Application | Comment | Organism |
---|---|---|
medicine | inhibitors of sirtuin-2 deacetylase are protective in various models of Huntingtons disease by decreasing polyglutamine aggregation, a hallmark of pathology of Huntingtons disease | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-(N-(4-chlorophenyl)-N-methylsulfamoyl)-N-(4-cyano-2-fluorophenyl)isonicotinamide | highly selective inhibitor for SIRT2, low inhibition of SIRT1 and SIRT3 | Homo sapiens | |
2-(N-(4-chlorophenyl)-N-methylsulfamoyl)-N-(4-cyanophenyl)isonicotinamide | selective inhibitor for SIRT2, low inhibition of SIRT1 and SIRT3 | Homo sapiens | |
3-(azepan-1-ylsulfonyl)-N-(3-nitrophenyl)benzamide | highly selective inhibitor for SIRT2, low inhibition of SIRT1 and SIRT3 | Homo sapiens | |
3-(N-(4-acetylphenyl)-N-methylsulfamoyl)-N-(4-chlorophenyl)benzamide | highly selective inhibitor for SIRT2, no inhibition of SIRT1, low inhibition of and SIRT3 | Homo sapiens | |
3-(N-(4-acetylphenyl)-N-methylsulfamoyl)-N-(4-cyanophenyl)benzamide | highly selective inhibitor for SIRT2, low inhibition of SIRT1 and SIRT3 | Homo sapiens | |
3-(N-(4-acetylphenyl)-N-methylsulfamoyl)-N-(5-chloropyridin-2-yl)benzamide | highly selective inhibitor for SIRT2, low inhibition of SIRT1, no inhibition of and SIRT3 | Homo sapiens | |
3-(N-(4-bromophenyl)-N-methylsulfamoyl)-N-(4-chloro-2-fluorophenyl)-N-methylbenzamide | highly selective inhibitor for SIRT2, low inhibition of SIRT1 and SIRT3 | Homo sapiens | |
3-(N-(4-chlorophenyl)-N-methylsulfamoyl)-N-(4-(methylsulfinyl)phenyl)benzamide | highly selective inhibitor for SIRT2, no inhibition of SIRT1, low inhibition of and SIRT3 | Homo sapiens | |
3-(N-(4-chlorophenyl)-N-methylsulfamoyl)-N-(4-(methylsulfonyl)phenyl)benzamide | highly selective inhibitor for SIRT2, low inhibition of SIRT1 and SIRT3 | Homo sapiens | |
3-(N-(4-chlorophenyl)-N-methylsulfamoyl)-N-(4-cyano-2-fluorophenyl)benzamide | highly selective inhibitor for SIRT2, low inhibition of SIRT1 and SIRT3 | Homo sapiens | |
3-(N-(4-chlorophenyl)-N-methylsulfamoyl)-N-(4-cyanophenyl)benzamide | highly selective inhibitor for SIRT2, low inhibition of SIRT1, no inhibition of and SIRT3 | Homo sapiens | |
3-(N-(4-chlorophenyl)-N-methylsulfamoyl)-N-(5-cyanopyridin-2-yl)benzamide | highly selective inhibitor for SIRT2, low inhibition of SIRT1, no inhibition of and SIRT3 | Homo sapiens | |
3-(N-(4-chlorophenyl)-N-methylsulfamoyl)-N-(5-fluoropyridin-2-yl)benzamide | highly selective inhibitor for SIRT2, no inhibition of SIRT1 and SIRT3 | Homo sapiens | |
3-(N-(4-chlorophenyl)-N-methylsulfamoyl)-N-(6-chloropyridazin-3-yl)benzamide | highly selective inhibitor for SIRT2, low inhibition of SIRT1 | Homo sapiens | |
3-(N-(5-chloropyridin-2-yl)-N-methylsulfamoyl)-N-(4-cyanophenyl)benzamide | highly selective inhibitor for SIRT2, low inhibition of SIRT1 and SIRT3 | Homo sapiens | |
4-bromo-N-(3-(N-methyl-N-(4-(methylsulfonyl)phenyl)sulfamoyl)phenyl)benzamide | selective inhibitor for SIRT2, low inhibition of SIRT1 and SIRT3 | Homo sapiens | |
N-(3-(N-(4-chlorophenyl)-N-methylsulfamoyl)phenyl)-4-cyanobenzamide | highly selective inhibitor for SIRT2, low inhibition of SIRT1, no inhibition of and SIRT3 | Homo sapiens | |
N-(4-acetylphenyl)-3-(N-(4-acetylphenyl)-N-methylsulfamoyl)benzamide | highly selective inhibitor for SIRT2, no inhibition of SIRT1 and SIRT3 | Homo sapiens | |
N-(4-bromo-2-fluorophenyl)-3-(N-(4-bromophenyl)-N-methylsulfamoyl)-N-methylbenzamide | highly selective inhibitor for SIRT2, no inhibition of SIRT1 and SIRT3 | Homo sapiens | |
N-(4-chlorophenyl)-3-(N-methyl-N-(4-(methylsulfonyl)phenyl)sulfamoyl)benzamide | highly selective inhibitor for SIRT2, no inhibition of SIRT1 and SIRT3 | Homo sapiens | |
N-(4-cyanophenyl)-3-(N-(4-(1-hydroxyethyl)phenyl)-N-methylsulfamoyl)benzamide | - |
Homo sapiens | |
N-(4-cyanophenyl)-3-(N-(4-fluorophenyl)-N-methylsulfamoyl)benzamide | highly selective inhibitor for SIRT2, low inhibition of SIRT1 and SIRT3 | Homo sapiens | |
N-(4-cyanophenyl)-3-(N-(4-methoxyphenyl)-N-methylsulfamoyl)benzamide | highly selective inhibitor for SIRT2, low inhibition of SIRT1 and SIRT3 | Homo sapiens | |
N-(4-cyanophenyl)-3-(N-methyl-N-(4-(methylsulfonyl)phenyl)sulfamoyl)benzamide | highly selective inhibitor for SIRT2, low inhibition of SIRT1, no inhibition of and SIRT3 | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q8IXJ6 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
NAD+ + [alpha-tubulin]-N6-acetyl-L-lysine40 | - |
Homo sapiens | nicotinamide + [alpha-tubulin]-L-lysine40 + 2'-O-acetyl-ADP ribose | - |
? |
Synonyms | Comment | Organism |
---|---|---|
SIRT2 | - |
Homo sapiens |
sirtuin-2 deacetylase | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0038 | - |
pH and temperature not specified in the publication | Homo sapiens | N-(3-(N-(4-chlorophenyl)-N-methylsulfamoyl)phenyl)-4-cyanobenzamide | |
0.0049 | - |
pH and temperature not specified in the publication | Homo sapiens | 2-(N-(4-chlorophenyl)-N-methylsulfamoyl)-N-(4-cyanophenyl)isonicotinamide | |
0.0061 | - |
pH and temperature not specified in the publication | Homo sapiens | 3-(N-(4-chlorophenyl)-N-methylsulfamoyl)-N-(4-cyanophenyl)benzamide | |
0.0061 | - |
pH and temperature not specified in the publication | Homo sapiens | 3-(N-(5-chloropyridin-2-yl)-N-methylsulfamoyl)-N-(4-cyanophenyl)benzamide | |
0.0063 | - |
pH and temperature not specified in the publication | Homo sapiens | 4-bromo-N-(3-(N-methyl-N-(4-(methylsulfonyl)phenyl)sulfamoyl)phenyl)benzamide | |
0.0066 | - |
pH and temperature not specified in the publication | Homo sapiens | 3-(N-(4-chlorophenyl)-N-methylsulfamoyl)-N-(4-cyano-2-fluorophenyl)benzamide | |
0.0068 | - |
pH and temperature not specified in the publication | Homo sapiens | 3-(N-(4-acetylphenyl)-N-methylsulfamoyl)-N-(4-chlorophenyl)benzamide | |
0.0069 | - |
pH and temperature not specified in the publication | Homo sapiens | N-(4-bromo-2-fluorophenyl)-3-(N-(4-bromophenyl)-N-methylsulfamoyl)-N-methylbenzamide | |
0.0073 | - |
pH and temperature not specified in the publication | Homo sapiens | 3-(N-(4-acetylphenyl)-N-methylsulfamoyl)-N-(4-cyanophenyl)benzamide | |
0.0075 | - |
pH and temperature not specified in the publication | Homo sapiens | 3-(N-(4-bromophenyl)-N-methylsulfamoyl)-N-(4-chloro-2-fluorophenyl)-N-methylbenzamide | |
0.0091 | - |
pH and temperature not specified in the publication | Homo sapiens | 3-(N-(4-chlorophenyl)-N-methylsulfamoyl)-N-(5-fluoropyridin-2-yl)benzamide | |
0.0094 | - |
pH and temperature not specified in the publication | Homo sapiens | N-(4-cyanophenyl)-3-(N-(4-fluorophenyl)-N-methylsulfamoyl)benzamide | |
0.0095 | - |
pH and temperature not specified in the publication | Homo sapiens | 3-(N-(4-chlorophenyl)-N-methylsulfamoyl)-N-(4-(methylsulfinyl)phenyl)benzamide | |
0.0095 | - |
pH and temperature not specified in the publication | Homo sapiens | N-(4-cyanophenyl)-3-(N-methyl-N-(4-(methylsulfonyl)phenyl)sulfamoyl)benzamide | |
0.0096 | - |
pH and temperature not specified in the publication | Homo sapiens | N-(4-cyanophenyl)-3-(N-(4-methoxyphenyl)-N-methylsulfamoyl)benzamide | |
0.0098 | - |
pH and temperature not specified in the publication | Homo sapiens | 3-(N-(4-chlorophenyl)-N-methylsulfamoyl)-N-(4-(methylsulfonyl)phenyl)benzamide | |
0.0102 | - |
pH and temperature not specified in the publication | Homo sapiens | 2-(N-(4-chlorophenyl)-N-methylsulfamoyl)-N-(4-cyano-2-fluorophenyl)isonicotinamide | |
0.0108 | - |
pH and temperature not specified in the publication | Homo sapiens | 3-(azepan-1-ylsulfonyl)-N-(3-nitrophenyl)benzamide | |
0.0115 | - |
pH and temperature not specified in the publication | Homo sapiens | N-(4-cyanophenyl)-3-(N-(4-(1-hydroxyethyl)phenyl)-N-methylsulfamoyl)benzamide | |
0.0132 | - |
pH and temperature not specified in the publication | Homo sapiens | 3-(N-(4-acetylphenyl)-N-methylsulfamoyl)-N-(5-chloropyridin-2-yl)benzamide | |
0.0156 | - |
pH and temperature not specified in the publication | Homo sapiens | 3-(N-(4-chlorophenyl)-N-methylsulfamoyl)-N-(6-chloropyridazin-3-yl)benzamide | |
0.0159 | - |
pH and temperature not specified in the publication | Homo sapiens | N-(4-chlorophenyl)-3-(N-methyl-N-(4-(methylsulfonyl)phenyl)sulfamoyl)benzamide | |
0.0189 | - |
pH and temperature not specified in the publication | Homo sapiens | N-(4-acetylphenyl)-3-(N-(4-acetylphenyl)-N-methylsulfamoyl)benzamide | |
0.0199 | - |
pH and temperature not specified in the publication | Homo sapiens | 3-(N-(4-chlorophenyl)-N-methylsulfamoyl)-N-(5-cyanopyridin-2-yl)benzamide |