee, K.M.; Cho, M.H.; Park, G.H.; Lee, K.H.
SIRT1 promotes DNA repair activity and deacetylation of Ku70 (2007), Exp. Mol. Med., 39, 8-13.

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Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
NAD+ + [DNA repair factor Ku70]-N6-acetyl-L-lysine382	Homo sapiens	SIRT1 modulates DNA repair activity, which can be regulated by the acetylation status of repair protein Ku70 following DNA damage	nicotinamide + [DNA repair factor Ku70]-L-lysine382 + 2'-O-acetyl-ADP-ribose	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q96EB6	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
NAD+ + [DNA repair factor Ku70]-N6-acetyl-L-lysine382	-	Homo sapiens	nicotinamide + [DNA repair factor Ku70]-L-lysine382 + 2'-O-acetyl-ADP-ribose	-	?
NAD+ + [DNA repair factor Ku70]-N6-acetyl-L-lysine382	SIRT1 modulates DNA repair activity, which can be regulated by the acetylation status of repair protein Ku70 following DNA damage	Homo sapiens	nicotinamide + [DNA repair factor Ku70]-L-lysine382 + 2'-O-acetyl-ADP-ribose	-	?

Synonyms

Synonyms	Comment	Organism
SIRT1	-	Homo sapiens

General Information

General Information	Comment	Organism
metabolism	SIRT1 modulates DNA repair activity, which can be regulated by the acetylation status of repair protein Ku70 following DNA damage	Homo sapiens

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Release 2023.1 (January 2023)